Gitakan teghekagirPub Date : 2023-06-19DOI: 10.46991/pysu:b/2023.57.2.100
Ani S. Dadayan, Artavazd S. Poghosyan, Samvel G. Ghazaryan, Anahit M. Hovhannisyan, Melanya S. Ghazaryan, Slavik A. Dadayan
{"title":"COMPARATIVE STUDY OF THE CONTENT OF ANTHOCYANINS IN THE FRUITS OF BLUEBERRIES, BLACKBERRIES AND BLACKCURRANTS. DEVELOPMENT OF A TECHNOLOGICAL METHOD FOR OBTAINING PARTIALLY PURIFIED NEW-GALENIC EXTRACTS","authors":"Ani S. Dadayan, Artavazd S. Poghosyan, Samvel G. Ghazaryan, Anahit M. Hovhannisyan, Melanya S. Ghazaryan, Slavik A. Dadayan","doi":"10.46991/pysu:b/2023.57.2.100","DOIUrl":"https://doi.org/10.46991/pysu:b/2023.57.2.100","url":null,"abstract":"The work is devoted to a comparative study of the content of anthocyanins in the fruits of blueberries, blackberries and blackcurrants to develop a technological method for producing partially purified extracts. The latter, due to the significant content of anthocyanins, compounds with antioxidant, antiaggregate, angioprotective, anti-inflammatory activities stipulate their use in the complex therapy of ophthalmic diseases (myopia, age-related macular degeneration, diabetic retinopathy). The objects of the study were fresh natural fruits of common blueberries (Vaccinium myrtillus L.), blackberries (Rubus caesius L.) and blackcurrants (Ribes nigrum L.) collected in the foothill landscapes of the city of Aparan of the Republic of Armenia, harvested in 2022. The purpose of this study was to determine the comparative indicators of the quality and content of anthocyanins in fresh fruit extracts by direct spectrometry and obtain environmentally friendly extracts with the lowest content of macro- (Fe, Cu, Zn, Ca, Mg, etc.) and microelements (Mn, Co, Cd, V, Se, Cr, As, Pb, etc.) by ion-exchange sorption and desorption. It has been shown that the highest content of the total amount of anthocyanins in terms of cyanidin-3-O-glycoside is determined in the juice of fresh blueberries in an acidic medium at an analytical wavelength of 546 nm – 4.21 ± 0.18%. At the same time, the completeness of extraction of anthocyanins (≥ 95%) from blueberries is achieved at a ratio of raw material to extractant (95% EtOH, 1% HCl) 1 : 50 and when heated in a boiling water bath for 40 min. It has been shown that the content of these macro- and microelements in the extracts after ion-exchange sorption and desorption with Ku-2×8 (H+) cation exchanger does not exceed the permissible limits.","PeriodicalId":475666,"journal":{"name":"Gitakan teghekagir","volume":"71 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135421245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gitakan teghekagirPub Date : 2023-05-31DOI: 10.46991/pysu:b/2023.57.2.077
Ameer Khalid Jamal, Ali Qutaiba Mohammed, Abdulrahman Hameed Rasheed, Ahmed Raheem Al-Rubbawi, Gohar A. Shahinyan
{"title":"HERBAL INFUSIONS AS INHIBITORS OF TRYPSIN ACTIVITY IN WATER AND POLAR ORGANIC SOLVENT–WATER SYSTEMS","authors":"Ameer Khalid Jamal, Ali Qutaiba Mohammed, Abdulrahman Hameed Rasheed, Ahmed Raheem Al-Rubbawi, Gohar A. Shahinyan","doi":"10.46991/pysu:b/2023.57.2.077","DOIUrl":"https://doi.org/10.46991/pysu:b/2023.57.2.077","url":null,"abstract":"The inhibition of digestive enzyme trypsin by polyphenolic compounds derived from mountainous herbal infusions, as well as the effect of polarity and acidity of the media on this process were studied by virtue of UV-Vis absorption spectroscopy at 293.15 K. Mountainous herbal infusions (thyme, peppermint) are well known due to their biomedical significance and wide use as a beverage. The binding constant (Kb) and standard Gibbs energy change (ΔG0) were calculated. The obtained results show that polyphenols extracted from herbal infusions significantly inhibit trypsin. Moreover, the effect of thyme infusion is stronger compared with that of peppermint. The results show that the change of both polarity and H-bonding ability of polar organic cosolvent significantly alters the value of Kb, indicating that H-bonds and electrostatic interactions are the main driving forces in these interactions.","PeriodicalId":475666,"journal":{"name":"Gitakan teghekagir","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135438663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gitakan teghekagirPub Date : 2023-05-03DOI: 10.46991/pysu:b/2023.57.2.068
Tariel V. Ghochikyan, Armen S. Galstyan, Melanya A. Samvelyan
{"title":"A NEW METHOD FOR THE PREPARATION OF HYDRAZIDES OF SUBSTITUTED GAMMA-HYDROXYBUTANOIC ACIDS","authors":"Tariel V. Ghochikyan, Armen S. Galstyan, Melanya A. Samvelyan","doi":"10.46991/pysu:b/2023.57.2.068","DOIUrl":"https://doi.org/10.46991/pysu:b/2023.57.2.068","url":null,"abstract":"A method providing a high yield (80–94%) for producing gamma-hydroxy-butanoic acids hydrazides by the interaction of various representatives of cyclic esters with 85% hydrazine hydrate has been elaborated. It has been established that the introduction of a gamma-hydroxypropyl residue into the hydrazides composition results in new biological properties.","PeriodicalId":475666,"journal":{"name":"Gitakan teghekagir","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135111055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}