{"title":"Ethanopharmacological Approach to Control the Replication of 2019-nCov in Host- An Insilico Study","authors":"None M.Thenmozhi, Suma Mohan, M.Sathish Kumar, None S.T.Kumaravel","doi":"10.37155/2972-449x-vol1(2)-72","DOIUrl":"https://doi.org/10.37155/2972-449x-vol1(2)-72","url":null,"abstract":"2019- nCoV viral disease threatening every individual throughout the world. It is a highly challenging task to control the spread everywhere. There are certain antiviral drugs, steroids that are currently being prescribed to infected patients for faster recovery. But there is no proper cure today for this pandemic. In this present study, we have focused on controlling the replication and other possibilities of interaction of the 2019-nCoV virus inside the host cells. There are various herbs prescribed to us to improve our immunity and prepare our bodies to fight against this pathogen. In this study, herb compounds that are selected are Andrographolide (AP1), 14-deoxy-11,12-didehydroandrographolide(AP3), Ascorbic acid, Cinnamaldehyde, Curcumin, Diallyl sulfide, Eugenol. Gingerol, Kaempferol, Deacetylnimbin, Piperine, Quercetin, thymol, thymoquinone, Vasicine based on the literature survey. Selected ligands are most of them to treat respiratory tract infections and are also related to improving humoral immunity. Selected Ligand was allowed to dock against viral proteins which Crystal Structure of the SARS COV-2 Papain-like protease (Figure 1a) (PDB ID: 6wx4), RNA dependent RNA polymerase (Figure 1b) (PDB ID: 7c2k), Crystal structure of SARS COV-2 ORF7A encoded accessory protein (Figure 1c) (PDB ID: 6w37) Crystal structure of SARS COV-2 ADP-Ribose phosphatase NSP3 Proteins (PDB ID: 6w6y), PDB ID 6zsl Crystal structure of SARS COV-2 helicase NSP13 (PDB ID: 6ZSL), Crystal structure of NSP10-NSP16 Complex (PDB ID: 7bq7), PDB ID 6xdc Crystal structure of SARS COV-2 ORF3a Protein (PDB ID: 6xdc) to study their efficacy to control the replication and possible interactions in the human system using computational docking study. A Protein-Protein interaction study was also performed to study the efficacy of papain enzyme inhibitory efficacy of selected target proteins. Molecular dynamics studies were also performed to ensure the ligand efficacy for the selected target proteins.","PeriodicalId":474241,"journal":{"name":"BME Horizon","volume":"70 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135151420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BME HorizonPub Date : 2023-01-01DOI: 10.37155/2972-449x-vol1(2)-69
Thenmozhi M, Manimegalai V, Joy Glory C
{"title":"Green Synthesis of Copper Oxid Nanoparticles Using Allmania nodiflora Leaf Extract and Its Characterization","authors":"Thenmozhi M, Manimegalai V, Joy Glory C","doi":"10.37155/2972-449x-vol1(2)-69","DOIUrl":"https://doi.org/10.37155/2972-449x-vol1(2)-69","url":null,"abstract":"Nanoparticles are unique in nature and have a large surface area; these are the reasons for choosing nanoparticles in various medical as well as industrial purposes. Copper oxide nanoparticles were synthesised from the leaves of Allmania nodiflora to study the dye degradation ability since dye degradation has become a difficult task in recent days. Synthesised copper oxide nanoparticles were characterised using X-ray diffraction (XRD), Scanning Electron Microscopy (SEM), and Fourier Transform Infrared Spectroscopy (FT-IR). The photocatalytic activities of the synthesised nanoparticles were analysed using UV-Visible spectroscopy. All the characterization methods ensured the prepared copper oxide particles were nanoparticles. There were no studies performed in synthesizing copper oxide nanoparticles using Allmania nodiflora. In addition to the analysis synthesized copper oxide nanoparticles purity also ensured using EDX results using Energy Dispersive X-ray analysis.","PeriodicalId":474241,"journal":{"name":"BME Horizon","volume":"153 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135157595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}