SVOA Microbiology最新文献

{"title":"Phytochemistry and Bioactivities of Duguetia furfuracea (A.St.-Hil.) Saff.","authors":"Fábio Caboclo Moreira, Ademar Maia Filho, Emílio Sousa Albuquerque, Francisca de Fátima Silva de Sousa, Dieferson Leandro de Souza, Marcos Aurélio Figueirêdo dos Santos, Jeovane Henrique de Souza, Camila Fonseca Bezerra, Bruno Melo de Alcântara, Mikael A. de Souza, C. S. Leandro, Ana Letícia Gonçalves Pereira, José Aglailson Oliveira da Anunciação, Maria Eliana Vieira Figueroa, P. Fernandes, Alessandro Martins Ribeiro, Bernardo Hamuyela Luciano, José Weverton Almeida-Bezerra","doi":"10.58624/svoamb.2024.05.043","DOIUrl":"https://doi.org/10.58624/svoamb.2024.05.043","url":null,"abstract":"Duguetia furfuracea, belonging to the Annonaceae family, is a perennial plant found in the Central-West, Southeast, and Northeast regions of Brazil, known for its various uses in traditional medicine. Used as a hypocholesterolemic, anorexigenic, and for treating various conditions including cancer and infections, its medicinal properties have garnered scientific interest. Studies have identified several bioactive compounds in different parts of the plant. The leaves contain phenolic acids, flavonoids, and alkaloids such as duguetine and dicentrinone, which exhibit antioxidant, anti-inflammatory, and antimicrobial properties. Phytochemical analysis revealed the presence of rare sesquiterpenes such as α-santalene and (-)-ishwarane, strengthening the chemotaxonomic relationship between Annonaceae and Aristolochiaceae. The species has shown larvicidal activity against Aedes aegypti, pediculicidal activity against Pediculus capitis, and antiplasmodial activity against Trypanosoma cruzi. Additionally, it possesses anti-inflammatory, antinociceptive, and cytotoxic activities, being effective against Candida spp. strains and cancer cells. However, its toxicity was observed in studies with Drosophila melanogaster and cellular models, indicating the need for further studies to ensure its safe use. The plant shows potential for therapeutic applications due to its chemical diversity, but it is essential to deepen investigations into its mechanisms of action and develop extraction and isolation methods to maximize its medicinal potential safely and effectively. Continued research is crucial to integrate D. furfuracea into modern phytotherapy and the development of new drugs. The presence of these bioactive compounds highlights the importance of exploring the full pharmacological potential of D. furfuracea for future therapeutic advancements, emphasizing its promising role in natural medicine. the pharmacological properties of D. furfuracea underscore its potential for innovative drug development and traditional medicinal enhancement.","PeriodicalId":474111,"journal":{"name":"SVOA Microbiology","volume":"20 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141646228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibacterial Evaluation in vitro of the Essential Oil of Astronium urundeuva (M.Allemão) Engl. Against Multidrug-Resistant Strains","authors":"Terezinha Raila Ramos de Sousa, José Thyálisson da Costa Silva, Ismael Almeida da Costa, T. F. Moura, João Arthur de Oliveira Borges, S. Menezes, Alef Martins de Oliveira, Viviane Bezerra da Silva, Ana Letícia Gonçalves Pereira, Cícero Jorge Verçosa, Mikael A. de Souza, Priscilla Augusta de Sousa Fernandes, José Aglailson Oliveira da Anunciação, R. P. da Cruz, M. Morais-Braga, Henrique Douglas Melo Coutinho, J. Almeida-Bezerra","doi":"10.58624/svoamb.2024.05.038","DOIUrl":"https://doi.org/10.58624/svoamb.2024.05.038","url":null,"abstract":"Given the current disastrous situation of bacterial resistance resulting in deaths worldwide due to the misuse of antibiotics, it is necessary to explore natural means that can reverse this situation. Thus, the essential oil of Astronium urundeuva, which possesses properties directly related to its antibacterial effects, was the focus of this research. The objective was to analyze the antibacterial activity of the essential oil from A. urundeuva leaves, as well as its antibiotic-enhancing action. Initially, approval was obtained from the Biodiversity Authorization and Information Systems (SISBio) and the National System for Management of Genetic Heritage and Associated Traditional Knowledge (SisGen). Subsequently, collections were made, and extracts from A. urundeuva leaves were obtained. In addition, in vitro tests were conducted to determine the minimum inhibitory concentration (MIC) of the essential oil, along with tests to identify any modifying activity on antibiotic action. Bacterial strains such as Pseudomonas aeruginosa, Escherichia coli, and Staphylococcus aureus were used for these tests. It was found through the minimum inhibitory concentration that the essential oil (EO) alone could not prevent bacterial growth, considering that its result was > 512 µg/mL. However, it was observed that the essential oil, in conjunction with certain antibiotics, had a potentiating effect on its antibacterial action. The most significant enhancers were Norfloxacin, as it achieved higher action against all three tested strains when combined with the EO, and Gentamicin, which, when combined with the EO, strengthened its action against E. coli and S. aureus. However, Ampicillin, when combined with the EO, showed significance only against S. aureus. Therefore, this study revealed that the essential oil of A. urundeuva may be promising, as it can enhance the action of antibiotics against bacterial growth.","PeriodicalId":474111,"journal":{"name":"SVOA Microbiology","volume":"11 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140435663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Challenges and Opportunities in Biofertilizer Commercialization","authors":"Anurag Yadav, K. Yadav","doi":"10.58624/svoamb.2024.05.037","DOIUrl":"https://doi.org/10.58624/svoamb.2024.05.037","url":null,"abstract":"As eco-friendly alternative to chemical fertilizers, biofertilizers have gained significance in the quest for sustainable farming. While challenges exist, such as regulatory hurdles and technical complexities, the opportunities in this field are substantial. Understanding rhizosphere engineering can enhance biofertilizers' efficiency, ensuring they provide maximum crop benefits. Genetic engineering of bioinoculants offers a pathway to tailor biofertilizers to specific crop needs, potentially increasing their effectiveness. Multi-trait, multi-strain, and multi-nutrient microbial formulations have the potential to revolutionize the biofertilizer market, allowing for customized solutions that address a range of agricultural needs. These innovations are complemented by market dynamics and the integration of nanotechnology, which can further enhance biofertilizer performance and reach. Such opportunities indicate a bright future for biofertilizer commercialization, where sustainable agriculture can benefit from advanced formulations with an improved understanding of soil-plant interactions. Biofertilizers' prospects are promising, offering a more sustainable and environmentally friendly approach to nourishing the world's growing population.","PeriodicalId":474111,"journal":{"name":"SVOA Microbiology","volume":"29 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140514888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pulmonary Tuberculosis Prevalence and Associated Factors Among Adult Patients Visiting Finchwa Health Center, West Guji Zone, Southern Ethiopia","authors":"Alqeer Aliyo, Yonas Abdisa, Gumi Robale, Dagnamyelew Tilahun, Lidya Aman, Abdullah Ibrahim","doi":"10.58624/svoamb.2023.04.034","DOIUrl":"https://doi.org/10.58624/svoamb.2023.04.034","url":null,"abstract":"Background: Mycobacterium tuberculosis is the name of the microorganism that causes tuberculosis. The bacteria typically affect the lungs, but if not adequately treated, it can affect any part of the body, such as the kidney, spine, and brain. In Ethiopia, tuberculosis is a significant public health issue. However, no epidemiological research in the study area has been recorded. Objective: The study was undertaken to assess the prevalence of pulmonary tuberculosis and associated risk factors PTB presumptive patients who visited the Finchawa Health Center from November 2022 to February 2023. Methods: A cross-sectional study was conducted among 273 study participants. Structured questionnaire was used to gather sociodemographic and risk factor information. Sputum samples were taken from the study participants and analyzed under a microscope. Data were analyzed by using SPSS Version-25 software. Binary logistic regression analysis adjusted odds ratio (AOR) with respective 95% confidence interval (CI) and the threshold for statistical significance was set at p 0.05. Result: The prevalence of smear-positive Tb among presumptive patients was 4.8% with 95% CI (2.24–7.29). Prevalence of PTB with HIV co-infections, and PTB with diabetes mellitus (DM) comorbidity were 38.5%, and 27.3%, respectively. In comparison to their counterparts, having a family size greater than five (AOR = 5.15, 95% CI. = 1.46- 18.29), having a history of family contact (AOR = 6.7, 95% CI. = 1.78-22.99) and having a history of Tb infection (AOR = 4.76, 95% CI. I = 1.05-21.62) were all found to be predictors for developing smear-positive pulmonary tuberculosis. Conclusion: The prevalence of smear-positive pulmonary tuberculosis in the Finchawa health center was found to be high. Therefore, zonal and town health departments should emphasize detailed tracing of presumptive, regular assessment of PTB suspects and refer to public health care institutions for early diagnosis and initiation of anti-TB treatment.","PeriodicalId":474111,"journal":{"name":"SVOA Microbiology","volume":" 40","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135292383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of EIs in Vapour Phase Hydrogen Peroxide Decontamination Cycle Optimisation and Rapid Validation","authors":"Callum Dew","doi":"10.58624/svoamb.2023.04.033","DOIUrl":"https://doi.org/10.58624/svoamb.2023.04.033","url":null,"abstract":"AstraZeneca investigated the use of Enzymatic Indicators (EIs) in order to optimise their Sterility Testing Isolator gassing cycles. The quantitative nature of the EI data has enabled identification and successful validation of an optimised cycle, which has halved the original gassing cycle, leading to reduced costs, reduced periods of Isolator downtime and increased overall productivity. When completing the validation, the EI data was also used to provide greater confidence in the instance of erroneous Biological Indicator results, and as such has also expedited validation of a new ‘wet’ vaporised H2O2 generator. In addition, the EI data provided increased data across the sterility isolator chamber, allowing for confidence that sufficient cycle decontamination is achieved in all challenge locations, and as such there is no risk of BI failures upon requalification. EIs are therefore regarded as a beneficial companion for BI data when looking to optimise productivity of current isolators, and when used for validation of new equipment.","PeriodicalId":474111,"journal":{"name":"SVOA Microbiology","volume":"20 4","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135430456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peritonitis Due to Haemophilus Influenzae in Peritoneal Dialysis: Report of An Exceptional Case","authors":"William Montenegro Gutiérrez, Lina Alejandra Beltrán Mogollón, Sharom Barbosa Velázquez, Laura Carolina Neira R, Carlos Armando Nuñez Leal, Miguel Alejandro Suárez Amaya, Julio César Moreno-Alfonso","doi":"10.58624/svoamb.2023.04.032","DOIUrl":"https://doi.org/10.58624/svoamb.2023.04.032","url":null,"abstract":"Case Description: 33-year-old woman with a history of end-stage renal disease on peritoneal dialysis, who came to the emergency department for abdominal pain of sudden onset associated with a change in the color of the peritoneal fluid. Clinical Findings: The patient had signs of systemic inflammatory response and generalized abdominal pain, with marked leukocyte response in peritoneal fluid cytochemistry. Treatment and Outcome: Empirical antibiotic treatment was started targeting the most prevalent microorganisms in abdominal infections associated with peritoneal dialysis, however with poor response to it and subsequent isolation of Haemophilus Influenzae for which antibiotherapy was modified with subsequent progressive clearance of peritoneal fluid and resolution of symptoms. Clinical Relevance: We describe the case of a patient on peritoneal dialysis who presented a bacterial peritonitis caused by H. Influenzae, an extremely infrequent germ in this type of infections. Although the presence of this germ is exceptional in peritoneal dialysis catheter-associated peritonitis, this microorganism should be ruled out in a patient with catheter-associated peritonitis that does not respond to the usual antibiotic therapy. To our knowledge only 8 cases have been reported in the literature and none in our setting.","PeriodicalId":474111,"journal":{"name":"SVOA Microbiology","volume":"76 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135724139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Giardiasis in the Southwest Region of the United States: Causes and Preventive Measures","authors":"Jeriah Boyd, Shazia Tabassum Hakim","doi":"10.58624/svoamb.2023.04.031","DOIUrl":"https://doi.org/10.58624/svoamb.2023.04.031","url":null,"abstract":"Giardia is a protozoan parasite of the small intestine, and a leading cause of diarrheal diseases worldwide in a variety of animals, as well as humans. Despite the decrease, Giardiasis remains the most commonly reported intestinal parasitic infection principally in the Southwestern region of the United States. The parasite is typically transmitted by fecal-oral route and may be transmitted by direct intake or indirectly from contaminated food or water. Symptomatic Giardiasis is often treated to reduce the duration of symptoms, to prevent future complications, and to minimize transmission of the parasite to other hosts. The clinical image of Giardiasis is mixed, with high variability in severity of clinical disease which can become chronic or be followed by post-infectious sequelae. At present, treatment options include nitroimidazoles derivatives; especially metronidazole, which has been the mainstay of treatment for decades and is still widely used. The Navajo Nation located in the Southwestern region of the United States has suffered from the scarcity of water expediting Navajo populations to use water resources such as underground water, river streams, lakes and surface water as their main source of accessibility. The lack of adequate domestic and municipal water has led several Navajo families to become ill with waterborne infectious diseases like Giardiasis. More recently, molecular methods have become amateur in diagnosis for testing patient samples as well as water samples for Giardiasis. Through direct immunofluorescent staining and other methods that detect intact organisms have improved the detection of Giardia trophozoites or cysts. An understanding of clinical and molecular variability of organisms is important for effective treatment and the response of remedies that are commonly used. The molecular classification of bacteria and viruses isolated from Indigenous patients might have their own specification that can be correlated with isolates from water samples collected from the same localities. This correlation could help us in source tracking and finding solutions for the communities who are already at risk due to the lack of infrastructure and resources. In this review of literature, the causes and preventive measures of Giardiasis are covered to potentially help understand the importance behind this parasitic disease, more specifically on the Navajo Nation of the Southwest of the US.","PeriodicalId":474111,"journal":{"name":"SVOA Microbiology","volume":"86 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136236324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}