International journal of medical, pharmacy and drug research最新文献

A brief overview of the ethnomedical, pharmacological, and phytochemical uses of Sida spinosa 简要概述了藜麦的民族医学、药理学和植物化学用途

International journal of medical, pharmacy and drug research Pub Date : 2023-01-01 DOI: 10.22161/ijmpd.7.5.3

Deepak Sharma, Richa Mishra, Manmeet Singh Saluja

引用次数: 0

Synthesis & Pharmacological Activity of Cytotoxicity Assay of Coumarins SVCM1-SVCM7 合成,香豆素SVCM1-SVCM7细胞毒性测定的药理活性

International journal of medical, pharmacy and drug research Pub Date : 2023-01-01 DOI: 10.22161/ijmpd.7.5.1

Swapnil Verma, Priya Jain

引用次数: 0

Effect of Poly Herbal Extract of Curcuma Amada Rhizome and Sida Spinosa Leaves on STZ-Induced Tissue Damage Marker Enzymes 姜黄根茎和芦笋叶提取物对stz诱导的组织损伤标记酶的影响

International journal of medical, pharmacy and drug research Pub Date : 2023-01-01 DOI: 10.22161/ijmpd.7.4.7

C Manikandhan, Vivek Daniel, Kratika Daniel

{"title":"Effect of Poly Herbal Extract of Curcuma Amada Rhizome and Sida Spinosa Leaves on STZ-Induced Tissue Damage Marker Enzymes","authors":"C Manikandhan, Vivek Daniel, Kratika Daniel","doi":"10.22161/ijmpd.7.4.7","DOIUrl":"https://doi.org/10.22161/ijmpd.7.4.7","url":null,"abstract":"Diabetes mellitus (DM) remains a global health challenge with rising prevalence and associated complications. Among its various forms, Type 2 Diabetes (T2DM) poses a significant health concern. Chronic hyperglycemia in T2DM leads to oxidative stress, which, in turn, contributes to tissue damage and dysfunction. The present study investigates the potential therapeutic impact of a poly-herbal extract comprising Curcuma amada rhizome and Sida spinosa leaves on tissue damage marker enzymes in a Streptozotocin (STZ)-induced diabetic animal model. Curcuma amada, known as mango ginger, and Sida spinosa have long been acknowledged for their medicinal properties, often attributed to their rich content of bioactive compounds such as curcuminoids and flavonoids. These compounds possess antioxidant and anti-inflammatory properties, making them promising candidates for mitigating oxidative stress-induced tissue damage. In this research, an animal model for T2DM was induced using STZ, followed by the administration of the poly-herbal extract. Blood glucose levels were monitored throughout the study, and various tissue samples, including liver and kidney, were analyzed to assess the activity levels of tissue damage marker enzymes such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), serum creatinine, and blood urea nitrogen (BUN). The findings of this study aim to shed light on the potential protective effects of the poly-herbal extract against STZ-induced tissue damage marker enzyme alterations. A thorough examination of these effects will offer insights into the therapeutic potential of herbal remedies in mitigating complications associated with T2DM. This research adds to the growing body of knowledge on complementary treatments for diabetes, bringing us one step closer to a more comprehensive understanding of the therapeutic potential of natural compounds in managing this widespread and challenging condition.","PeriodicalId":470178,"journal":{"name":"International journal of medical, pharmacy and drug research","volume":"55 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135496833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Formulation and Evaluation of Floating in Situ Gel of Lafutidine 拉弗丁原位漂浮凝胶的制备及评价

International journal of medical, pharmacy and drug research Pub Date : 2023-01-01 DOI: 10.22161/ijmpd.7.5.2

Vijay Kumar Damodhar

{"title":"Formulation and Evaluation of Floating in Situ Gel of Lafutidine","authors":"Vijay Kumar Damodhar","doi":"10.22161/ijmpd.7.5.2","DOIUrl":"https://doi.org/10.22161/ijmpd.7.5.2","url":null,"abstract":"Gastroesophageal reflux disease (GERD) and peptic ulcers are prevalent gastrointestinal disorders that significantly impact the quality of life of affected individuals. Lafutidine, a histamine H2-receptor antagonist, has demonstrated effectiveness in managing these conditions. However, its short gastric residence time limits its therapeutic efficacy. To address this limitation, we aimed to formulate and evaluate a floating in situ gel of Lafutidine for prolonged gastric retention and enhanced therapeutic outcomes. In vivo studies were conducted on albino Wistar rats to assess the pharmacokinetic parameters and gastric residence time. The pharmacokinetic evaluation demonstrated that the floating in situ gel exhibited improved Lafutidine bioavailability compared to the conventional dosage form. Gastric residence time was significantly extended, enhancing Lafutidine's therapeutic efficacy. Overall, the formulation and evaluation of the floating in situ gel of Lafutidine demonstrated its potential as an effective drug delivery system for the management of GERD and peptic ulcers. The extended gastric retention and enhanced bioavailability of Lafutidine make this formulation a promising option for improving patient compliance and therapeutic outcomes in the treatment of these gastrointestinal disorders. Further clinical studies are warranted to establish its clinical efficacy and safety profile.","PeriodicalId":470178,"journal":{"name":"International journal of medical, pharmacy and drug research","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136307196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0