Frontiers in Clinical Neurology and Neurosurgery最新文献

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Cerebral blood flow-single-photon emission computed tomography and Brodmann mapping may facilitate the evaluation of clinical features of early-onset Alzheimer’s disease 脑血流-单光子发射计算机断层扫描和Brodmann成像可能有助于评估早发性阿尔茨海默病的临床特征

Frontiers in Clinical Neurology and Neurosurgery Pub Date : 2022-09-29 DOI: 10.36879/fcnn.2022.000101

{"title":"Cerebral blood flow-single-photon emission computed tomography and Brodmann mapping may facilitate the evaluation of clinical features of early-onset Alzheimer’s disease","authors":"","doi":"10.36879/fcnn.2022.000101","DOIUrl":"https://doi.org/10.36879/fcnn.2022.000101","url":null,"abstract":"A relatively large numbers of studies have reported on the clinical features, classifications, and impairment of cerebral blood flow (CBF) in\u0000cases with Alzheimer’s disease. However, only few reports have investigated the relationships between clinical tests and lesion areas in the\u0000brain with significantly reduced CBF, assessed using single-photon emission computed tomography (SPECT).\u0000This study aimed to assess the correlations between impaired Mini-Mental State Examination (MMSE) scores and reduced CBF using\u0000Brodmann area mapping and classify early-onset Alzheimer’s disease (EOAD). Thirty-one patients aged <65 years, with memory\u0000impairment, were examined using CBF-SPECT, and MMSE during the same period. Twenty patients were diagnosed with EOAD.\u0000We divided the patients into two groups: one with bilateral reduction of CBF in temporo-parietal region and the other with unilateral\u0000reduction. The bilateral group had significantly lower MMSE scores than the unilateral reduction group, but it had significantly less family\u0000history, significantly poor prognoses, and ten significantly reduced CBF in the Brodmann area (BA) with SPECT. In the bilateral group,\u0000there were large correlations between impaired MMSE and reduced CBF regions in the BA. These findings confirm that the classification\u0000of EOAD may pave the way to understand patients with EOAD.","PeriodicalId":448658,"journal":{"name":"Frontiers in Clinical Neurology and Neurosurgery","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123972307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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