发布求助
文献互助 智能选刊 最新文献

Archives of Diabetes and Endocrine System最新文献

筛选
英文 中文
Hypoglycemic Drugs and Advanced Glycation Endproducts 降糖药物和晚期糖基化终产物
Archives of Diabetes and Endocrine System Pub Date : 2019-04-15 DOI: 10.20431/2455-5983.0501002
W. Xiong, Zhiqiang Zhou, Xian-Dang Zhang
{"title":"Hypoglycemic Drugs and Advanced Glycation Endproducts","authors":"W. Xiong, Zhiqiang Zhou, Xian-Dang Zhang","doi":"10.20431/2455-5983.0501002","DOIUrl":"https://doi.org/10.20431/2455-5983.0501002","url":null,"abstract":"Recent data showed that 9.1% of adults worldwide have diabetes, and 318 million adults have a high risk of developing diabetes in the future. Diabetes and its complications have serious impact on human health. In the early stages of diabetes, excessive advanced glycation endproducts (AGEs) accumulate in the body and bind to its receptor RAGE, which impairs glucose regulation. In the later stages of diabetes, increased blood glucose can accelerate the production of more AGEs. AGEs play a pivotal role in the development of diabetes and its complications. In recent years, AGEs have become one of the research hotspots. The search for potential drug targets that can block or reduce the accumulation of AGEs has attracted increasing attention. This review summarizes the role of AGEs and the effects of various hypoglycemic agents on AGEs from the perspective of mechanisms, in order to provide reference for the further search for targeted drugs against AGEs.","PeriodicalId":447189,"journal":{"name":"Archives of Diabetes and Endocrine System","volume":"57 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127582021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of Combination Therapy with SGLT2 Inhibitor with Metformin as Initial Treatment for Type2 Diabetes-Advantages of Oral Fixed Drug Pill Like Empagliflozin/Metformin in Patients with Cardiovascular and Renal Risk-A Short Communication SGLT2抑制剂联合二甲双胍作为2型糖尿病初始治疗的作用——口服固定药物如恩格列清/二甲双胍在心血管和肾脏风险患者中的优势——简短交流
Archives of Diabetes and Endocrine System Pub Date : 1900-01-01 DOI: 10.22259/2638-4981.0201002
Dr. Kulvinder Kochar Kaur, Dr. Gautam Allahbadia, Dr. Mandeep Singh
{"title":"Role of Combination Therapy with SGLT2 Inhibitor with Metformin as Initial Treatment for Type2 Diabetes-Advantages of Oral Fixed Drug Pill Like Empagliflozin/Metformin in Patients with Cardiovascular and Renal Risk-A Short Communication","authors":"Dr. Kulvinder Kochar Kaur, Dr. Gautam Allahbadia, Dr. Mandeep Singh","doi":"10.22259/2638-4981.0201002","DOIUrl":"https://doi.org/10.22259/2638-4981.0201002","url":null,"abstract":"","PeriodicalId":447189,"journal":{"name":"Archives of Diabetes and Endocrine System","volume":"592 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116317818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
A Preliminary Study of Low-Dose Angiotensin 1-7 Plus the Pineal Hormone Melatonin in the Treatment of Human Systemic Diseases other than Cancer and Autoimmune Pathologies 低剂量血管紧张素1-7联合松果体褪黑素治疗除癌症和自身免疫性病变外的全身疾病的初步研究
Archives of Diabetes and Endocrine System Pub Date : 1900-01-01 DOI: 10.22259/2638-4981.0401001
P. Lissoni, E. Porta, F. Rovelli, G. Messina, A. Lissoni, G. Porro, Davide Porro
{"title":"A Preliminary Study of Low-Dose Angiotensin 1-7 Plus the Pineal Hormone Melatonin in the Treatment of Human Systemic Diseases other than Cancer and Autoimmune Pathologies","authors":"P. Lissoni, E. Porta, F. Rovelli, G. Messina, A. Lissoni, G. Porro, Davide Porro","doi":"10.22259/2638-4981.0401001","DOIUrl":"https://doi.org/10.22259/2638-4981.0401001","url":null,"abstract":"","PeriodicalId":447189,"journal":{"name":"Archives of Diabetes and Endocrine System","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133524913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sarcopenic Obesity-A Minireview-Does it Lead to a Greater Incident of Type 2 Diabetes, Metabolic Syndrome or Mortality than When Sarcopenia or Obesity Exist Separately 肌少症型肥胖-一项小型综述-是否比肌少症或肥胖单独存在时导致更大的2型糖尿病，代谢综合征或死亡率
Archives of Diabetes and Endocrine System Pub Date : 1900-01-01 DOI: 10.22259/2638-4981.0201005
Dr. Kulvinder Kochar Kaur, Dr. Gautam Allahbadia, Dr. Mandeep Singh
{"title":"Sarcopenic Obesity-A Minireview-Does it Lead to a Greater Incident of Type 2 Diabetes, Metabolic Syndrome or Mortality than When Sarcopenia or Obesity Exist Separately","authors":"Dr. Kulvinder Kochar Kaur, Dr. Gautam Allahbadia, Dr. Mandeep Singh","doi":"10.22259/2638-4981.0201005","DOIUrl":"https://doi.org/10.22259/2638-4981.0201005","url":null,"abstract":"","PeriodicalId":447189,"journal":{"name":"Archives of Diabetes and Endocrine System","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127012020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Drug Interactions of SGLT2 Inhibitors (Gliflozins) Involving UGT Enzymes SGLT2抑制剂(格列净)与UGT酶的药物相互作用
Archives of Diabetes and Endocrine System Pub Date : 1900-01-01 DOI: 10.22259/2638-4981.0202003
Dr. Naina Mohamed Pakkir Maideen
{"title":"Drug Interactions of SGLT2 Inhibitors (Gliflozins) Involving UGT Enzymes","authors":"Dr. Naina Mohamed Pakkir Maideen","doi":"10.22259/2638-4981.0202003","DOIUrl":"https://doi.org/10.22259/2638-4981.0202003","url":null,"abstract":"Sodium glucose cotransporter 2 (SGLT2) inhibitors are antidiabetic drugs which are useful in the management of blood sugar of patients with type 2 diabetes, along with diet and exercise. The SGLT2 inhibitors are the substrates of UGT enzymes and SGLT2 inhibitorss uch as Dapagliflozin, Canagliflozin and Ipragliflozin are metabolised by glucuronidation predominantly by UGT1A9 enzyme. In addition, Canagliflozin and Ipragliflozin are also metabolised by UGT2B4. The drugs inhibiting or inducing UGT1A9 and other UGT enzymes are expected to alter the pharmacokinetics of SGLT2 inhibitors. Although the plasma exposure of Dapagliflozin and Canagliflozin are increased slightly by the concomitant use of Mefenamic acid and Probenecid respectively, these interactions were not considered clinically meaningful. Rifampicin and other UGT inducers such as Phenytoin, Phenobarbital and Ritonavir were observed to decrease the plasma levels of Canagliflozin, insignificantly. Based on the results of this review, SGLT2 inhibitors could be coadministered with any medicines without dosage adjustments except Canagliflozin, which needs higher dosage while using along with UGT enzyme inducers.","PeriodicalId":447189,"journal":{"name":"Archives of Diabetes and Endocrine System","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128453569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
An Assessment of Source and Dose-Dependent Diabetes ameliorating Activity of ethanolic Extract of Nigella Sativa on Alloxan-Induced Diabetic Rat Model 黑草乙醇提取物对四氧嘧啶诱导的糖尿病大鼠模型的源性和剂量依赖性改善作用的评价
Archives of Diabetes and Endocrine System Pub Date : 1900-01-01 DOI: 10.36648/2572-5432.21.6.42
D. Akter, ni Akter Rokeya, Md. Rafat Tahsin, E. Haque, A. Sultana, Shaila Kabir, A. Choudhury, J. A. Chowdhury, Md. Shah Amran
{"title":"An Assessment of Source and Dose-Dependent Diabetes ameliorating Activity of ethanolic Extract of Nigella Sativa on Alloxan-Induced Diabetic Rat Model","authors":"D. Akter, ni Akter Rokeya, Md. Rafat Tahsin, E. Haque, A. Sultana, Shaila Kabir, A. Choudhury, J. A. Chowdhury, Md. Shah Amran","doi":"10.36648/2572-5432.21.6.42","DOIUrl":"https://doi.org/10.36648/2572-5432.21.6.42","url":null,"abstract":"Metabolic disorder diabetes results from an alteration of the secretion or action \u0000 of insulin. Nigella sativa is a traditionally used specimen since ancient times. We \u0000 aimed to investigate the hypoglycemic potential of ethanolic extract of Nigella \u0000 sativa seed powder solution both in a dose and source-dependent manner as well \u0000 as to fathom out its safety profile so that this plant can be used to ameliorate \u0000 diabetes. Diabetes was induced in the rat model via intraperitoneal injection of \u0000 alloxan (150 mg/kg). Ethanolic extract of T. Nigella sativa was administered to rats’ \u0000 belonged to different groups. Blood glucose levels were assessed periodically and \u0000 the safety profiles were evaluated through assessment of SGOT, SGPT, creatinine, \u0000 and lipid profiles after sacrificing the animals. It has been evidenced that Nigella \u0000 sativa possesses anti-diabetic activity. Furthermore, the extract is capable of \u0000 reversing the disturbed pathological state towards a healthy status. Besides, \u0000 these therapeutic consequences possess dose-dependent potentiality (p>0.05), \u0000 further a noteworthy source dependent (p> 0.01) response were experienced. It \u0000 may confer that the inconsistency associated with the remedial impacts between \u0000 2 same doses belonged to two distinct sources are due to accuracy of lab-based \u0000 preparation, geographic area of cultivation, and also the season of collection. \u0000 Apart from that, the visual and statistical inspections have evidence that the \u0000 medium and the high dose are imparting almost indistinguishable therapeutic \u0000 effects. Presumably, the reason lies beneath the receptor saturation issue.","PeriodicalId":447189,"journal":{"name":"Archives of Diabetes and Endocrine System","volume":"123 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122631294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Factors Responsible for Non-Communicable Diseases Except Diabetes among Bangladeshi Adults 导致孟加拉国成年人非传染性疾病(糖尿病除外)的因素
Archives of Diabetes and Endocrine System Pub Date : 1900-01-01 DOI: 10.22259/2638-4981.0202005
K. Bhuyan
{"title":"Factors Responsible for Non-Communicable Diseases Except Diabetes among Bangladeshi Adults","authors":"K. Bhuyan","doi":"10.22259/2638-4981.0202005","DOIUrl":"https://doi.org/10.22259/2638-4981.0202005","url":null,"abstract":"","PeriodicalId":447189,"journal":{"name":"Archives of Diabetes and Endocrine System","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128577607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Canonical Correlation Analysis to Study the Impacts of Different Social Factors on Level of BMI and Prevalence of Diabetes Among Children and Adolescents of Some Affluent Families 典型相关分析研究不同社会因素对部分富裕家庭儿童青少年BMI水平及糖尿病患病率的影响
Archives of Diabetes and Endocrine System Pub Date : 1900-01-01 DOI: 10.22259/2638-4981.0201001
K. Bhuyan, A. F. Urmi
{"title":"Canonical Correlation Analysis to Study the Impacts of Different Social Factors on Level of BMI and Prevalence of Diabetes Among Children and Adolescents of Some Affluent Families","authors":"K. Bhuyan, A. F. Urmi","doi":"10.22259/2638-4981.0201001","DOIUrl":"https://doi.org/10.22259/2638-4981.0201001","url":null,"abstract":"","PeriodicalId":447189,"journal":{"name":"Archives of Diabetes and Endocrine System","volume":"51 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131840011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
SNX3, UBE2O and SNX27 Protein Expressions are Altered in the Hypothalamus of High-Fat Diet Fed Mice. Possible Implications for Retrograde Protein Trafficking 高脂饮食小鼠下丘脑SNX3、ube20和SNX27蛋白表达发生改变。逆行蛋白质运输的可能含义
Archives of Diabetes and Endocrine System Pub Date : 1900-01-01 DOI: 10.22259/2638-4981.0202001
L. R. de Oliveira, Nathalia Augusta de Oliveira Gomes, L. Ferreira, M. L. de Freitas, A. M. Fernandes, Célio José de Castro Júnior, F. Jehee, A. Bosco, K. Fernandes
{"title":"SNX3, UBE2O and SNX27 Protein Expressions are Altered in the Hypothalamus of High-Fat Diet Fed Mice. Possible Implications for Retrograde Protein Trafficking","authors":"L. R. de Oliveira, Nathalia Augusta de Oliveira Gomes, L. Ferreira, M. L. de Freitas, A. M. Fernandes, Célio José de Castro Júnior, F. Jehee, A. Bosco, K. Fernandes","doi":"10.22259/2638-4981.0202001","DOIUrl":"https://doi.org/10.22259/2638-4981.0202001","url":null,"abstract":"Obesity is a worldwide health problem characterized by overeating and satiety regulation breakdown. Arcuate nucleus (ARC) in the hypothalamus and controls energy homeostasis mainly through leptin binding to its receptors (ObR). Defective central response to leptin in obesity also involves impairment of endosomal ObR recycling, degradation, and trafficking, which compromises receptor steady state in the plasma membrane. Here we report that ARC from high-fat diet (HFD) mice presented alterations in the expression of proteins involved in endosomal retrograde transport. Indeed, we observed a significant decrease of SNX3 and UBE2O levels as analyzed by confocal microscopy, suggesting an impairment of the endosomal retrograde routein the ARC of HFD fed mice when compared to controls. On the other hand, the fast recycling protein marker, the SNX27, was upregulated in the ARC of HFD fed mice, suggesting that some kind of compensation is happening.","PeriodicalId":447189,"journal":{"name":"Archives of Diabetes and Endocrine System","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132722124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：604180095
Book学术官方微信