Statistics and Applications最新文献

筛选
英文 中文
Identification of Geographic Specific SARS-Cov-2 Mutations by Random Forest Classification and Variable Selection Methods. 随机森林分类和变量选择方法鉴定地理特异性SARS-Cov-2突变
IF 0.4
Statistics and Applications Pub Date : 2020-07-01 Epub Date: 2020-06-30
Manoj Kandpal, Ramana V Davuluri
{"title":"Identification of Geographic Specific SARS-Cov-2 Mutations by Random Forest Classification and Variable Selection Methods.","authors":"Manoj Kandpal,&nbsp;Ramana V Davuluri","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>RNA viral genomes have very high mutations rates. As infection spreads in the host populations, different viral lineages emerge acquiring independent mutations that can lead to varied infection and death rates in different parts of the world. By application of Random Forest classification and feature selection methods, we developed an analysis pipeline for identification of geographic specific mutations and classification of different viral lineages, focusing on the missense-variants that alter the function of the encoded proteins. We applied the pipeline on publicly available SARS-CoV-2 datasets and demonstrated that the analysis pipeline accurately identified country or region-specific viral lineages and specific mutations that discriminate different lineages. The results presented here can help designing country-specific diagnostic strategies and prioritizing the mutations for functional interpretation and experimental validations.</p>","PeriodicalId":44466,"journal":{"name":"Statistics and Applications","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7514111/pdf/nihms-1620642.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38527629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信