Herbal Formula Science最新文献

筛选

英文中文

Acute toxicity, Dermal and Ocular Irritation Studies of Taglisodog-eum ointment 塔利索夫软膏的急性毒性、皮肤和眼部刺激研究

Herbal Formula Science Pub Date : 2016-11-30 DOI: 10.14374/HFS.2016.24.4.289

Jung Bok Lee, Jae-Hwan Choi, Hee Taek Kim, Yun-Kyung Kim, Young-beob Yu

{"title":"Acute toxicity, Dermal and Ocular Irritation Studies of Taglisodog-eum ointment","authors":"Jung Bok Lee, Jae-Hwan Choi, Hee Taek Kim, Yun-Kyung Kim, Young-beob Yu","doi":"10.14374/HFS.2016.24.4.289","DOIUrl":"https://doi.org/10.14374/HFS.2016.24.4.289","url":null,"abstract":"Objectives TSE ointment(2,000mg/kg), body weight, mortality, and clinical signs of the rats were observed for 14days. Primary skin irritation and ocular irritation tests for TSE ointment were performed in male New Zealand White Rabbits. In dermal and ocular irritation test, body weight, mortality, clinical signs, Primary Irritation Index(P.I.I.), and The Index of Acute Ocular Irritaion(I.A.O.I.) of rabbit were observed after applying at abraded skin and eye balls with Taglisodog-eum ointment. Results : In the results of acute skin toxicity, no significant differences were found in body weight, the clinical sign and the mortality between control and TSE ointment treated group. In primary dermal irritation test, body weight, the clinical sign and the mortality were not significantly changed and Primary Irritation Index(P.I.I.) was 0.8, indicating TSE ointment as weak irritant material. In ocular irritation test, The Index of Acute Ocular Irritaion was 0.0, indicating TSE ointment as non-irritating to the eye of the rabbits. To evaluate toxicity of the TSE ointment in animal test, body weight, the clinical signs, the skin and eye irritation check were conducted; TSE ointment was considered to be weak dermal irritant in test animals. The no response of eye irritation test was observed in this experimental condition. Conclusions : According to the above toxicity test, We consider that this results is helpful for saying about the safety of TSE ointment in clinical use.","PeriodicalId":440301,"journal":{"name":"Herbal Formula Science","volume":"42 6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127988889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1