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Current Protein & Peptide Science最新文献

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An Overview of the Deubiquitinase USP53: A Promising Diagnostic Marker and Therapeutic Target 去泛素化酶 USP53 综述：一种前景看好的诊断标志物和治疗靶标
Current Protein & Peptide Science Pub Date : 2024-06-03 DOI: 10.2174/0113892037292440240518194922
Guangce Xia, Yulin Guo, Jiajia Zhang, Meng Han, Xiangchao Meng, Ji Lv
{"title":"An Overview of the Deubiquitinase USP53: A Promising Diagnostic Marker and Therapeutic Target","authors":"Guangce Xia, Yulin Guo, Jiajia Zhang, Meng Han, Xiangchao Meng, Ji Lv","doi":"10.2174/0113892037292440240518194922","DOIUrl":"https://doi.org/10.2174/0113892037292440240518194922","url":null,"abstract":"\u0000\u0000Ubiquitination and deubiquitination are important mechanisms to maintain normal physiological\u0000activities, and their disorders or imbalances can lead to various diseases. As a subgroup of\u0000deubiquitinases (DUBs), the ubiquitin-specific peptidase (USP) family is closely related to many\u0000biological processes. USP53, one of the family members, is widely expressed in human tissues and\u0000participates in a variety of life activities, such as cell apoptosis, nerve transmission, and bone remodeling.\u0000Mutations in the USP53 gene can cause cholestasis and deafness and may also be a potential\u0000cause of schizophrenia. Knockout of USP53 can alleviate neuropathic pain induced by\u0000chronic constriction injury. Loss of USP53 up-regulates RANKL expression, promotes the cytogenesis\u0000and functional activity of osteoclasts, and triggers osteodestructive diseases. USP53 plays a\u0000tumor-suppressive role in lung cancer, renal clear cell carcinoma, colorectal cancer, liver cancer,\u0000and esophageal cancer but reduces the radiosensitivity of cervical cancer and esophageal cancer to\u0000induce radioresistance. Through the in-depth combination of literature and bioinformatics, this review\u0000suggested that USP53 may be a good potential biomarker or therapeutic target for diseases.\u0000","PeriodicalId":438625,"journal":{"name":"Current Protein & Peptide Science","volume":"101 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141389133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enzymatic Targets in the Anticancer Drug Discovery 抗癌药物发现中的酶靶点
Current Protein & Peptide Science Pub Date : 2024-01-01 DOI: 10.2174/138920372501240109145132
L. Scotti, M. Scotti
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引用次数: 0
Tribute to Prof. Ben M. Dunn: A Remarkable Biochemist andEditor-in-Chief of Current Protein & Peptide Science andProtein & Peptide Letters 向 Ben M. Dunn 教授致敬：杰出的生物化学家、《当前蛋白质与多肽科学》和《蛋白质与多肽通讯》主编
Current Protein &amp; Peptide Science Pub Date : 2024-01-01 DOI: 10.2174/138920372501240109105124
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引用次数: 0
Neurotoxic Aβ: Linking Extracellular and Intracellular Aβ in Alzheimer’s Disease 神经毒性Aβ:连接阿尔茨海默病的细胞外和细胞内Aβ
Current Protein &amp; Peptide Science Pub Date : 2021-06-01 DOI: 10.2174/13892037mtezwntch4
Uddin, MS
{"title":"Neurotoxic Aβ: Linking Extracellular and Intracellular Aβ in Alzheimer’s Disease","authors":"Uddin, MS","doi":"10.2174/13892037mtezwntch4","DOIUrl":"https://doi.org/10.2174/13892037mtezwntch4","url":null,"abstract":"","PeriodicalId":438625,"journal":{"name":"Current Protein &amp; Peptide Science","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121840882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Drug Repurposing Approaches: Existing Leads for Novel Threats and Drug Targets 药物再利用方法:新威胁和药物靶标的现有线索
Current Protein &amp; Peptide Science Pub Date : 2021-03-01 DOI: 10.2174/13892037mtewhmtit0
Usha, T
{"title":"Drug Repurposing Approaches: Existing Leads for Novel Threats and Drug Targets","authors":"Usha, T","doi":"10.2174/13892037mtewhmtit0","DOIUrl":"https://doi.org/10.2174/13892037mtewhmtit0","url":null,"abstract":"","PeriodicalId":438625,"journal":{"name":"Current Protein &amp; Peptide Science","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125032697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Mass Spectrometric (MS) Analysis of Proteins and Peptides 蛋白质和多肽的质谱分析
Current Protein &amp; Peptide Science Pub Date : 2021-02-01 DOI: 10.2174/13892037mta4xndyf4
Jayathirtha, M
{"title":"Mass Spectrometric (MS) Analysis of Proteins and Peptides","authors":"Jayathirtha, M","doi":"10.2174/13892037mta4xndyf4","DOIUrl":"https://doi.org/10.2174/13892037mta4xndyf4","url":null,"abstract":"","PeriodicalId":438625,"journal":{"name":"Current Protein &amp; Peptide Science","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134280939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recent Advances in Therapeutic Peptides for Breast Cancer Treatment 乳腺癌治疗肽的研究进展
Current Protein &amp; Peptide Science Pub Date : 2021-01-01 DOI: 10.2174/13892037mtexcnjacw
Beheshtirouy, S
{"title":"Recent Advances in Therapeutic Peptides for Breast Cancer Treatment","authors":"Beheshtirouy, S","doi":"10.2174/13892037mtexcnjacw","DOIUrl":"https://doi.org/10.2174/13892037mtexcnjacw","url":null,"abstract":"","PeriodicalId":438625,"journal":{"name":"Current Protein &amp; Peptide Science","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129646374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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