Volume 2 Issue 4 2021最新文献

{"title":"Cardiovascular risk among people of all ages during the recovery period after COVID-19 (1-3 months) in the background of morbid obesity of the first stage","authors":"O. Korkushko, V. Chyzhova, V. Shatilo, I. Samots, T. Kovtonyuk, A. Gavalko","doi":"10.47855/jal9020-2021-4-3","DOIUrl":"https://doi.org/10.47855/jal9020-2021-4-3","url":null,"abstract":"The aim of our study is to determine the correlation between obesity and overweight with COVID-19 among people aged over 40 years, in the period from 1 to 3 months after COVID-19 disease. Materials and methods: the group of subjects after COVID-19 consisted of 10 people, including 5 people at the age 40-59 years and 5 people at the age 60 years and older. The control group consisted of 21 individuals without COVID-19 and had a negative PCR test at the time of the survey: 5 individuals aged 40-59 years and 16 individuals aged 60 years and older. The subjects in both groups had cardiovascular risk factors and signs of metabolic syndrome. The subjects have been measured body weight (in kg), height (in cm), body mass index (BMI, in kg / m2), waist circumference (WC, in cm), hip circumference (HC, in cm) with the calculation of the ratio between WC and HC. For the assessment of the state of lipid metabolism, the levels of total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C) and low - density lipoprotein cholesterol (LDL-C), triglycerides (TG) in serum venous blood were determined by standard biochemical methods with the help of automatic biochemical analyzer \"Autolab\" by \"Boehringer Mannheim\" using the reagents from company \"BIO SYSTEMS\" (Spain). Cardiovascular risk indicators were calculated - Castelli index (TC/ HDL-C) and Boizel index (TG to HDL-C), and an updated SCORE-2 scale was used. The composition of the physique was determined using the device \"OMRON\". To exclude organic cardiac pathology, arrhythmias, and conduction, a standard ECG recording on a Ucard 200 device (Ukraine) was used. The microcirculation of the bulbar conjunctiva (slit lamp, \"Zeiss\", Germany) has been studied. Statistical data processing was performed using the program Statistica 10.0 (USA). \u0000Results: in the subjects included in the study, the indicators of general blood tests, which could indicate the presence of inflammation, were without any pathological changes. In accordance with the results of standard ECG, the subjects had no organic cardiac pathology, arrhythmia, and conduction. Younger patients with metabolic syndrome (MS) after COVID-19 had a statistically significantly higher BMI compared with the subgroup without COVID-19. Within each age group, the subjects of both subgroups (excluding COVID-19 and after COVID-19) have had general and visceral obesity rates that were combined with the other markers of metabolic syndrome, including dyslipidemia. It is shown that the calendar age of the patients with overweight after COVID-19 is statistically significantly higher than the calendar age of the patients with the overweight without COVID-19 in the anamnesis. The calendar age of the patients with the obesity of the 1-st grade after COVID-19 was significantly lower than the age of the patients without COVID-19. The indicator of very high cardiovascular risk is determined among the individuals of the senior age group, especially after COVID-19. Patients w","PeriodicalId":438366,"journal":{"name":"Volume 2 Issue 4 2021","volume":"66 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121495031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coronavirus disease 2019: neurological aspects. \u0000Review and own research","authors":"V. Bezrukov, V. Kuznetsov","doi":"10.47855/jal9020-2021-4-2","DOIUrl":"https://doi.org/10.47855/jal9020-2021-4-2","url":null,"abstract":"The main neurological consequences of COVID-19 (depression, psycho-emotional disturbances, strokes, neurodegenerative disorders and others); major ways of coronavirus penetration into the nervous system as well as mechanisms of development of some neurological complications of COVID-19 are presented in the article. The preliminary results of the analysis of changes in the functional state of the central nervous system of 36 patients with dyscirculatory encephalopathy of atherosclerotic and hypertensive genesis of the 1-2 stages before and 3-4 months after COVID-19 have been presented. It was found that in patients who have had COVID-19, there were headaches, sleep disorders, general weakness, memory impairment, muscle and limbs pains. Reorganization of bioelectrical activity of the brain also appeared. The general structure of the EEG was characterized by an increased power in the range of slow rhythms against a background of decreasing power in the range of cortical rhythms. A tendency to a decrease of cerebral blood flow in the separate vessels of carotid and vertebrobasilar basins, as well as expressed suppression of the vascular endothelial function were also found. It is evident from the results of this study that inclusion of the drugs possessing a multimodal vasoactive and metabolic action is necessary.\u0000\u0000Key words: coronavirus disease 2019, neurological complications, bioelectrical activity of the brain, cerebral blood flow, endothelial function.","PeriodicalId":438366,"journal":{"name":"Volume 2 Issue 4 2021","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128284194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prospects of successful treatment of Parkinson's disease \u0000using apomorphine","authors":"I. Karaban, N. Karasevych, T. Hasiuk","doi":"10.47855/jal9020-2021-4-1","DOIUrl":"https://doi.org/10.47855/jal9020-2021-4-1","url":null,"abstract":"Abstract. Optimising the treatment of idiopathic Parkinson's disease is a complex, multifaceted and continuous process that directly affects quality of life. The main position of this examination is the need for individualised therapy that provides optimal motor function with the least negative consequences. Apomorphine, a dopamine agonist used as rescue therapy for patients with motor fluctuations with a potentially positive effect on non-motor symptoms, is the only antiparkinsonian drug whose ability to control motor symptoms is equivalent to that of levodopa. Subcutaneous injection is the most effective and affordable way to correct dopaminergic insufficiency in Parkinson's disease. The data of multi-centre studies presented in the review confirm the high efficiency, adequate tolerability, and prospects of using apomorphine in the complex pathogenetic therapy of the disease. This review provides historical background and summarises the structure, mechanism of action, pharmacodynamics, indications, contraindications, and side effects of subcutaneous apomorphine injections in the advanced stages of Parkinson's disease.\u0000Keywords: Parkinson's disease; apomorphine; pharmacokinetics; mechanism of action; clinical trials; indications: and contraindications","PeriodicalId":438366,"journal":{"name":"Volume 2 Issue 4 2021","volume":"241 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132279699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}