{"title":"Introductory Chapter: Pertussis - Disease, Control and Challenges","authors":"W. Dias","doi":"10.5772/INTECHOPEN.77134","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.77134","url":null,"abstract":"","PeriodicalId":436958,"journal":{"name":"Pertussis - Disease, Control and Challenges","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124272113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Update on Epidemiology, Diagnosis, and Treatment of Pertussis","authors":"D. Hozbor","doi":"10.5772/INTECHOPEN.72847","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.72847","url":null,"abstract":"","PeriodicalId":436958,"journal":{"name":"Pertussis - Disease, Control and Challenges","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126777336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Preventive and Protective Properties of Pertussis Vaccines: Current Situation and Future Challenges","authors":"Detsch Sg, Provance Dw, Rocha da Silva F","doi":"10.5772/INTECHOPEN.75055","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.75055","url":null,"abstract":"Pertussis, more commonly known as whooping cough, is a potentially fatal respiratory disease caused by Bordetella pertussis . Two different types of vaccines provide effective protection: killed whole-cell vaccines (wPV) and more recently available acellular vaccines (aPVs) formulated with specific components. Disturbingly, while the vaccines are widely used, the incidence of disease is increasing in several developed countries that have switched from wPV to an aPV. It is suggested that the single most important underlying cause suggested for the resurgence is transmission through asymptomatic infections. While both vaccines protect against disease, a newly developed baboon model has shown that they do not prevent infection. Importantly, wPV-vaccinated animals appeared to clear an infection more rapidly than those vaccinated with aPV, which can relate to the period of possible disease transmission. To ultimately control whooping cough, it is clear that a more effective vaccine is needed that can prevent both disease and transmission. Modifications underway include the elimination of LPS from wPVs to improve their safety profiles and augmentation of aPVs with other bacterium proteins to increase immunoge-nicity and the longevity of protection. In the interim, vaccinations with aPV during pregnancy appear to protect newborns, the most susceptible to deadly pertussis.","PeriodicalId":436958,"journal":{"name":"Pertussis - Disease, Control and Challenges","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114726673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Clinical Experiences in Pertussis in a Population with High Vaccination Rate","authors":"F. M. Gomes, M. Valente, A. M. Escobar, S. Grisi","doi":"10.5772/INTECHOPEN.75684","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.75684","url":null,"abstract":"Infection caused by Bordetella pertussis in young infants can lead to severe illness and death. Several countries with good pertussis vaccine coverage, above 90%, had outbreaks of this disease from 2010, including Brazil. One of the strategies to reduce the transmission of pertussis to young infants, especially below 6 months of age, is the introduction of Tdap vaccination in pregnant women between 27 and 36 weeks of gestation. Vaccination of pregnant women with Tdap is an emergency measure to reduce hospitalizations and deaths from pertussis in young infants, especially those younger than 3 months of age, which is the population group where the most frequent serious illness occurs. Passive immunity to pertussis in these newborns is temporary, lasting less than 6 months, and there is discussion in the literature of its interference with maternal immunity and immu- nity of young infants to other vaccines. The acquired immunity to pertussis, both by natural disease and by vaccines, is temporary, and it is known that the immune response to the acellular vaccine is smaller and less durable than the whole-cell vaccine. New strategies for pertussis control should be developed to better cope with this disease overall. the true of in in for the best vaccine strategies to control the and its","PeriodicalId":436958,"journal":{"name":"Pertussis - Disease, Control and Challenges","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114198766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Pertussis Immunization in Pregnancy: A Review","authors":"G. Gabutti, A. Stefanati, Parvané Kuhdari","doi":"10.5772/INTECHOPEN.72085","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.72085","url":null,"abstract":"The pregnant woman has an altered immune response and, for some pathologies, is at increased risk of infection and of developing complications and serious outcomes. In addition, maternal infections can result in congenital anomalies, malformations or severe neonatal diseases. Vaccination of pregnant women can therefore have a double goal: to protect the mother from diseases that could have an impact on her health and to avoid infection/disease transmission to the fetus or the newborn. Despite the potential benefits of immunization in pregnant women, it is still evident reluctance and/or refusal of vaccinations by health professionals as well as by pregnant women, who are wary of the real advantages linked to vaccines. Concerning pertussis, immunization is strongly recommended in pregnancy and some data are already available in Europe as well as in other parts of the world. This review describes the rationale for this immunization and summarizes available data around the world.","PeriodicalId":436958,"journal":{"name":"Pertussis - Disease, Control and Challenges","volume":"70 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122257470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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