ADVANCED CLINICAL PHARMACOLOGY AND TOXICOLOGY, THERAPEUTICS最新文献

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A Prospective Study on Anti Tubercular Therapy and Management of ADR in Special Population Followed by Awareness and Suggestions on Improving Health Related Quality of Life 特殊人群抗结核治疗及不良反应管理的前瞻性研究及提高健康相关生活质量的建议

ADVANCED CLINICAL PHARMACOLOGY AND TOXICOLOGY, THERAPEUTICS Pub Date : 1900-01-01 DOI: 10.47690/ACPTT.2020.2202

Deepthi Saji, Namitha P James, Soumya Ks, Sulthana Ti

{"title":"A Prospective Study on Anti Tubercular Therapy and Management of ADR in Special Population Followed by Awareness and Suggestions on Improving Health Related Quality of Life","authors":"Deepthi Saji, Namitha P James, Soumya Ks, Sulthana Ti","doi":"10.47690/ACPTT.2020.2202","DOIUrl":"https://doi.org/10.47690/ACPTT.2020.2202","url":null,"abstract":"INTRODUCTION Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis. It is spread through the air by a person suffering from TB. A single patient can infect 10 or more people in a year [1]. Tuberculosis mostly affect adults in their most productive years. However all age groups are at risk. People who are infected with HIV are 20-30 times more likely to develop active TB. The risk of active TB is also greater in persons suffering from other conditions that impair the immune system [2-5]. Too many people have undetected tuberculosis for too long; late detection of TB increases the risk of transmitting the disease to others, having poor health outcomes, or that they and their family will suffer distress and economic hardship. The burden of TB is declining slowly worldwide, but progress in controlling TB and mitigating its consequences could be expedited if programs focused on providing early diagnosis and treatment [1-12]. A Prospective Study on Anti Tubercular Therapy and Management of ADR in Special Population Followed by Awareness and Suggestions on Improving Health Related Quality of Life","PeriodicalId":433459,"journal":{"name":"ADVANCED CLINICAL PHARMACOLOGY AND TOXICOLOGY, THERAPEUTICS","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133770119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Evidence of Possible Drug Targets and Pharmacological Management of Novel Covid-19: The World Threatening Virus 新型Covid-19:威胁世界的病毒可能的药物靶点和药理管理的临床证据

ADVANCED CLINICAL PHARMACOLOGY AND TOXICOLOGY, THERAPEUTICS Pub Date : 1900-01-01 DOI: 10.47690/ACPTT.2020.2201

V. Vidyasagar, C. Nithish

{"title":"Clinical Evidence of Possible Drug Targets and Pharmacological Management of Novel Covid-19: The World Threatening Virus","authors":"V. Vidyasagar, C. Nithish","doi":"10.47690/ACPTT.2020.2201","DOIUrl":"https://doi.org/10.47690/ACPTT.2020.2201","url":null,"abstract":"Introduction: According WHO (world health organization) viral infections (CoVID-19) spread rapidly and causing an serious issue to whole world. Coronaviruses are the major pathogens that primarily targets the human respiratory system. Previous outbreaks of coronaviruses (Covs) include the severe acute respiratory syndrome (SARS)-cov and the Middle East respiratory syndrome (MERS)-Cov which caused major impact on public health and lead to high mortality rate. The first case of covid-19 was reported in patients with pneumonia [3] in china. Aim & Objectives: To study clinical evidence of possible drug targets and pharmacological management on covid-19. Methodology: It is systematic reviews of covid-19 pandemic crisis. Discussion and Conclusion: After understanding the Viral Genome of SARS-CoV with the help of previous Studies, here we suggest the hypothetical targets to destroy CoVID-19 which includesSpike protein binding inhibition, Inhibiting Frame shifting (ORF`s) and Inhibition of nsp10/16 complex formation. As per our study we also conclude that HCQ effectively inhibited virus entry into the host cell, through changing the glycosylation of ACE-2 receptor and spike proteins. So before advice HCQ one must consider its contraindications (Retinopathy, Cardiac abnormalities, G6PD deficiency, etc). Vitamin-C shows vital role in Preventing respiratory tract infections (CoVID-19), so levels of Vitamin-C to be maintained in patients. Iron and zinc supplements to be given as they boosts immune system and inhibits viral infections respectively. Few antiviral drugs -lopinavir/ritonavir, Remdesivir shown better out comes in CoVID-19.","PeriodicalId":433459,"journal":{"name":"ADVANCED CLINICAL PHARMACOLOGY AND TOXICOLOGY, THERAPEUTICS","volume":"87 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125388452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1