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Association of HLA-DRB1 Alleles with Rheumatic Fever Among Senegalese Patients 塞内加尔患者中的 HLA-DRB1 等位基因与风湿热的关系
Annals of Proteomics and Bioinformatics Pub Date : 2023-11-20 DOI: 10.29328/journal.apb.1001022
M. Fatimata, Watt Oumar, S. Mbacke
{"title":"Association of HLA-DRB1 Alleles with Rheumatic Fever Among Senegalese Patients","authors":"M. Fatimata, Watt Oumar, S. Mbacke","doi":"10.29328/journal.apb.1001022","DOIUrl":"https://doi.org/10.29328/journal.apb.1001022","url":null,"abstract":"Background: Acute rheumatic fever (ARF) is a systemic inflammatory disease resulting from an abnormal immune response to group A β-hemolytic streptococci. ARF is a major public health problem in developing countries, particularly in Senegal. The aim of this study was to evaluate the mutation penetrance and genetic diversity of exon 2 of the HLA-DRB1 gene in Senegalese patients with ARF. Results: DNA was extracted from the blood of patients with ARF. Exon 2 of the HLA-DRB1 gene was amplified by polymerase chain reaction and sequenced using the Sanger method. Bioinformatics software and databases (polyphen-2, SIFT and ProVean) were used to assess the pathogenicity of missense mutations. The results revealed a high level of polymorphism in exon 2 of the HLA-DRB1 gene, with 73 non-synonymous mutations between codons 21 and 89, which lie in the hypervariable region encoded by exon 2. Of the 73 variants tested, 44% were pathogenic, indicating their potential involvement in ARF onset. Conclusion: Our results indicate that the HLA-DRB1 mutations involvement in the onset of rheumatic fever.","PeriodicalId":428702,"journal":{"name":"Annals of Proteomics and Bioinformatics","volume":"119 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139258922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Human Monkeypox Virus Severity 人类猴痘病毒严重程度
Annals of Proteomics and Bioinformatics Pub Date : 2023-06-16 DOI: 10.29328/journal.apb.1001021
K. Vandna, Sharma Gaurav, Mohil, Kanwar Shamsher S
{"title":"Human Monkeypox Virus Severity","authors":"K. Vandna, Sharma Gaurav, Mohil, Kanwar Shamsher S","doi":"10.29328/journal.apb.1001021","DOIUrl":"https://doi.org/10.29328/journal.apb.1001021","url":null,"abstract":"Monkeypox is a sylvatic zoonotic sickness that initially affected tropical rainforest areas in the west and vital Africa earlier than spreading to other places. Its miles carried with the aid of the Monkeypox virus member of orthopoxvirus circle of relatives. The clinical features of the infection resembles to smallpox. The primary animal to human transmission is the cause of most people of human Monkeypox ailments. Severe rodent species and non-human primates function hosts for the virus. Transmission can manifest with infected people, animals or objects into contact with bodily fluids, sores on the skin or inner mucosal surfaces just like the mouth or throat, or breathing droplets. The incubation length for Monkeypox usually lasts 6 to 13 days, even though it could last as long as 21 days. The ailment is often self-proscribing, with signs and symptoms generally clearing up on their own inside 14 to 21 days. Signs can range from moderate to extreme, and lesions may be itchy or painful. Due to the discontinuation of recurring smallpox vaccination which supplied some pass- safety in past, populations have become more liable to Monkey pox. The outbreak of Monkeypox virus due to the fact that may additionally, 2022 has created a worldwide risk of the virus. In the present review, Monkeypox epidemiology, severity, therapeutics, vaccination and its transmission to non-endemic countries has been considered. Special care and guidelines may help in the containing in the spread of the infections to the non endemic countries.","PeriodicalId":428702,"journal":{"name":"Annals of Proteomics and Bioinformatics","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134224402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advances in deep learning-based cancer outcome prediction using multi-omics data 基于多组学数据的深度学习癌症预后预测研究进展
Annals of Proteomics and Bioinformatics Pub Date : 2023-05-01 DOI: 10.29328/journal.apb.1001020
Zhou Andrew, Zhang Charlie, Eminaga Okyaz
{"title":"Advances in deep learning-based cancer outcome prediction using multi-omics data","authors":"Zhou Andrew, Zhang Charlie, Eminaga Okyaz","doi":"10.29328/journal.apb.1001020","DOIUrl":"https://doi.org/10.29328/journal.apb.1001020","url":null,"abstract":"Cancer prognosis reflects a complex biological process measured by multiple types of omics data. Deep learning frameworks have been proposed to integrate multi-omics data and predict patient outcomes in different cancer types, potentially revolutionizing cancer prognosis with superior performance. This minireview summarizes the advances in the strategies for multi-omics data integration and the performance of different deep learning models in prognosis prediction of diverse cancer types using multi-omics data published in the past 18 months. The challenges and limitations of deep learning models for predicting cancer outcomes based on multi-omics data are discussed.","PeriodicalId":428702,"journal":{"name":"Annals of Proteomics and Bioinformatics","volume":"30 2","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121000834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A brief evaluation of the concepts of omics, genomics, proteomics and metabolomics in terms of sperm cell 精子细胞组学、基因组学、蛋白质组学和代谢组学的概念综述
Annals of Proteomics and Bioinformatics Pub Date : 2023-04-24 DOI: 10.29328/journal.apb.1001019
Yörü Ahmet, Kamer Belkıs, Akarsu Serkan Ali, Ömür Ali Doğan
{"title":"A brief evaluation of the concepts of omics, genomics, proteomics and metabolomics in terms of sperm cell","authors":"Yörü Ahmet, Kamer Belkıs, Akarsu Serkan Ali, Ömür Ali Doğan","doi":"10.29328/journal.apb.1001019","DOIUrl":"https://doi.org/10.29328/journal.apb.1001019","url":null,"abstract":"The ability to live things to transfer their genetic heritage to future generations in a healthy way forms the basis of the science of reproduction. In this sense, understanding the structure and functions of the sperm cell, which is one of the sexual cells, is one of the important issues that should be emphasized. Methods such as omics, genomics, proteomics, and metabolomics, which have been found in research in recent years, are also used to evaluate the functions of the sperm cell.","PeriodicalId":428702,"journal":{"name":"Annals of Proteomics and Bioinformatics","volume":"65 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131853086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Three-phase partitioning for isolating peroxidase from lemon peels 柠檬皮中过氧化物酶的三相分离
Annals of Proteomics and Bioinformatics Pub Date : 2023-03-21 DOI: 10.29328/journal.apb.1001018
Al-Madhagi Haitham Ahmed, Yazbik Valantina, A. Wassim
{"title":"Three-phase partitioning for isolating peroxidase from lemon peels","authors":"Al-Madhagi Haitham Ahmed, Yazbik Valantina, A. Wassim","doi":"10.29328/journal.apb.1001018","DOIUrl":"https://doi.org/10.29328/journal.apb.1001018","url":null,"abstract":"Background and objective: Peroxidase is an oxidoreductase that uses different compounds as substrates and thus can be utilized for different applications. The goal of this work is to isolate peroxidase from lemon peels using Three-Phase Portioning (TPP). Methods: TPP was set by adding varying amounts of salts and alcohol and the enzyme activity recovery was measured for each variable. Different parameters were optimized successively in order to achieve the highest enzyme activity recovery including salt type, salt concentration, pH, alcohol/crude extract ratio and type of alcohol and then, combining all optimized conditions together. Results: Salt that gave maximal recovery was sodium potassium tartrate, optimal salt concentration was 15%, optimal pH was 8, optimal alcohol/crude extract ratio was 1 and t-butanol was preferred to 1-butanol. Efficiently, upon combining all optimized factors, an activity recovery of 175% was obtained. Conclusion: This protocol provides an easy, feasible method to efficiently isolate peroxidase from lemon peels using TPP.","PeriodicalId":428702,"journal":{"name":"Annals of Proteomics and Bioinformatics","volume":"79 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131563966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In silico disrupting quorum sensing of porphyromonas gingivalis via essential oils and coumarin derivatives 通过精油和香豆素衍生物在硅干扰牙龈卟啉单胞菌群体感应
Annals of Proteomics and Bioinformatics Pub Date : 2022-07-20 DOI: 10.29328/journal.apb.1001017
Al-Madhagi Haitham Ahmed, Tahan Zaher Samman
{"title":"In silico disrupting quorum sensing of porphyromonas gingivalis via essential oils and coumarin derivatives","authors":"Al-Madhagi Haitham Ahmed, Tahan Zaher Samman","doi":"10.29328/journal.apb.1001017","DOIUrl":"https://doi.org/10.29328/journal.apb.1001017","url":null,"abstract":"The emergence of porphyromonas gingivalis biofilm is a hallmark of risky burden diseases including Alzheimer's disease and atherosclerosis. The current study aims to screen some natural essential oil compounds and coumarin derivatives to interfere with quorum sensing of the bacterium and thus biofilm formation. A total of 20 ligands (10 essential oil molecules and 10 coumarin derivatives) were docked to P.gingivalis heme-binding protein HmuY using UCSF Chimera built-in AutoDock interface. Alongside, ADMET properties were also predicted via ADMETsar 2.0 and ProTox-II webservers. All of the selected ligands had higher free energy values than the reference inhibitor MES and native coumarin as well. Moreover, ADME parameters are in good agreement with Lipinski's rule of five. Nevertheless, the best molecules with top binding energy exhibited slight immunogenicity as well as carcinogenicity issues requiring in vitro confirmation. In conclusion, the tested ligands had better efficacy against P.gingivalis quorum sensing and biofilm.","PeriodicalId":428702,"journal":{"name":"Annals of Proteomics and Bioinformatics","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125235109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Short communication on Pichia pastoris vs. E. coli: Efficient expression system 毕赤酵母与大肠杆菌:高效表达系统的简要介绍
Annals of Proteomics and Bioinformatics Pub Date : 2021-09-29 DOI: 10.29328/journal.apb.1001016
Vittaladevaram Viswanath
{"title":"A Short communication on Pichia pastoris vs. E. coli: Efficient expression system","authors":"Vittaladevaram Viswanath","doi":"10.29328/journal.apb.1001016","DOIUrl":"https://doi.org/10.29328/journal.apb.1001016","url":null,"abstract":"One of the major challenges for vaccine producing companies is having favourable conditions for efficient expression system for living organisms in order to produce biologicals. Several companies across the globe looking for several alternative sources for better yield through efficient expression based system.","PeriodicalId":428702,"journal":{"name":"Annals of Proteomics and Bioinformatics","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127890256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
The dermatologic manifestations of COVID-19: a mini-review COVID-19的皮肤病学表现:综述
Annals of Proteomics and Bioinformatics Pub Date : 2021-08-27 DOI: 10.29328/journal.apb.1001015
Alharazy Sabah
{"title":"The dermatologic manifestations of COVID-19: a mini-review","authors":"Alharazy Sabah","doi":"10.29328/journal.apb.1001015","DOIUrl":"https://doi.org/10.29328/journal.apb.1001015","url":null,"abstract":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was identified in Wuhan, China, and caused coronavirus disease-19 (COVID-19), which is still a global pandemic. Dermatologic manifestations have increasingly been identified as significant extrapulmonary manifestations of COVID-19. The dermatologic manifestations associated with COVID-19 infection reported to date include maculopapular rash, vesicular lesions, urticaria-like lesions, and chilblain-like lesions. Knowledge of dermatologic manifestations of COVID-19 may be essential for early diagnosis and a better prognosis in COVID-19 patients. This review summarizes the current understanding of common COVID-19-associated dermatologic manifestations.","PeriodicalId":428702,"journal":{"name":"Annals of Proteomics and Bioinformatics","volume":"108 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133821902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The SARS CoV-2 spike domain, RGD and integrin binding effect-relationship for vaccine design strategy SARS CoV-2刺突结构域、RGD与整合素结合效应的关系及其疫苗设计策略
Annals of Proteomics and Bioinformatics Pub Date : 2021-07-20 DOI: 10.29328/journal.apb.1001014
M. Luisetto, G. Tarro, K. Edbey, Naseer Almukthar, L. Cabianca, G. Mashori, A. Ilman, Yesvi Ar, Latyschev Oy
{"title":"The SARS CoV-2 spike domain, RGD and integrin binding effect-relationship for vaccine design strategy","authors":"M. Luisetto, G. Tarro, K. Edbey, Naseer Almukthar, L. Cabianca, G. Mashori, A. Ilman, Yesvi Ar, Latyschev Oy","doi":"10.29328/journal.apb.1001014","DOIUrl":"https://doi.org/10.29328/journal.apb.1001014","url":null,"abstract":"Related the need to search new strategy in vaccine design in order to reduce also some rare effect like trombosys for some registered products it is interesting the role played by the SPIKE RGD domain. The binding with molecules like Fibronectin is a process that must to be deeply investigated. A better understanding in this process can be used to improve safety of the new generation of COVID vaccine. The rare effect like thrombosis recognized by regulatory agency produced a modification of technical data sheet of some vaccine so the phenomena Is interesting to be more investigated. Spike protein and its domains are involved in producing pathological effect of the COVID-19 disease. What it is interesting is that some pathological effect of this pathology are similar to some rare side effect produced by some COVID-19 vaccine classes. After a review of interesting literature related this topics is submitted an experimental projects able to verify in vitro the spike procoaugulant property.","PeriodicalId":428702,"journal":{"name":"Annals of Proteomics and Bioinformatics","volume":"143 4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129447054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pigeonpea sterility mosaic virus a green plague-Current status of available drug and new potential targets 鸽豌豆不育花叶病毒一种绿色瘟疫——现有药物现状及新的潜在靶点
Annals of Proteomics and Bioinformatics Pub Date : 2021-06-14 DOI: 10.29328/journal.apb.1001013
Nisha Singh, B. Narula, Megha Ujinwal, Sapna Langyan
{"title":"Pigeonpea sterility mosaic virus a green plague-Current status of available drug and new potential targets","authors":"Nisha Singh, B. Narula, Megha Ujinwal, Sapna Langyan","doi":"10.29328/journal.apb.1001013","DOIUrl":"https://doi.org/10.29328/journal.apb.1001013","url":null,"abstract":"Pigeonpea is one of the important legume crops with high protein content and nutritional traits. It has enormous potency for its widespread adoption by farming communities. It is affected by various kinds of biotic and abiotic stresses. In the context, of biotic stresses Sterility mosaic disease (SMD) is one of the severe diseases in pigeonpea which ultimately lead to the drastic yield loss. The virus belongs to the genus Emaravirus, family- Fimoviridae. SMD is associated with two diverse types of Emaravirus, Pigeonpea sterility mosaic virus1 (PPSMV-1) and Pigeonpea sterility mosaic virus 2 (PPSMV-2). It is transmitted by the mite (Aceria cajani), mainly environmental contributing to the feasibility for the mites for the inoculation of the virus. The SMD is mainly governed by two genes SV1 that includes the dominant allele and serves as an inhibitory action on the resistance of the SV2. Methods for identification of the virus include RT-PCR, DIBA and ELISA using alkaline phosphatase or penicillinase. To control SMV disease farmers generally adopted intercropping methods. There are few potential drugs have been identified for the administration of the disease such as 0.1% Fenazaquin, Dicofol, Imidacloripid, Carbosulfan; Spiromesifin includes the inhibition of the mite inoculation on the pigeonpea plant. The present review describes compressive and systematic insights on SMV protein targets and potential drugs that could be utilized as the presumed drug targets for the finding of true drugs against the SMD in pigeonpea.","PeriodicalId":428702,"journal":{"name":"Annals of Proteomics and Bioinformatics","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121082520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
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