Biofarmasi Journal of Natural Product Biochemistry最新文献

{"title":"Antioxidant and alpha-glucosidase inhibitory activities of Euchresta horsfieldii","authors":"A. I. Prihantini, Krisnawati, Ali Setyayudi","doi":"10.13057/BIOFAR/F170202","DOIUrl":"https://doi.org/10.13057/BIOFAR/F170202","url":null,"abstract":"Abstract. Prihantini AI, Krisnawati, Setyayudi A. 2019. Antioxidant and alpha-glucosidase inhibitory activities of Euchresta horsfieldii. Biofarmasi J Nat Prod Biochem 17: 61-64. Euchresta horsfieldii, known as pranajiwa, is a medicinal plant that is widely grown in Bali and West Nusa Tenggara, Indonesia. Its seeds or fruits are commonly used for body freshness and stamina. The present study aimed to investigate the biological activities of leaves, root, stem, fruits, seeds of the E. horsfieldii. Antioxidant, alpha-glucosidase inhibitory activities and total phenolic compound were evaluated from methanolic extracts of all parts of E. horsfieldii. The result showed that leaf extract of E. horsfieldii exhibited the highest antioxidant activity with IC50 215.11±08.06 µg/mL. Meanwhile, the root extract had the highest alpha-glucosidase inhibitory activity and total phenolic compound with IC50 29.76±13.17 µg/mL and 763±0.01 mg GAE/100mg dry extract, respectively. In conclusion, the study suggested that E. horsfieldii is potential as natural source of antioxidant and alpha-glucosidase inhibitor agents.","PeriodicalId":426718,"journal":{"name":"Biofarmasi Journal of Natural Product Biochemistry","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122061311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutritional value and safety of castor bean (Ricinus communis) seeds detoxified in solid-state fermentation by Pleurotus ostreatus","authors":"Oluwafolakemi Christianah Adebayo, C. O. Ogidi, B. Akinyele","doi":"10.13057/BIOFAR/F170201","DOIUrl":"https://doi.org/10.13057/BIOFAR/F170201","url":null,"abstract":"Abstract. Adebayo OC, Ogidi CO, Akinyele BJ. 2019. Nutritional value and safety of castor bean (Ricinus communis) seed detoxified in solid-state fermentation by Pleurotus ostreatus. Biofarmasi J Nat Prod Biochem 17: 51-60. The nutrient and antinutrient contents of unfermented castor seeds (UCS), castor seeds fermented with Pleurotus ostreatus (CPF) and “Ogiri,” a naturally fermented condiment from castor seeds (CSF) were determined. Proximate analyses of all the samples were carried out using methods of Association of Official Agricultural Chemists. The biosafety of the samples was carried out using the animal model. The raw castor seeds (UCS) had the highest carbohydrate (61.04%), ash (6.02%), fats (6.65%), fiber (6.62%), and calcium (0.30 mg/100g). Castor seeds fermented with Pleurotus ostreatus (CPF) had the highest protein content of 20.47%, magnesium of 7.16 mg/100g, alkaloids (7.40 mg/g) and saponins (6.69 mg/g) . CSF had the highest zinc (0.69 mg/100g). CPF had the lowest tannin (0.05 mg/g). All the essential amino acids increased significantly in the fermented samples. Tryptophan was absent in UCS but present in CSF and CPF with values of 0.78 mg/100g and 1.15 mg/100g, respectively. The hematological analysis of the rats fed CPF had the highest WBC of 5.43×109, which indicated a positive immunomodulatory effect. Hence, this study revealed that Pleurotus ostreatus degraded the toxic compounds in castor seeds to a large extent and enhanced the nutritional contents of the final product.","PeriodicalId":426718,"journal":{"name":"Biofarmasi Journal of Natural Product Biochemistry","volume":"92 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124587990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The potential of white-oyster mushroom (Pleurotus ostreatus) as antimicrobial and natural antioxidant","authors":"Saat Egra, I. Kusuma, E. Arung, H. Kuspradini","doi":"10.13057/biofar/f170102","DOIUrl":"https://doi.org/10.13057/biofar/f170102","url":null,"abstract":"Abstract. Egra S, Kusuma IW, Arung ET, Kuspradini H. 2018. The potential of white-oyster mushroom (Pleurotus ostreatus) as antimicrobial and natural antioxidant. Biofarmasi J Nat Prod Biochem 16: 17-23. White-oyster mushroom (Pleurotus ostreatus) is a favorite meal in Indonesia. Previously this fungus was known as a useless plant, but after the nutrition is known, everything changes. People tried to cultivate it because the nutrients contents are very good for body health. Therefore, to support this added value in the field of health, especially antimicrobials and antioxidants, this research needs to be done. This research used successive extraction with hexane solvent, acetate ethyl, ethanol, water, and crude ethanol by antimicrobial assay, antioxidants assay (DPPH), total antioxidant content, total phenolic content. The highest results on barrier antimicrobial test which occurred against Candida albicans bacteria was 47.60 % with 100 ppm concentration. While, on antimicrobial assay using Propionibacterium acnes bacteria, there was no significant inhibition. Regarding the antioxidant test against DPPH, the result showed the occurrence of free radical by 25 % on water extraction at the concentration of 100 ppm. Continuously, the total antioxidant content assay showed the ethyl acetate had the highest value of 368.708 mg gae/g. The results of the total content phenolic assay showed the solvent hexane had the value of 78.495 mg gae/g. These findings indicated that mushroom has an active phenolic compound with no contribution to impede its working on Candida albicans assay.","PeriodicalId":426718,"journal":{"name":"Biofarmasi Journal of Natural Product Biochemistry","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117216483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutritional composition of aquatic plants and their potential for use as animal feed: A case study of the Lower Volta Basin, Ghana","authors":"Wemegah Joshua Etse, T. Annang, J. Ayivor","doi":"10.13057/BIOFAR/F160205","DOIUrl":"https://doi.org/10.13057/BIOFAR/F160205","url":null,"abstract":"Etse WJ, Annang T, Ayivor JS. 2018. Nutritional composition of aquatic plants and their potential for use as animal feed: a case study of the Lower Volta Basin, Ghana. Biofarmasi J Nat Prod Biochem 9: 99-112. The study was conducted to determine the nutritional composition of selected dominant aquatic plants and their significant effect on the chemical and physical characteristics of the water. Aquatic plants namely Nymphaea lotus, Typha australis, Ipomoea aquatica, and Scirpus cubensis were collected, identified and authenticated at the Ghana Herbarium. The proximate nutritional compositions of these plants were measured using the standard procedure outlined in the Association of Official Analytical Chemist (AOAC 2002). Water and sediment quality analyses of some physicochemical variables were also carried out using processes described in the standard methods for water and wastewater examination. The results showed that nutrient composition such as the crude protein, ether extracts, ash content, and nitrogen-free extracts was significantly higher than the corresponding constituents in Panicum maximum used as a control for the study. The findings also indicated that levels of heavy metals in all plants fell within the WHO/FAO standards for metals in vegetables and food. The effects of the physicochemical parameter of water also revealed that pH, nitrate, turbidity, DO, and BOD levels were found significantly different from the control site. The level of heavy metal in the sediment samples revealed significant variations in the distribution of the metals, with Zn showing the most significant difference and Pb the least with a mean level of 7.5±0.86 mg/L and 0.4±0.03 mg/L respectively. These plant species suggests having a high nutritive potential and indicates their possible use as mixed ingredients in animal feed. Exploitation of these aquatic plants for animal feed would be a step towards better utilization of these plants help in the management of aquatic plants within the basin.","PeriodicalId":426718,"journal":{"name":"Biofarmasi Journal of Natural Product Biochemistry","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128727922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The hydroxyproline content of fish bone gelatin from Indonesian Pangasius catfish by enzymatic hydrolysis for producing the bioactive peptide","authors":"Y. Atma, H. Lioe, E. Prangdimurti, Hermawan Seftiono, M. Taufik, Dita Fitriani, A. Z. Mustopa","doi":"10.13057/BIOFAR/F160202","DOIUrl":"https://doi.org/10.13057/BIOFAR/F160202","url":null,"abstract":"Abstract. Atma Y, Lioe HN, Prangdimurti E, Seftiono H, Tahufik M, Fitriani D, Mustopa AZ. 2018. The hydroxyproline content on fish bone gelatin from Indonesian Pangasius catfish by enzymatic hydrolysis for producing of bioactive peptide. Biofarmasi J Nat Prod Biochem 16: 64-68. Gelatins has been widely used in food, medicines, cosmetics, photography industries. In the food industry, gelatin used as food additives and functional foods. The applications of gelatin as a functional food due to their bioactivity in a form of peptides. Bioactive peptides from gelatin are mostly obtained through enzymatic hydrolysis processes. This study was conducted to measure the hydroxyproline content of gelatin bone of Indonesian Pangasius catfish (Pangasius sutchi) before and after enzymatic hydrolysis. The hydroxyproline is one of the dominant amino acids in gelatin. Gelatin hydrolysis was carried out using a flavourzyme at concentration of 6% and the incubation series of 0, 4, 6 and 8 hours. The standard concentration of hydroxyproline was used in range of 0-1 μg. The results showed that the linear curve of the hydroxyproline standard solution was y=0.0554x+0.0406, with the coefficient of determination (R²) = 0.9435. The incubation time of enzymatic hydrolysis (6% enzyme concentration) affected the hydroxyproline content. The hydroxyproline from fish bone gelatin was 18.91±2.87 mg/mL, 63.81±1.28 mg/mL, 46.21±1.28 mg/mL and 37.64 ± 0.64 mg/mL respectively during 0, 4, 6 dan 8 h incubation time. This hydroxyproline content was significantly different at 95% confidence level from each treatment time.","PeriodicalId":426718,"journal":{"name":"Biofarmasi Journal of Natural Product Biochemistry","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132604530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of jengkol (Archidendron pauciflorum) fruit peel ethanolic extract to heart histologic of rat induced by streptozotocin","authors":"Selma Alamanda Abadi, Zulfa Illiyyin, Jasmine Raissa Rachmadina, D. Malini","doi":"10.13057/BIOFAR/F160201","DOIUrl":"https://doi.org/10.13057/BIOFAR/F160201","url":null,"abstract":"Abadi SA, Illiyyin Z, Rachmadina JR, Malini DM. 2018. The effect of jengkol (Archidendron pauciflorum) fruit peel ethanolic extract to heart histologic of rat induced by streptozotocin. Biofarmasi J Nat Prod Biochem 16: 59-63. Indonesia is ranked 7th out of 10 countries with the highest diabetic patients in the world. Diabetes mellitus is a disease that can cause heart disorders and adults who suffer from DM are four times more likely to develop heart disease. Jengkol fruit peel has been used traditionally as a drug for diabetes mellitus. The aim of this research was to know the effect of fruit peel ethanolic extract of jengkol (Archidendron pauciflorum) (JFPEE) on rat (Rattus norvegicus) heart histological structure and to obtain effective dose from JFPEE. This research used experimental method in laboratory with Completely Random Design (CRD) using 6 treatments and 4 replications. Treatment was given for 14 consecutive days consisting of negative control, positive control, comparison (glibenclamide dose 10 mg/kg BW), P1, P2, and P3 (JFPEE dose 385, 770, and 1.540 mg/kg BW). Diabetic induction was performed with streptozotocin dose 65 mg/kg BW in female wistar rat except for negative control group. The parameters that observed were number of necrosis and cell damage score, including fat degeneration, hydropic degeneration, and inflammatory cell. The obtained data were analyzed by ANOVA-Tukey's test with 95% confidence level using SPSS version 21 for Windows. The result of histological structure showed that number of necrosis and cell damage score in group of rats treated with JFPEE dose 385 mg/kg BW (174.25±6.34; 1.25±0.50) were not significantly different from the negative control rats (172.00±7.62; 1.00±0.00). The effective dose of JFPEE that can repair the damage of heart cell’s rat induced by streptozotocin was 385 mg/kg BW.","PeriodicalId":426718,"journal":{"name":"Biofarmasi Journal of Natural Product Biochemistry","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133882939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of flavonoids from candidate striga grass in controlling diet legumes Cicer arietinum and Vigna radiata","authors":"Anyango Anna Akumu, Hudson Nyambaka, S. P. Kuate, B. Torto","doi":"10.13057/BIOFAR/F160204","DOIUrl":"https://doi.org/10.13057/BIOFAR/F160204","url":null,"abstract":"Akumu AA, Nyambaka H, Kuate SP, Torto B.2018. Characterization of flavonoids from candidate striga grass in controlling diet legumes Cicer arietinum and Vigna radiata.Biofarmasi J Nat Prod Biochem 16: 83-98. In Africa, intercropping of some legumes with cereal plants has been noticed to generate exceptional reduction of Striga invasion and enhanced production of cereal crop. Desmodium uncinatum administers Striga invasion in intercrop with cereals through an allelopathic technique, which includes postsprouting accretion inhibitors emanated from the roots. Having a potential to be a new technique for grass administering, Allelopathy is a natural and environmentally friendly method. A standardized profiling technique based on Reverse Phase-High Performance Liquid Chromatography (RP-HPLC) and Liquid Chromatography coupled with Mass Spectrometry (LC/MS) was utilized to determine flavonoids in extracts of chickpea (Cicer arietinum) and mung bean (Vigna radiata), potential trap plants for Striga grass. Nine flavonoids involving mono-and diglycosyl derivatives of fisetin, baicalein, rhamnetin, isorhamnetin, formononetin, quercetin, isosakuranetin, and sakuranetin were temporarily distinguished. The obtained phenolics were available at concentrations higher than 0.001% of the dry materials. Many of these phenolic mixtures have been claimed to possess human health advantages. These glycosylated flavones are noted for the first time in these two species. The comprehensive analysis of the polar secondary metabolites in these leguminous plants was useful for comprehending their inhibitory chemistry and proposed biosynthesis by C-glucoside characteristics. All the segregated and described mixtures in the diet legume C. arietinum were O-glucosylated. While, Food legume V. radiata should be observed further to see if it can attain Desmodium’s allelopathic ability since it possesses inhibitory chemistry and proposed biosynthesis by C-glucosylation.","PeriodicalId":426718,"journal":{"name":"Biofarmasi Journal of Natural Product Biochemistry","volume":"197 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114420842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of antimicrobial and antioxidant attributes of Tanzanian honey from two agro-ecological areas","authors":"Flora Thomas Luvanda, M. Lyimo","doi":"10.13057/BIOFAR/F160203","DOIUrl":"https://doi.org/10.13057/BIOFAR/F160203","url":null,"abstract":"Luvanda FT, Lyimo ME. 2018. Evaluation of antimicrobial and antioxidant attributes of Tanzanian honey from two agroecological areas. Biofarmasi J Nat Prod Biochem 16: 69-82. In order to appraise the characteristic of Tanzanian honey based on antioxidant attributes and antimicrobial activity on bacteria and fungi in relation to its physicochemical attributes, the study was conducted. The examined honey was sampled from two kinds of bees namely stinging and stingless honey bees and was gathered from the western area (Tabora and Shinyanga) and the central area (Singida and Dodoma). They were examined for their antimicrobial activity, anti-oxidant attributes (total phenol, vitamin C) and physicochemical attributes of pH, color, pH, sugar, and minerals. 54 % of tested honey samples inhibited microbial growth but the remaining 46% did not inhibit the growth. Microbial impediment areas range from 8.5 to 14.16 mm (stinging honey bee) and 10.56-15.13 mm (stingless honey bee). Honey yielded by stinging honey bee in the cities of Shinyanga, Bukombe, and Nzega and the cities of Singida and Issuna is more effective in impeding microbial growth than that of other cities. Candida albicans is more sensitive (23.1%) to honey of stingless honey bee, followed by Staphylococcus saprophyticus (33%), Salmonella typhi (32%), Escherichia coli (19.2%) and Aspergillus flavus (16.0%). The substance of antioxidant, total phenol and vitamin C in honey of stingless honey bee were importantly (P <0.05) higher than that of honey of stinging honey bee. Antioxidants (FRAP) ranged from 322.16-973.57 µMFe (II) /100g, total phenols was from 13.87-33.55 mg /100g and vitamin C was from 2.54-10.99 mg /100. At pH value, there was no substantial dissimilarity (P> 0.05) between the two samples of honey. Potassium possesses the highest value while Zn possesses the lowest value in samples of honey of stinging and stingless honey bee. The gradation color of honey of stingless honey bee ranged from extra light amber-light amber while that of honey of stinging bee ranged from white water-light amber. There was a positive and substantial correlation (P <0.001) between the color of honey, antioxidants, total phenol, and mineral substance. Stingless honey bee's honey from the western region is superior to stinging honey bee's honey in antioxidant and antimicrobial attributes and therefore is prompted to be utilized as a valuable diet product, preventive and curative medicine.","PeriodicalId":426718,"journal":{"name":"Biofarmasi Journal of Natural Product Biochemistry","volume":"263 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124292760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}