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Journal of Clinical Research and Analytical Reviews最新文献

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Study of Angiogenesis in Experiment 血管生成的实验研究
Journal of Clinical Research and Analytical Reviews Pub Date : 2022-03-05 DOI: 10.56391/jcrar.2022.1020
Bon Elizaveta
{"title":"Study of Angiogenesis in Experiment","authors":"Bon Elizaveta","doi":"10.56391/jcrar.2022.1020","DOIUrl":"https://doi.org/10.56391/jcrar.2022.1020","url":null,"abstract":"The creation of new blood vessels is referred to as angiogenesis. Endothelial cells, which line the inside wall of blood arteries, migrate, proliferate, and differentiate during this process. Chemical cues in the body influence the process of angiogenesis. This study intends to highlight the expression of various angiogenic indicators throughout various diseases, the involvement of pro-angiogenic and anti-angiogenic factors during angiogenesis, and the use of angiogenic inhibitors during antiangiogenic therapy, particularly in cancer.","PeriodicalId":426537,"journal":{"name":"Journal of Clinical Research and Analytical Reviews","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117063574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In Silico Development of Anticancer Drugs 抗癌药物的发展
Journal of Clinical Research and Analytical Reviews Pub Date : 2022-03-05 DOI: 10.56391/jcrar.2022.1019
Vikrant Verma
{"title":"In Silico Development of Anticancer Drugs","authors":"Vikrant Verma","doi":"10.56391/jcrar.2022.1019","DOIUrl":"https://doi.org/10.56391/jcrar.2022.1019","url":null,"abstract":"The development of new drugs has been recognised as a complex, costly, time-consuming, and difficult enterprise. A new medication discovery via typical drugdevelopment pipeline is predicted to take around 12 years and 2.7 billion USD on average. Methods to cut research costs and accelerate the development process of new drugs has become a difficult and pressing topic for the pharmaceutical sector. Computer-aided drug discovery (CADD) has developed as a potent and promising technique for designing drugs that are quicker, cheaper, and more effective. Recently, the fast development of computational techniques for drug discovery, particularly anticancertherapies, has had a substantial and exceptional influence on anticancer medication design, as well as beneficial insights into the field of cancer therapy.This article describes docking of Crizotinib, Sunitinibmalate, and their analogues with the Anaplastic lymphoma kinase receptor.On docking with the Anaplastic lymphoma kinase receptor, Crizotinib and Sunitinibmalate yielded energy values of -9.85 and -8.25, respectively.","PeriodicalId":426537,"journal":{"name":"Journal of Clinical Research and Analytical Reviews","volume":"57 1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126128986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Updating an Electrostatics-Based Perspective in View of the Enhanced Infectivity of SARS-CoV-2 Variants SARS-CoV-2变异体增强传染性的静电视角更新
Journal of Clinical Research and Analytical Reviews Pub Date : 2022-03-05 DOI: 10.56391/jcrar.2022.1021
F. Lattarulo
{"title":"Updating an Electrostatics-Based Perspective in View of the Enhanced Infectivity of SARS-CoV-2 Variants","authors":"F. Lattarulo","doi":"10.56391/jcrar.2022.1021","DOIUrl":"https://doi.org/10.56391/jcrar.2022.1021","url":null,"abstract":"The static electric field continuously surrounding a human body because it is subject to tribocharge buildup can play a key role in the control of the external viral entry mechanism. This phenomenon could be promoted by the electrostatically induced migration of charge-loaded harmful airborne. On the other side, the same field might be beneficial as a natural means of reducing the spike/host cell affinity, hence, of preventing the adverse effects of infection after the viral entry. The paper draws attention to the above complex phenomenology, the implications of which can be ambivalent, as a further contribution to updating a previous investigation.","PeriodicalId":426537,"journal":{"name":"Journal of Clinical Research and Analytical Reviews","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121124863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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