‘The Terminator’ – Neutrophils in respiratory disease最新文献

S96 Neutrophil metabolism is reprogrammed in patients with acute respiratory distress syndrome S96急性呼吸窘迫综合征患者中性粒细胞代谢重编程

‘The Terminator’ – Neutrophils in respiratory disease Pub Date : 2022-11-01 DOI: 10.1136/thorax-2022-btsabstracts.102

Gm Cooper, P. Sadiku, DM Griffith, S. Walmsley

引用次数: 0

S97 Neutrophil epigenetic signatures in the context of acute respiratory distress syndrome 急性呼吸窘迫综合征背景下的中性粒细胞表观遗传特征

‘The Terminator’ – Neutrophils in respiratory disease Pub Date : 2022-11-01 DOI: 10.1136/thorax-2022-btsabstracts.103

X. Xu, P. Sadiku, D. Griffith, Mayra A. Sánchez-García, S. Walmsley

引用次数: 0

S95 Prolonged neutrophil dysfunction and phenotype in elderly hospitalised community acquired pneumonia patients S95老年社区获得性肺炎住院患者中性粒细胞延长功能障碍及表型

‘The Terminator’ – Neutrophils in respiratory disease Pub Date : 2022-11-01 DOI: 10.1136/thorax-2022-btsabstracts.101

A. Faniyi, O. Thein, K. Belchamber, D. Parekh, A. Scott, E. Sapey, D. Thickett

引用次数: 0

S94 Dysfunctional neutrophil response in COVID-19 infection vary by subtype S94 COVID-19感染中中性粒细胞反应功能失调因亚型而异

‘The Terminator’ – Neutrophils in respiratory disease Pub Date : 2022-11-01 DOI: 10.1136/thorax-2022-btsabstracts.100

O. Thein, K. Belchamber, A. Faniyi, J. Hazeldine, F. Grudzinska, MJ Hughes, AE Jasper, L. Crowley, K. Yip, S. Lugg, E. Sapey, D. Parekh, D. Thickett, A. Scott

{"title":"S94 Dysfunctional neutrophil response in COVID-19 infection vary by subtype","authors":"O. Thein, K. Belchamber, A. Faniyi, J. Hazeldine, F. Grudzinska, MJ Hughes, AE Jasper, L. Crowley, K. Yip, S. Lugg, E. Sapey, D. Parekh, D. Thickett, A. Scott","doi":"10.1136/thorax-2022-btsabstracts.100","DOIUrl":"https://doi.org/10.1136/thorax-2022-btsabstracts.100","url":null,"abstract":"S94 Figure 1Comparison of neutrophil effector functions between COVID-19 variants (alpha n=33, delta n=13, omicron n-14). A.% change in phagocytosis significantly increased between alpha and delta patients (p=0.0162). B. Fold change in cells migrated through a transwell pore to IL8 compared to vehicle control significantly reduced in omicron patients compared alpha and delta (vs alpha p=0.0018, vs delta p=0.0370). C. Neutrophil extracellular trap production after stimulation with PMA compared to vehicle control significantly reduced in omicron patients compared to alpha (p=0.0396)[Figure omitted. See PDF]DiscussionOur results showing changes in neutrophil „function and phenotype differ between variants of COVID-19 infection, potentially reflect viral evolution. This change in neutrophil function may contribute to the evolving clinical phenotype observed in patients. Our population of ward-based COVID-19 patients represents the majority of inpatient hospital burden where early intervention may prevent clinical deterioration. Targeting neutrophil function may be an effective way of improving infection outcome in the future.ReferenceBelchamber K, et al. Altered neutrophil phenotype and function in non-ICU hospitalised COVID-19 patients correlated with disease severity. medRxiv, 2021: p. 2021.06.08.21258535.","PeriodicalId":426518,"journal":{"name":"‘The Terminator’ – Neutrophils in respiratory disease","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125734715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0