Infrared Spectroscopy - Principles, Advances, and Applications最新文献

Mid-Infrared Laser Spectroscopy Applications I: Detection of Traces of High Explosives on Reflective and Matte Substrates 中红外激光光谱学应用ⅰ:探测反射和哑光基材上的烈性炸药痕迹

Infrared Spectroscopy - Principles, Advances, and Applications Pub Date : 2018-12-07 DOI: 10.5772/INTECHOPEN.81923

L. Pacheco‐Londoño, J. Castro-Suarez, Nataly J. Galán‐Freyle, Amanda M. Figueroa-Navedo, J. L. Ruiz-Caballero, Ricardo Infante-Castillo, S. Hernández‐Rivera

引用次数: 4

Mid-Infrared Laser Spectroscopy Applications in Process Analytical Technology: Cleaning Validation, Microorganisms, and Active Pharmaceutical Ingredients in Formulations 中红外激光光谱在过程分析技术中的应用:清洁验证、微生物和配方中的活性药物成分

Infrared Spectroscopy - Principles, Advances, and Applications Pub Date : 2018-12-07 DOI: 10.5772/INTECHOPEN.82402

L. Pacheco‐Londoño, Nataly J. Galán‐Freyle, Amira C. Padilla-Jiménez, J. Castro-Suarez, Amanda M. Figueroa-Navedo, J. L. Ruiz-Caballero, Ricardo Infante-Castillo, C. Rios-Velazquez, S. Hernández‐Rivera

{"title":"Mid-Infrared Laser Spectroscopy Applications in Process Analytical Technology: Cleaning Validation, Microorganisms, and Active Pharmaceutical Ingredients in Formulations","authors":"L. Pacheco‐Londoño, Nataly J. Galán‐Freyle, Amira C. Padilla-Jiménez, J. Castro-Suarez, Amanda M. Figueroa-Navedo, J. L. Ruiz-Caballero, Ricardo Infante-Castillo, C. Rios-Velazquez, S. Hernández‐Rivera","doi":"10.5772/INTECHOPEN.82402","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.82402","url":null,"abstract":"Mid-infrared (MIR) lasers are very high-brightness energy sources that are replacing conventional thermal sources (globars) in many infrared spectroscopy (IRS) techniques. Although not all laser properties have been exploited in depth, properties such as collimation, polarization, high brightness, and very high resolution have contributed to recast IRS tools. Applications of MIR laser spectroscopy to process analytical technology (PAT) are numerous and important. As an example, a compact grazing angle probe mount has allowed coupling to a MIR quantum cascade laser (QCL), enabling reflectance-absorbance infrared spectroscopy (RAIRS) measurements. This methodology, coupled to powerful multivariable analysis (MVA) routines of chemometrics and fast Fourier transform (FFT) preprocessing of the data resulted in very low limits of detection of active pharmaceutical ingredients (APIs) and high explosives (HEs) reaching trace levels. This methodology can be used to measure concentrations of surface contaminants for validation of cleanliness of pharmaceutical and biotechnology processing batch reactors and other manufacturing vessels. Another application discussed concerns the enhanced detection of microorganisms that can be encountered in pharmaceutical and biotechnology plants as contaminants and that could also be used as weapons of mass destruction in biological warfare. In the last application discussed, the concentration of APIs in formulations was determined by MIR laser spectroscopy and was cross validated with high-performance liquid chromatography.","PeriodicalId":426448,"journal":{"name":"Infrared Spectroscopy - Principles, Advances, and Applications","volume":"123 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128811367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Introductory Chapter: Infrared Spectroscopy - A Synopsis of the Fundamentals and Applications 导论章:红外光谱学-基本原理和应用简介

Infrared Spectroscopy - Principles, Advances, and Applications Pub Date : 2018-11-19 DOI: 10.5772/INTECHOPEN.82210

Marwa El-Azazy

引用次数: 5

Mid-Infrared Spectroscopy and Challenges in Industrial Environment 中红外光谱及其在工业环境中的挑战

Infrared Spectroscopy - Principles, Advances, and Applications Pub Date : 2018-11-17 DOI: 10.5772/INTECHOPEN.80657

C. Mitra

引用次数: 5

Application of Visible to Near-Infrared Spectroscopy for Non-Destructive Assessment of Quality Parameters of Fruit 可见光与近红外光谱在水果品质参数无损评价中的应用

Infrared Spectroscopy - Principles, Advances, and Applications Pub Date : 2018-11-05 DOI: 10.5772/INTECHOPEN.80069

K. Ncama, Lembe S. Magwaza, A. Mditshwa, S. Tesfay

{"title":"Application of Visible to Near-Infrared Spectroscopy for Non-Destructive Assessment of Quality Parameters of Fruit","authors":"K. Ncama, Lembe S. Magwaza, A. Mditshwa, S. Tesfay","doi":"10.5772/INTECHOPEN.80069","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.80069","url":null,"abstract":"The accuracy and robustness of prediction models are very important to the successful commercial application of visible to near-infrared spectroscopy (VisNIRS) on fruit. The difference in physiological characteristics of fruit is very wide, which necessitates variance in the type of spectrometers applied to collect spectral data, pre-processing of the collected data and chemometric techniques used to develop robust models. Relevant practices of data collection, processing and the development of models are a challenge because of the required knowledge of fruit physiology in addition to the Vis-NIRS expertise of a researcher. This chapter deals with the application of Vis-NIRS on fruit by discussing commonly used spectrometers, data chemometric treatment and common models developed for assessing quality of specific types of fruit. The chapter intends to create an overview of commonly used techniques for guiding general users of these techniques. Current status, gaps and future perspectives of the application of Vis-NIRS on fruit are also discussed for challenging researchers who are experts in this research field.","PeriodicalId":426448,"journal":{"name":"Infrared Spectroscopy - Principles, Advances, and Applications","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116442581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

IR-Spectroscopy of Radiation- Stimulated Processes of Adsorption, Radiolysis, and Hydrogenation on the Surface of Metals in Contact with Hydrocarbons 与碳氢化合物接触的金属表面受辐射刺激的吸附、辐射分解和加氢过程的红外光谱

Infrared Spectroscopy - Principles, Advances, and Applications Pub Date : 2018-11-05 DOI: 10.5772/INTECHOPEN.80431

N. Gadzhieva

引用次数: 0

Applications of Infrared Spectroscopy and Microscopy in Diagnosis of Obesity 红外光谱和显微技术在肥胖症诊断中的应用

Infrared Spectroscopy - Principles, Advances, and Applications Pub Date : 2018-11-05 DOI: 10.5772/INTECHOPEN.81216

Ayca Dogan Mollaoglu, I. Ozyurt, F. Severcan

{"title":"Applications of Infrared Spectroscopy and Microscopy in Diagnosis of Obesity","authors":"Ayca Dogan Mollaoglu, I. Ozyurt, F. Severcan","doi":"10.5772/INTECHOPEN.81216","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.81216","url":null,"abstract":"Infrared (IR) spectroscopy is a vibrational spectroscopic technique based on the absorption of infrared radiation by matters that excite vibrations of molecular bonds. It is a powerful method for investigating structural, functional, and compositional changes in biomolecules, cells, and tissues. In recent years, scientific researchers have continued to increase the performance of this technique on clinical cases such as cancers and metabolic disorders. Obesity is one of the main factors that increases the risk of many diseases and contributes to functional disabilities in tissues such as adipose, liver, and muscle. Applications of IR spectroscopic techniques allow identifying molecular changes due to obesity, to understand the molecular mechanism of the disease, to identify specific spectral biomarkers that can be used in diagnosis. In addition, these spectral biomarkers can be used to identify the appropriate drugs and their doses for treatment. In this chapter, applications of IR spectroscopic and microscopic techniques to the characterization and understanding the obesity metabolism will be presented. The discriminatory power of these techniques in diagnosis of obesity will be discussed. In future, these novel approaches will shed light on the internal diagnosis of obesity in clinical application.","PeriodicalId":426448,"journal":{"name":"Infrared Spectroscopy - Principles, Advances, and Applications","volume":"74 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131531193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Application of Infrared Spectroscopy in Catalysis: Impacts on Catalysts’ Selectivity 红外光谱在催化中的应用:对催化剂选择性的影响

Infrared Spectroscopy - Principles, Advances, and Applications Pub Date : 2018-11-05 DOI: 10.5772/INTECHOPEN.80524

P. Concepción

引用次数: 2