Prevention, Detection and Management of Oral Cancer最新文献

Introductory Chapter: Head and Neck Cancer 导论章:头颈癌

Prevention, Detection and Management of Oral Cancer Pub Date : 2019-12-11 DOI: 10.5772/intechopen.86272

S. Sundaresan, P. Rajapriya

引用次数: 0

Management Strategies for Oral Cancer Subsites 口腔癌亚位点的管理策略

Prevention, Detection and Management of Oral Cancer Pub Date : 2019-10-23 DOI: 10.5772/intechopen.81555

N. Gupta, M. Mahajan, A. Hore

{"title":"Management Strategies for Oral Cancer Subsites","authors":"N. Gupta, M. Mahajan, A. Hore","doi":"10.5772/intechopen.81555","DOIUrl":"https://doi.org/10.5772/intechopen.81555","url":null,"abstract":"Oral cancers are the most common cancers in India, especially in males. This can be attrib - uted primarily to consumption of tobacco and areca related products. Surgery is the mainstay of treatment for oral cancers with subtle subsite-specific nuances. The oral cavity starts at the mucocutaneous junction of the lips (the vermilion border) extending posteriorly to the junction of the hard and soft palate superiorly, anterior fauces laterally and the junction of the anterior two-thirds and posterior third of the tongue inferiorly. The oral cavity is lined by stratified squamous epithelium of varying degrees of keratinization. Primary tumors of the oral cavity may be derived from the mucosa, salivary glands, neurovascular tissues, bone or dental tissues. Over 90% of malignant tumors of the oral cavity are squamous cell carcinomas. There are certain basic principles of oncology, those hold true, despite the disease subsite and pathology. Stage I and II disease should be dealt with single modality treat- ment, whereas Stage III and IV warrant combined modality approach. Choice of modality (surgical versus non-surgical), depends on intent of treatment, chances of cure, accessibility and resectability of disease, impact on quality of life and patient’s general health profile.","PeriodicalId":426400,"journal":{"name":"Prevention, Detection and Management of Oral Cancer","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129346689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The Mechanisms of Proliferation and Energy Metabolism in Oral Cancer 口腔癌的增殖和能量代谢机制

Prevention, Detection and Management of Oral Cancer Pub Date : 2019-06-25 DOI: 10.5772/INTECHOPEN.87091

M. Fukuda, H. Sakashita

{"title":"The Mechanisms of Proliferation and Energy Metabolism in Oral Cancer","authors":"M. Fukuda, H. Sakashita","doi":"10.5772/INTECHOPEN.87091","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.87091","url":null,"abstract":"Human oral squamous cell carcinoma (HOSCC) is the most common head and neck malignant neoplasm. Therapy is generally performed in multidisciplinary approach that used chemotherapy, radiotherapy, and surgery against patients with oral cancer; however, we cannot avoid dysfunction due to its side effects or surgical defects, and it significantly impacts the postoperative quality of life, unfortunately. Therefore, a bet - ter understanding of the molecular mechanisms driving oral carcinogenesis may lead to new diagnostic and therapeutic approaches to this disease and improve the prognosis of HOSCC patients. Cancer cells process a fundamental change in its bioenergetics metabo lism from normal cells on an altered glucose and lipid metabolism. Recent insights into tumor metabolism have further revealed that oncogenic signaling pathways directly promote metabolic reprogramming to upregulate biosynthesis of lipids, carbohydrates, protein, DNA, and RNA, leading to enhanced growth of tumors. Therefore, targeting cell metabolism has become a novel direction for drug development in oncology. Moreover, molecular mechanisms causing these metabolic changes are just starting to be unraveled. This chapter presents recent findings on molecular markers that have been involved in the mechanisms of proliferation and energy metabolism of oral cancer and in addition provides new perspectives on oral cancer diagnosis and treatments.","PeriodicalId":426400,"journal":{"name":"Prevention, Detection and Management of Oral Cancer","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124937955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Laser Dental Treatment Techniques 激光牙科治疗技术

Prevention, Detection and Management of Oral Cancer Pub Date : 2019-01-08 DOI: 10.5772/INTECHOPEN.80029

Zahra Al Timimi, Mohammed Saleem Ismail Alhabeel

引用次数: 6

Early Detection and Multidisciplinary Approach to Oral Cancer Patients 口腔癌患者的早期发现和多学科方法

Prevention, Detection and Management of Oral Cancer Pub Date : 2018-11-05 DOI: 10.5772/INTECHOPEN.81126

N. Akbulut, A. Altan

{"title":"Early Detection and Multidisciplinary Approach to Oral Cancer Patients","authors":"N. Akbulut, A. Altan","doi":"10.5772/INTECHOPEN.81126","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.81126","url":null,"abstract":"“Oral cancer” is a term usually describing oral cavity and oropharyngeal malign tumors. The most histologic type of carcinoma is squamous cell carcinoma, seen in oral and oropharyngeal region with the incidence of 90%. Prevention or early diagnosis of prema- lignant and oral cancer requires increased public awareness and educating practitioners to be skillful in identifying oropharyngeal region pathology. To prevent oral cancers, the etiological factors should be known, and measures must be taken according to those factors. Premalignant lesions are leukoplakia, lichen planus in oral and cutaneous form, erythroplakia, stomatitis nicotina , and submucous fibrosis. Premalignant lesions should be treated, if possible, or followed up on carefully. To date, there are many clinical, his- topathological, radiological, and optical techniques to diagnose or capture precancerous and oral cancer lesions early. The routine management of oral cancers is firstly surgical resection with or without postoperative adjuncts and other therapies such as the use of postoperative chemoradiation and radiation. Successful treatment of oral cancer patients is a complex issue that requires a multidisciplinary approach, including oral and maxillofacial surgeons, oral and maxillofacial radiologists, ENT specialists, medical and radio- logical oncologists, prosthodontists, dentists, speech therapists, supportive care experts, and also pathologists or, if possible, maxillofacial","PeriodicalId":426400,"journal":{"name":"Prevention, Detection and Management of Oral Cancer","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129656561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

The Impact of Sequencing Human Genome on Drug Design to Treat Oral Cancer 人类基因组测序对口腔癌药物设计的影响

Prevention, Detection and Management of Oral Cancer Pub Date : 2018-11-05 DOI: 10.5772/INTECHOPEN.80231

Abdul Hameed Khan

{"title":"The Impact of Sequencing Human Genome on Drug Design to Treat Oral Cancer","authors":"Abdul Hameed Khan","doi":"10.5772/INTECHOPEN.80231","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.80231","url":null,"abstract":"Of all the known cancers, oral cancer is the most preventable and it is the second most deadly cancer after the breast cancer. Out of 609,640 deaths of overall cancers, 13,500 died of oral cancer. In spite of this enormous increase in loss of life, there are no useful drugs to treat oral cancer. Sequencing human genome identifies with precision and accuracy the specific mutations responsible for causing oral cancer. In this chapter, a novel approach to design drugs to attack mutated genes in squamous cell carcinoma responsible for caus ing oral cancer is proposed. Alkylating aziridines attack single-stranded DNA shutting off genes. Using dinitrobenzamide dye as a carrier for aziridine, we successfully made a novel class of drugs (CB 1954) which shuts off gene of a solid tumor, Walker Carcinoma 256, in rats. We translated the animal work in humans by using quinone as a carrier for aziridines making AZQ (US Patent 4,146,622) for attacking glioblastoma for treating brain cancer in humans. We propose to search for a carrier for aziridines to attack squamous cell carcinomas to treat oral cancer. Ethical issues are discussed. Since tobacco smoking causes oral cancer, it is the most preventable disease.","PeriodicalId":426400,"journal":{"name":"Prevention, Detection and Management of Oral Cancer","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130902282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2