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B20. THE ONLY CONSTANT IS CHANGE: NEW INSIGHTS INTO AIRWAY REMODELING最新文献

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Senescence Induction in Aging Asthmatic Airway Cells 衰老哮喘气道细胞的衰老诱导
B20. THE ONLY CONSTANT IS CHANGE: NEW INSIGHTS INTO AIRWAY REMODELING Pub Date : 2023-05-01 DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a2807
A. Aghali, L. Khalfaoui, C. Pabelick, J. Passos, Y. Prakash
{"title":"Senescence Induction in Aging Asthmatic Airway Cells","authors":"A. Aghali, L. Khalfaoui, C. Pabelick, J. Passos, Y. Prakash","doi":"10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a2807","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a2807","url":null,"abstract":"","PeriodicalId":425387,"journal":{"name":"B20. THE ONLY CONSTANT IS CHANGE: NEW INSIGHTS INTO AIRWAY REMODELING","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130202843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Oxidized Phosphatidylcholine Promotes Protein Kinase C-mediated B2 Adrenoceptor Dysfunction to Induce Bronchodilator Insensitivity 氧化磷脂酰胆碱促进蛋白激酶c介导的B2肾上腺素能受体功能障碍诱导支气管扩张剂不敏感
B20. THE ONLY CONSTANT IS CHANGE: NEW INSIGHTS INTO AIRWAY REMODELING Pub Date : 2023-05-01 DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a2805
J. Vaghasiya, A. Bagan, A. Dalvand, A. Duaqui, D. Pandey, A. Sikarwar, S. Basu, A. Halayko
{"title":"Oxidized Phosphatidylcholine Promotes Protein Kinase C-mediated B2 Adrenoceptor Dysfunction to Induce Bronchodilator Insensitivity","authors":"J. Vaghasiya, A. Bagan, A. Dalvand, A. Duaqui, D. Pandey, A. Sikarwar, S. Basu, A. Halayko","doi":"10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a2805","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a2805","url":null,"abstract":"","PeriodicalId":425387,"journal":{"name":"B20. THE ONLY CONSTANT IS CHANGE: NEW INSIGHTS INTO AIRWAY REMODELING","volume":"2016 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127397538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Probing Lung Function at High Spatiotemporal Resolution Using a Novel Crystal Ribcage 利用新型晶体胸腔在高时空分辨率下探测肺功能
B20. THE ONLY CONSTANT IS CHANGE: NEW INSIGHTS INTO AIRWAY REMODELING Pub Date : 2023-05-01 DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a2813
H. Nia, R. Banerji, G. Grifno, L. Shi, D. Smoleń, R. LeBourdais, J. Muhvich, C. Eberman, B.E. Hiller, J. Lee, K. Regan, S. Zheng, S. Zhang, J. Jiang, R. Pihl, K. Traber, G. Ligresti, J. Mizgerd, B. Suki
{"title":"Probing Lung Function at High Spatiotemporal Resolution Using a Novel Crystal Ribcage","authors":"H. Nia, R. Banerji, G. Grifno, L. Shi, D. Smoleń, R. LeBourdais, J. Muhvich, C. Eberman, B.E. Hiller, J. Lee, K. Regan, S. Zheng, S. Zhang, J. Jiang, R. Pihl, K. Traber, G. Ligresti, J. Mizgerd, B. Suki","doi":"10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a2813","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a2813","url":null,"abstract":": Real-time, cellular resolution imaging is essential for probing the highly dynamic functions of the lung at the interface of physics, biology, and immunology. CT and MRI modalities have low spatial resolution, and histological approaches provide only snapshots of fixed lungs with little temporal information. Existing intravital imaging approaches cannot include and manipulate the physical and spatiotemporal changes involved in respiratory function. Here, we describe the development of a platform, termed “Lung E x”, to visualize and mechanistically probe the dynamics of a functioning lung at optical resolutions. Lung E x is equipped with a novel transparent ribcage, termed “crystal” ribcage, that provides physiological conditions for a functioning lung and allows high-resolution and real-time optical imaging of nearly the entire lung surface. This imaging capability is obtained while Lung E x preserves the complex 3-D architecture, cellular diversity, and integrative function of the ex vivo ventilated and perfused lung at near in vivo conditions. Utilizing Lung E x in health and key lung diseases such as metastasis, pneumonia, and fibrosis, we probed a wide range of lung dynamic functions and remodeling at multiple spatial scales including alveolar deformation and elasticity, circulation-respiration coupling at the capillary level, cellular deformation, immune cell motility, and vascular transport. By modulating the biophysical environment of Lung E x, we discovered that intravascular","PeriodicalId":425387,"journal":{"name":"B20. THE ONLY CONSTANT IS CHANGE: NEW INSIGHTS INTO AIRWAY REMODELING","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114725996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Hyperoxia Induces Senescence in Developing Human Airway Smooth Muscle Cells 高氧诱导人气道平滑肌细胞衰老
B20. THE ONLY CONSTANT IS CHANGE: NEW INSIGHTS INTO AIRWAY REMODELING Pub Date : 2023-05-01 DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a2808
A. Aghali, M. Koloko Ngassie, B. Roos, A. Koenig-Kappes, J. Teske, C. Klapperich, C. Pabelick, Y. Prakash
{"title":"Hyperoxia Induces Senescence in Developing Human Airway Smooth Muscle Cells","authors":"A. Aghali, M. Koloko Ngassie, B. Roos, A. Koenig-Kappes, J. Teske, C. Klapperich, C. Pabelick, Y. Prakash","doi":"10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a2808","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a2808","url":null,"abstract":"","PeriodicalId":425387,"journal":{"name":"B20. THE ONLY CONSTANT IS CHANGE: NEW INSIGHTS INTO AIRWAY REMODELING","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121893785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recruited Lung Macrophages Contribute to Airway Remodeling and Airway Hyperresponsiveness in a Mouse Model of Severe Allergic Airway Inflammation 在严重过敏性气道炎症小鼠模型中，募集的肺巨噬细胞参与气道重塑和气道高反应性
B20. THE ONLY CONSTANT IS CHANGE: NEW INSIGHTS INTO AIRWAY REMODELING Pub Date : 2023-05-01 DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a2806
B. W. Lewis, M. L. Ford, J. Walum, M. Grayson, M. Ballinger, J. Christman, R. D. Britt
{"title":"Recruited Lung Macrophages Contribute to Airway Remodeling and Airway Hyperresponsiveness in a Mouse Model of Severe Allergic Airway Inflammation","authors":"B. W. Lewis, M. L. Ford, J. Walum, M. Grayson, M. Ballinger, J. Christman, R. D. Britt","doi":"10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a2806","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a2806","url":null,"abstract":"","PeriodicalId":425387,"journal":{"name":"B20. THE ONLY CONSTANT IS CHANGE: NEW INSIGHTS INTO AIRWAY REMODELING","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128634536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CD38 Promotes Th17 Inflammation in Aged Mice With Severe Allergic Airway Inflammation CD38促进重度变应性气道炎症老年小鼠Th17炎症
B20. THE ONLY CONSTANT IS CHANGE: NEW INSIGHTS INTO AIRWAY REMODELING Pub Date : 2023-05-01 DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a2810
M. L. Ford, B. W. Lewis, K. Heyob, T. Harshman, M. Guerau-de-Arellano, R. D. Britt
{"title":"CD38 Promotes Th17 Inflammation in Aged Mice With Severe Allergic Airway Inflammation","authors":"M. L. Ford, B. W. Lewis, K. Heyob, T. Harshman, M. Guerau-de-Arellano, R. D. Britt","doi":"10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a2810","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a2810","url":null,"abstract":"","PeriodicalId":425387,"journal":{"name":"B20. THE ONLY CONSTANT IS CHANGE: NEW INSIGHTS INTO AIRWAY REMODELING","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134408519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of Airway Sensory Hyperinnervation and Reflex Hyperresponsiveness in Offspring of Obese Mothers 肥胖母亲后代气道感觉神经支配和反射性高反应性的发展
B20. THE ONLY CONSTANT IS CHANGE: NEW INSIGHTS INTO AIRWAY REMODELING Pub Date : 2023-05-01 DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a2804
K. Williams, G. Calco, Y. Alharithi, A. Fryer, D. Jacoby, A. Maloyan, Z. Nie
{"title":"Development of Airway Sensory Hyperinnervation and Reflex Hyperresponsiveness in Offspring of Obese Mothers","authors":"K. Williams, G. Calco, Y. Alharithi, A. Fryer, D. Jacoby, A. Maloyan, Z. Nie","doi":"10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a2804","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a2804","url":null,"abstract":"","PeriodicalId":425387,"journal":{"name":"B20. THE ONLY CONSTANT IS CHANGE: NEW INSIGHTS INTO AIRWAY REMODELING","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115306416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Defining the Prostanoid Component in Mast Cell-dependent Constriction of Isolated Human Small Airways 确定离体人小气道肥大细胞依赖性收缩中的前列腺素成分
B20. THE ONLY CONSTANT IS CHANGE: NEW INSIGHTS INTO AIRWAY REMODELING Pub Date : 2023-05-01 DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a2809
J. Säfholm, Sven-Erik Dahlén, Mikael Adner
{"title":"Defining the Prostanoid Component in Mast Cell-dependent Constriction of Isolated Human Small Airways","authors":"J. Säfholm, Sven-Erik Dahlén, Mikael Adner","doi":"10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a2809","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a2809","url":null,"abstract":"","PeriodicalId":425387,"journal":{"name":"B20. THE ONLY CONSTANT IS CHANGE: NEW INSIGHTS INTO AIRWAY REMODELING","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125326482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Opto-Electrical Quantification of Airway Epithelial Injury 气道上皮损伤的光电量化
B20. THE ONLY CONSTANT IS CHANGE: NEW INSIGHTS INTO AIRWAY REMODELING Pub Date : 2023-05-01 DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a2812
J. Kim, J. Chen, S. M. Mir, M. Hudock, M. Pinezich, P. Chen, A. Patel, M. Bacchetta, G. Vunjak‐Novakovic
{"title":"Opto-Electrical Quantification of Airway Epithelial Injury","authors":"J. Kim, J. Chen, S. M. Mir, M. Hudock, M. Pinezich, P. Chen, A. Patel, M. Bacchetta, G. Vunjak‐Novakovic","doi":"10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a2812","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a2812","url":null,"abstract":"","PeriodicalId":425387,"journal":{"name":"B20. THE ONLY CONSTANT IS CHANGE: NEW INSIGHTS INTO AIRWAY REMODELING","volume":"64 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132749876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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