{"title":"Serum Hepcidin Hormone Level and Its Genes Polymorphism","authors":"S. A. Faraj, Naeem Mohammed Mohsen Al-Abedy","doi":"10.5772/INTECHOPEN.93622","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.93622","url":null,"abstract":"This chapter sheds light on hepcidin, historical view of hepcidin, and the time of its discovery in the first section. Then this chapter gives information about the genetic aspect and the importance of gene knowledge of hepcidin in explaining many disorders in human beings, supported by illustration figures. The regulation of iron in the human body as an essential function of hepcidin is discussed in this chapter. Examples of the genes of hepcidin (HAMP and HFE) are highlighted in detail as they are essential in regulating iron as well as discussing the genetic mutations that occur in these genes and their medical and clinical impacts for many diseases such as thalassemia. Finally, the inherited disorders related to hepcidin that lead to genetic diseases are discussed.","PeriodicalId":423099,"journal":{"name":"Genetic Variation","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130221362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Sensitiveness of Expected Heterozygosity and Allelic Richness Estimates for Analyzing Population Genetic Diversity","authors":"M. Barrandeguy, M. V. García","doi":"10.5772/INTECHOPEN.95585","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.95585","url":null,"abstract":"Genetic diversity comprises the total of genetic variability contained in a population and it represents the fundamental component of changes since it determines the microevolutionary potential of populations. There are several measures for quantifying the genetic diversity, most notably measures based on heterozygosity and measures based on allelic richness, i.e. the expected number of alleles in populations of same size. These measures differ in their theoretical background and, in consequence, they differ in their ecological and evolutionary interpretations. Therefore, in the present chapter these measures of genetic diversity were jointly analyzed, highlighting the changes expected as consequence of gene flow and genetic drift. To develop this analysis, computational simulations of extreme scenarios combining changes in the levels of gene flow and population size were performed.","PeriodicalId":423099,"journal":{"name":"Genetic Variation","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131221809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J. L. Ferreira, E. T. Caixeta, F. F. Caniato, T. Setotaw, G. C. Sant’ana, L. M. Ferreira
{"title":"Genetic Diversity of Coffea arabica","authors":"J. L. Ferreira, E. T. Caixeta, F. F. Caniato, T. Setotaw, G. C. Sant’ana, L. M. Ferreira","doi":"10.5772/intechopen.94744","DOIUrl":"https://doi.org/10.5772/intechopen.94744","url":null,"abstract":"Coffea arabica L. is a native coffee species probably originated in Abyssinia, now Ethiopia. The genetic diversity of C. arabica has economic implications directly related to profits by breeding for developing new varieties to a global market. The economic value of C. arabica genetic resources are estimated at US$ 420 million, considered a 10% discount rate. Understanding the extent of traits variability and genetic diversity is essential to guide crosses between genotypes, targeting the development of new varieties with high economic value. This chapter will present the C. arabica economic importance, primarily to Brazil, the most significant world producer; we will outline the origin and dispersion of arabica coffee and briefly show the leading germplasm banks. We will also point out contribution of genetic diversity studies based on morphological, agronomic traits, and molecular markers supporting the development of new varieties. Finally, we present an outline for the future.","PeriodicalId":423099,"journal":{"name":"Genetic Variation","volume":" 2","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"113949728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gilberto Manzo-Sánchez, M. Buenrostro-Nava, Carlos L. Leopardi, M. Orozco-Santos, Mauricio Guzmán-Quesada
{"title":"Genetic Diversity of Fusarium Wilt Disease of Banana","authors":"Gilberto Manzo-Sánchez, M. Buenrostro-Nava, Carlos L. Leopardi, M. Orozco-Santos, Mauricio Guzmán-Quesada","doi":"10.5772/intechopen.94158","DOIUrl":"https://doi.org/10.5772/intechopen.94158","url":null,"abstract":"Bananas and plantains (Musa spp.) represent the fourth most important crop in the world. In 2017, an area of 5,637,508 hectares and a production of 153 million tons were reported. Fusarium wilt caused by the fungus Fusarium oxysporum f. sp. cubense (Foc), is considered one of the most destructive diseases of bananas and plantains worldwide. The pathogen Foc causes a typical wilt syndrome on infected plants, it has a saprophytic and parasitic phase in its life cycle. Fusarium wilt is a “polycyclic” disease. This pathogen shows a relatively diverse population genetic structure for a fungus apparently of asexual reproduction and is composed of different evolutionary lineages, which has 24 groups of vegetative compatibility (VCGs), two clades and nine clonal linage. Foc is a genetically diverse pathogen, although the available evidence so far indicates that it does not use the mechanisms of sexual reproduction, such as recombination, to increase its genetic diversity. Furthermore, the population of this fungus in Southeast Asia shows a high degree of variation, suggesting that Foc lineages evolved together with their hosts in Southeast Asia. Alternatively, it has been suggested that Foc has multiple independent evolutionary origins, both within and outside of the Musaceae origin center.","PeriodicalId":423099,"journal":{"name":"Genetic Variation","volume":"113 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123360700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Potential of Mutation Breeding to Sustain Food Security","authors":"A. Mir, M. Maria, S. Muhammad, S. Ali","doi":"10.5772/intechopen.94087","DOIUrl":"https://doi.org/10.5772/intechopen.94087","url":null,"abstract":"Mutation is a sudden heritable change in the genetic material of living organism. Spontaneous mutation, the natural process that develops new allele copies of a gene was the only source of genetic diversity until the 20th century. Besides, mutations can also be induced artificially using physical or chemical mutagens. Chemical mutations received popularity due to its efficiency in creating gene mutations contrary to chromosomal changes. Mutation has played a vital role in the improvement of crop productivity and quality, resultantly > 3,000 varieties of 175 plant species have been developed either through direct or indirect induced mutation breeding approaches worldwide. The advances in plant breeding also achieved through molecular marker technology. The in vitro mutagenesis, heavy-ion beam, and space mutation breeding are being efficiently used to create genetic variability to improve various complicated traits in crop plants. In mutation breeding, TILLING (Targeting Induced Local Lesions in Genomes), a more advanced molecular technique is being used to identify specific sequential genomic changes in mutant plants. Therefore, the mutation breeding in combination with molecular techniques could be an efficient tool in plant breeding programs. This chapter will discuss and review the mutation breeding application for the improvement of crop productivity and environmental stresses.","PeriodicalId":423099,"journal":{"name":"Genetic Variation","volume":"176 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115901009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Metagenomics and Pandemic Viruses","authors":"P. V. Simas, C. Arns","doi":"10.5772/INTECHOPEN.93687","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.93687","url":null,"abstract":"Humanity’s history contains many pandemic reports and now the scientific community has the possibility to identify the pathogens before the disease emergency. In this perspective, it is essential to carry out large-scale epidemiological studies in key animals that are in constant contact with humans. For this, the next generation sequencing (NGS) by the metagenomic approach—genetic material recovered directly from samples without previous amplification—is able to reveal the hidden microbial diversity. Metagenomes’ work aims to contribute to the facilitation of epidemiological studies through the adoption of simple effective strategies for the pathogens’ identification, understanding the evolutionary dynamic of them before the pandemic time. Here, we have presented some examples related to the successful metagenomic approaches and the continuous advice of the researchers to identify viruses and other possible pandemic pathogens.","PeriodicalId":423099,"journal":{"name":"Genetic Variation","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117017519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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