Squamous Cell Carcinoma - Hallmark and Treatment Modalities最新文献

Comprehensive Molecular Characterization of Squamous Cell Carcinomas 鳞状细胞癌的综合分子特征

Squamous Cell Carcinoma - Hallmark and Treatment Modalities Pub Date : 2019-06-07 DOI: 10.5772/INTECHOPEN.85988

C. Lorz, C. Segrelles, Ricardo Errazquin, R. García-Escudero

引用次数: 2

Molecular Pathogenesis of Oral Squamous Cell Carcinoma 口腔鳞状细胞癌的分子发病机制

Squamous Cell Carcinoma - Hallmark and Treatment Modalities Pub Date : 2019-05-31 DOI: 10.5772/INTECHOPEN.85650

A. Jain

引用次数: 19

Mechanical Force and Actin Dynamics during Cutaneous Squamous Cell Carcinoma (cSCC) Progression: Opportunities for Novel Treatment Modalities 皮肤鳞状细胞癌(cSCC)进展过程中的机械力和肌动蛋白动力学:新治疗方式的机会

Squamous Cell Carcinoma - Hallmark and Treatment Modalities Pub Date : 2019-04-16 DOI: 10.5772/INTECHOPEN.86041

S. Boyle, Z. Kopecki

{"title":"Mechanical Force and Actin Dynamics during Cutaneous Squamous Cell Carcinoma (cSCC) Progression: Opportunities for Novel Treatment Modalities","authors":"S. Boyle, Z. Kopecki","doi":"10.5772/INTECHOPEN.86041","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.86041","url":null,"abstract":"Cutaneous squamous cell carcinoma (cSCC) accounts for 25% of cutaneous malignancies diagnosed in the Caucasian population. Surgical removal in combination with radio- and chemotherapy is an effective treatment; however, prognosis for patients suffering from aggressive cSCC is still relatively poor. Increasing prevalence coupled with high mortality and morbidity in aggressive metastatic forms of cSCC highlights the need for development of novel targeted therapeutics. Metastasis is a complex process requiring dramatic reorganization of the cell cytoskeleton. Recent studies have highlighted the importance of mechanical forces and actin dynamics in cancer cells’ intrinsic ability to invade adjacent tissues, intravasate into vasculature, and ultimately metastasize. Tight regulation of the biochemical and mechanical properties of the actin cytoskeleton drives cellular processes involved in cSCC progression including polarity establishment, morphogenesis, and motility. Here we will provide a short introduction to disease pathogenesis, give an overview of the role of key regulatory proteins governing the mechanical forces and actin dynamics critical to cSCC progression, and describe the contribution of actin remodeling and actomyosin signaling to cSCC progression. We will also discuss how targeting protein regulating mechanical force and actin dynamics may have clinical utility in development of novel treatment modalities for patients suffering from aggressive cSCC.","PeriodicalId":416359,"journal":{"name":"Squamous Cell Carcinoma - Hallmark and Treatment Modalities","volume":"354 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115925598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Evolving Concepts toward Individualized Treatment of Squamous Cell Carcinoma of the Anus 肛门鳞状细胞癌个体化治疗观念的演变

Squamous Cell Carcinoma - Hallmark and Treatment Modalities Pub Date : 2019-03-25 DOI: 10.5772/INTECHOPEN.85545

L. Dewit, A. Cats, G. Beets

{"title":"Evolving Concepts toward Individualized Treatment of Squamous Cell Carcinoma of the Anus","authors":"L. Dewit, A. Cats, G. Beets","doi":"10.5772/INTECHOPEN.85545","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.85545","url":null,"abstract":"Treatment of squamous cell carcinoma of the anus has evolved over the last 5 decades from radical surgery to combined chemoradiation therapy. Radiation treatment techniques have dramatically improved with the development of more powerful computers, algorithms and treatment machines. The clinical impact of the modern radiation treatment techniques, such as intensity-modulated radiotherapy and volumetric modulated arc therapy, is discussed. The standard-of-care regimen still is concurrent Mitomycin C, 5-fluorouracil and high-dose radiation, as was conceived 45 years ago. Variants of this schedule are discussed in this chapter. International guidelines have been generated and implemented. Whereas concurrent chemoradiation therapy is the treatment of choice for locally advanced tumors, early tumors are probably adequately controlled with either reduced dose chemoradiation therapy or radiation therapy alone. Prognostic factors, such as high-risk human papillomavirus, epidermal growth factor receptor and immune response, will be highlighted. The role of surgery in primary care is limited to local excision of T1N0 tumors ≤ 1 cm of the anal margin. Salvage radical surgery is limited to locoregional recurrent, non-metastasized and resectable tumors after chemoradiation therapy. In addition, new treatment modalities, such as targeted therapy and immunotherapy, will be discussed. Current research aims at refining prognostic subgroups to further individualize treatment strategy, implementing quality assurance protocols in international trials and investigating the molecular profile of squamous cell carcinoma of the anus, in order to identify new treatment avenues. This will hopefully change the landscape of anal cancer treatment in the future.","PeriodicalId":416359,"journal":{"name":"Squamous Cell Carcinoma - Hallmark and Treatment Modalities","volume":"50 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127276621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0