Journal of Cancer science and Clinical Oncology最新文献

Degree of Malignancy of T-Cell Acute Lymphocytic Leukemia Related to Autofluorescence in an EL4-Based Model 基于el4的模型中与自身荧光相关的t细胞急性淋巴细胞白血病恶性程度

Journal of Cancer science and Clinical Oncology Pub Date : 2018-07-01 DOI: 10.15744/2394-6520.5.105

Z. Du, Lixia Wang, Yongguang Yang, Yanping Yang

{"title":"Degree of Malignancy of T-Cell Acute Lymphocytic Leukemia Related to Autofluorescence in an EL4-Based Model","authors":"Z. Du, Lixia Wang, Yongguang Yang, Yanping Yang","doi":"10.15744/2394-6520.5.105","DOIUrl":"https://doi.org/10.15744/2394-6520.5.105","url":null,"abstract":"T cell acute lymphocytic leukemia (T-ALL) is an aggressive hematologic malignancy in terms of its pathology and populations. It is important to understand the phenomenon of autofluorescence in living cells because normal and cancer cells can be distinguished by this feature. However, the autofluorescence link to T-ALL is poorly understood. We provide direct evidence that EL4-based T-ALL model expresses both high autofluorescence (FL1+) and low autofluorescence (FL1-) in the current study. The FL1+ phenotype is not as stable as the FL1-phenotype. Interestingly, CD25+ cells of FL1+ can transform to CD25+ cells when injected into mice. Autofluorescence associated with differential expression of CD25 is related to the malignant degree of disease, which is presented by the tissue infiltration and growth speed of EL4 cells. Of note, the phenotypes of autofluorescence and CD25 expression of EL4 cells are related to the sensitivity to NK cells killing and the survival time of EL4-treated leukemic mice in vivo. Thus, autofluorescence monitoring might provide as new insight for investigating the malignant degree and prognosis index of T-ALL.","PeriodicalId":415546,"journal":{"name":"Journal of Cancer science and Clinical Oncology","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125997080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Screening & Awareness of Breast Cancer in an Urban Slum of Pakistan: A Pilot Study 巴基斯坦城市贫民窟乳腺癌的筛查和认识:一项试点研究

Journal of Cancer science and Clinical Oncology Pub Date : 2018-07-01 DOI: 10.15744/2394-6520.5.103

Muhammad F. Iqbal, K. Ma, U. Rabbani, S. Zafar

引用次数: 4

Clinical Significance of microRNA Polymorphisms and Expression Profiles in Oral Cancer Development 口腔癌发生过程中microRNA多态性及表达谱的临床意义

Journal of Cancer science and Clinical Oncology Pub Date : 2018-07-01 DOI: 10.15744/2394-6520.5.104

K. Jamil

引用次数: 0

Trends in Thyroid Malignancies in Accra Ghana: A Retrospective Histopathological Review in the Department of Pathology (1994-2013), Korle-Bu Teaching Hospital 加纳阿克拉甲状腺恶性肿瘤的趋势:Korle-Bu教学医院病理科(1994-2013)的回顾性组织病理学回顾

Journal of Cancer science and Clinical Oncology Pub Date : 2018-07-01 DOI: 10.15744/2394-6520.5.101

Der Em, Y. Tettey, Gyasi Rk, E. Wiredu

引用次数: 2

Compartmentalization Modules of Inflammatory Response are Centered on the Epithelial-Mesenchymal Transition of Transforming Cells in Carcinogenesis 炎症反应的区隔化模块集中于癌变过程中转化细胞的上皮-间质转化

Journal of Cancer science and Clinical Oncology Pub Date : 2018-07-01 DOI: 10.15744/2394-6520.5.102

Agius Lm

{"title":"Compartmentalization Modules of Inflammatory Response are Centered on the Epithelial-Mesenchymal Transition of Transforming Cells in Carcinogenesis","authors":"Agius Lm","doi":"10.15744/2394-6520.5.102","DOIUrl":"https://doi.org/10.15744/2394-6520.5.102","url":null,"abstract":"The epithelial-mesenchymal transition (EMT) event in carcinogenesis is dependent on multiple operant pathways of master transcription as proposed for NF-kappaB and in terms of the initiated progression of malignant transformation. Inflammation is a primarily compartmentalized series of distinct and overlapping systems that induce and enhance multifocal operabilities within both the nucleus and cytoplasm by systems of enhancer/inhibitory modes of modulation of multi-gene transcription. In terms therefore of a compensatory system of response, carcinogenesis includes a series of steps in characterization of nuclear/cytoplasmic duality targeting ultimately the emergence of tumor cell invasiveness as the epithelial-mesenchymal transition. Emergence of such transition is hallmark for carcinogenesis within contexts of aberrant cell proliferation and anti-apoptosis as exerted by NF-kappaB proinflammation. NF-kB is the main transcription factor that regulates the expression of inflammation-related genes and is in turn influenced by autophagy; also autophagy interacts with inflammation in numerous disease states. It is relevant; in addition, that NF-kB participates in the release of inflammatory cytokines in patients with sepsis with pathogenic implications of sepsis in carcinogenesis.","PeriodicalId":415546,"journal":{"name":"Journal of Cancer science and Clinical Oncology","volume":"209 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114221662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0