SOJ Diabetes and Endocrinology Care最新文献

{"title":"Weight Loss Ameliorates Markers of Systemic Inflammation and Endothelial Dysfunction in Obstructive Sleep Apnea Obese Patients","authors":"S. El-Kader","doi":"10.53902/sojdec.2021.01.000505","DOIUrl":"https://doi.org/10.53902/sojdec.2021.01.000505","url":null,"abstract":"Background: Obstructive sleep apnea (OSA) is the most common sleep disorder in clinical practice. Its growing worldwide prevalence may be due to the rising incidence of obesity in the public. OSA has been increasingly recognized as a major public health issue, as it has a significant influence on the incidence and prognosis of cardiovascular diseases. Although, these abnormalities could be modulated with weight reduction, there is limitation in clinical studies have addressed the beneficial effects of weight reduction in modulating biomarkers of endothelial dysfunction and cytokines for obesity associated with OSA. Objective: This study was designed to detect the effects of weight loss on the inflammatory cytokines and adhesive molecules in obese patients with obstructive sleep apnea. Methods: Seventy obese patients with moderate to severe OSA (the apnea-hypopnea index (AHI)>15 events/hour), their age ranged from 36- 50 years and their body mass index ranged from 26-31kg/m2 were equally assigned into two groups: the weight reduction group received aerobic exercises, diet regimen, where the control group received no intervention for 12 weeks. Results: The mean values of body mass index (BMI), apnea-hypopnea index (AHI), tumor necrosis factor –alpha (TNF-α), interleukin-6 (IL-6), C-reactive protein (CRP), inter-cellular adhesion molecule (ICAM-1), vascular cell adhesion molecule (VCAM-1) and E-selectin were significantly decreased in the training group, however the results of the control group were not significant. In addition, there were significant differences between both groups at the end of the study. Conclusion: Weight loss ameliorates inflammatory cytokines and adhesive molecules among obese patients with obstructive sleep apnea.","PeriodicalId":410092,"journal":{"name":"SOJ Diabetes and Endocrinology Care","volume":"10 1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116755875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Malignancy in a Family with Carney’s Complex","authors":"Sean Roy Beh","doi":"10.53902/sojdec.2021.01.000501","DOIUrl":"https://doi.org/10.53902/sojdec.2021.01.000501","url":null,"abstract":"Carney Complex is a genetic disease characterized by skin lentigenes and freckling and the growth of benign tumors in endocrine glands as well as cardiac myxoma. Malignant tumors in Carney’s Complex are extremely rare with few other case reports. We report the rare occurrence of ovarian malignancy and thyroid carcinoma separately in 2 out of 3 family members diagnosed with Carney Complex.","PeriodicalId":410092,"journal":{"name":"SOJ Diabetes and Endocrinology Care","volume":"57 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130174908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolic Risk Markers in Insulin Resistance and Non-Insulin Resistance Type 2 Diabetes Mellitus","authors":"Thae Nu Htwe","doi":"10.53902/sojdec.2021.01.000508","DOIUrl":"https://doi.org/10.53902/sojdec.2021.01.000508","url":null,"abstract":"","PeriodicalId":410092,"journal":{"name":"SOJ Diabetes and Endocrinology Care","volume":"173 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132324133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of Labor and Psychiatricpostpartum Diseases Using Potential Anti-obesity and Antidiabetic Plants in Cameroon","authors":"T. Nolé","doi":"10.53902/sojdec.2021.01.000509","DOIUrl":"https://doi.org/10.53902/sojdec.2021.01.000509","url":null,"abstract":"Globally more than 550 women die per year from childbirth-related causes. Around 9% of women suffer from postpartum post-traumatic stress disorder after childbirth. Postpartum bipolar disorder is humor episodes such as mania, hypomania or depression, which start throughout pregnancy or in few weeks after child bearing. Fifty percent (50%) worldwide estimation of motherly deaths arise in sub-Saharan Africa region alone. Depression is a devastating temperament and mental sickness touching around 13% of postpartum mothers worldwide. The occurrence of 25%-60% of depression is typical of low- and middle-income countries. A combined prevalence of 14.4% of teenage deliveries was revealed in Cameroon where there is unsatisfactory information on the risk factors of motherly mortality and mother care after childbirth. In hinterland local therapists especially in Bororo and Pygmies communities, have developed indigenous strategies in the treatment of certain cases of abnormal labor and psychiatric postpartum sicknesses. Accordingly this study aimed to identify principally amongst anti-obesity and antidiabetic plants used in Cameroon, those with efficient effect on labor and psychiatric mother care after delivery. To achieve this objective the search strategy was performed to identification these plants using the following research engines in Google, Google Scholar and PubMed: 1) Properties oxytocic of a given diabetic or anti-obesity plant name 2) A given diabetic or anti-obesity plant name with capacity to control labor 3) Anti-psychiatric postpartum disease properties of a given diabetic or anti-obesity plant name. Twenty plants used in the treatment of difficult labor and psychiatric postpartum treatment in Cameroon were recorded. Only Daturastramonium and Amblygonocarpusandongensis were respectively poisonous and slightly toxic. Mucunapruriens, Peperomiapellucida, Momordicacharantia and Xylopiaaethiopica are more effective. Nevertheless, preventive measures such as selection of safe herbal medications, avoid psychiatric postpartum diseases symptoms, adequate dosages and their stabilization, duration of treatment, good sanitary herbal medicines preparation, and conservation, must be determined and rigorously respected.","PeriodicalId":410092,"journal":{"name":"SOJ Diabetes and Endocrinology Care","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127821134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Adrenergic Drugs on the Lipopolysaccharide-Induced Oxidative Stress and Liver Damage in the Rat","authors":"O. M. Salam","doi":"10.53902/sojdec.2021.01.000507","DOIUrl":"https://doi.org/10.53902/sojdec.2021.01.000507","url":null,"abstract":"Aim: We aimed to investigate the effect of the adrenergic system on oxidative stress and liver damage during mild systemic inflammation in rats. Methods: For this purpose, Eschrechia coli lipopolysacchride (LPS; 300μg/kg) was intraperitoneally injected either alone or along with the α-2 adrenoceptor antagonist yohimbine, the non-selective β adrenoceptor antagonist propranolol, the and β-adrenoceptor agonist adrenaline and rats euthanized 4h later. The effects of these drugs in saline-treated rats were also studied. Serum alanine aminotransferase (ALT), aspartate aminotransferase, and alkaline phosphatase activities were measured. Liver tissue levels of malondialdehyde (MDA), nitric oxide (NO), reduced glutathione (GSH) were determined and liver histology evaluated. Results: In saline-treated rats (i) yohimbine caused significantly increased ALT, AST and ALP in serum. In addition, yohimbine increased MDA, NO and decreased GSH in liver tissue and caused cytoplasmic vacuolations and cellular infiltration: (ii) adrenaline treatment increased serum ALT, AST, liver MDA, decreased liver GSH and caused minute vacuolar degeneration and foci of necrosis; (iii) in contrast, there were no biochemical or histologic alterations after propranolol treatment. In endotoxaemic rats; (i) serum aminotransferases and alkaline phosphatase were significantly increased by yohimbine together with increased liver MDA, NO and decreased GSH content; (ii) serum ALT decreased by propranolol and adrenaline while serum ALP increased by adrenaline; (iii) liver GSH increased by propranolol; (iv) LPS administration caused acute liver damage in the form of foci of necrosis, vacuolar degeneration and aggregates of inflammatory cellular infiltration. Compared with the LPS only group, treatment with yohimbine increased while propranolol or adrenaline produced less liver damage. Conclusions: Thus, blockade of α-2 adrenoceptors increased while β adrenoceptor antagonism decreased oxidative stress and liver damage following LPS administration in rats. Collectively, these results indicate a benefit from blockade of beta-adrenoceptors in protecting the liver during mild systemic inflammation in part by decreasing oxidative stress.","PeriodicalId":410092,"journal":{"name":"SOJ Diabetes and Endocrinology Care","volume":"23 7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116374857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diabetic Emergencies: Experience of a Tertiary Endocrine Center","authors":"Z. Pekkolay","doi":"10.53902/sojdec.2021.01.000503","DOIUrl":"https://doi.org/10.53902/sojdec.2021.01.000503","url":null,"abstract":"Purpose: In this study, we aimed to retrospectively evaluate the demographic data, clinical features, laboratory data, precipitating causes of diabetic emergencies, complications in the follow-up of adult patients who applied to our hospital due to diabetic emergencies. Methods: The study included patients aged 18 years and older referred to a tertiary endocrine center with diabetic ketoacidosis (DKA), hyperosmolar hyperglycemic state (HHS) hypoglycemia between January 2010 and May 2018. Results: The study was carried out with 165patients, 69(41.8%) males, and 96(58.2%) females. The mean age of the patients was 43.8±20.4(18- 88). Of these patients, 77% (n=127) had DKA, 17% (n=28) had HHS and 6% (n=10) had hypoglycemia. Of the patients 55.2% (n=91) were type 1 DM, 44.8% (n=74) were type 2DM. When the precipitating causes of diabetic emergencies were examined, 32.7%(n=54) poor adherence to treatment and 32.1%(n=53) infection of the patients were involved. The new diagnosis was DM in 10.9% of the patients (n=18). The most common complication after treatment was hypopotassemia with 38.7% (n=60), but no complication was observed in the majority of patients (54.8%). In our study, total mortality was 1.8% and 11.1% in HHS patients. No mortality was found in DKA and hypoglycemia patients. Conclusion: Diabetic ketoacidosis is more common in DM patients than in other diabetic emergencies. Approximately 11% of patients do not have a known diagnosis of diabetes. Poor adherence to treatment and infection are the most important precipitating causes of the diabetic emergency. The mortality rate is very low with early diagnosis and correct treatment.","PeriodicalId":410092,"journal":{"name":"SOJ Diabetes and Endocrinology Care","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128265129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resolution of Severe Anorexia Nervosa Associated with Gender Dysphoria (Dysphorexia) by Testosterone Therapy in Two Male Transgender Youth","authors":"Francisco Javier Martinez Martin","doi":"10.53902/sojdec.2021.01.000502","DOIUrl":"https://doi.org/10.53902/sojdec.2021.01.000502","url":null,"abstract":"Anorexia nervosa is a severe and potentially lethal eating disorder. In transgender youth with severe gender dysphoria, a severe eating disorder (proposed name: dysphorexia), coherent with anorexia nervosa may be triggered by the desire to avoid the cisgender pubertal transition. In these patients, gender-affirming hormone therapy can be extremely effective. We report hereby the cases of two female-to-male transsexual patients with severe gender dysphoria whose anorexia nervosa was related to their pubertal development and who promptly recovered when they started gender-affirming hormone therapy with testosterone, after very limited success with standard psychotherapy and pharmacotherapy for anorexia nervosa. Our patients could not access pubertal suppression due to lack of parental consent in one case and failure to express the conflict in the other. We postulate that avoiding the cisgender pubertal transition with GnRH agonist treatment might also be able to prevent the development of dysphorexia.","PeriodicalId":410092,"journal":{"name":"SOJ Diabetes and Endocrinology Care","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116682642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}