TMR Integrative Medicine最新文献

{"title":"Treatment and prevention of diabetes complicated with non-alcoholic fatty liver disease by integrated traditional Chinese and Western medicine","authors":"Xu He, Xiu-Ping Chen, Qi He, Zhong-Fa Wang, Jian-Hua Zhong, Kui Wang","doi":"10.53388/tmrim202307027","DOIUrl":"https://doi.org/10.53388/tmrim202307027","url":null,"abstract":"Today’s social economy and science and technology levels are developing rapidly. Type 2 diabetes mellitus (T2DM) is increasing in incidence, and T2DM promotes non-alcoholic fatty liver disease (NAFLD) through some mechanisms. The pathogenesis of T2DM and NAFLD is interconnected, interacted with, and promoted. While increasing the economic burden on patients, it also affects the quality and life of patients themselves. In the world, the current treatment methods include exercise and diet control, drugs (including sugar reduction, lipid-lowering drugs, etc.), weight loss surgery, etc., but currently, researching drugs can only control the progress of the disease. At present, there is no drug for T2DM combined with NAFLD treatment. Therefore, it is necessary to find and study effective drugs for NAFLD. Based on the principle of “syndrome differentiation,” traditional Chinese medicine (TCM) played an important role in treating this disease. The theory of TCM believes that the cause of NAFLD is mostly diet disorders and imbalances in daily life, leading to liver Qi stagnation, spleen dysfunction, and liver and kidney deficiency, producing phlegm and stasis. During the treatment process, we must pay attention to the goal of phlegm turbidity, but also pay attention to the source of phlegm turbidity, strengthen the spleen and stomach, nourish the liver and kidney, and restore the physiological function of the body. The ingredients of Chinese medicine extracts have the effects of antagonist oxidation stress, protecting liver cells, improving fibrous soluble systems, and promoting lipid metabolism, thereby reducing inflammatory factors to release damage to liver cells. By combining the diagnosis of TCM syndromes with Western medical disease diagnosis, the model of disease diagnosis combined with syndrome differentiation can compensate for some of the limitations of TCM’s sole reliance on syndrome differentiation, allowing for a better grasp of the disease. In treatment, a dual approach using traditional Chinese and Western medicine can enhance efficacy and reduce toxicity, leveraging both complementary strengths. Chinese medicine explains its treatment of NAFLD from a macro and micro level, providing a safer and more effective method for treating the disease.","PeriodicalId":406495,"journal":{"name":"TMR Integrative Medicine","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135754367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of acupuncture to regain consciousness in patients with traumatic brain injury: a systematic review and meta-analysis","authors":"Lamichhane Narendra, Yi-Fan Zhang, Zi-Chen Zhang, Zhi-Fang Xu, Yu Luo, Mei-Dan Zhao, Tian-Yi Zhao","doi":"10.53388/tmrim202307031","DOIUrl":"https://doi.org/10.53388/tmrim202307031","url":null,"abstract":"Background: Traumatic brain injury (TBI) is a leading cause of death and disability worldwide, and consciousness disorder is a common problem in TBI patients. Acupuncture has been used to improve neurological deficits in patients with TBI. This meta-analysis aims to evaluate the effects and safety of acupuncture in improving consciousness in patients with TBI when compared with other therapies. Methods: A systematic search was conducted in electronic databases PubMed, EMBASE, Web of Science, the Cochrane Central Register of Controlled Trials, Allied and Complementary Medicine Database, WHO International Clinical Trials Registry Platform, ClinicalTrials.gov, and Google Scholar for randomized controlled trials that investigated the effect of acupuncture on patients with TBI. From the inception of databases to March 2023. Results: A total of 653 participants were included in nine trials. We found that acupuncture adjunct to routine treatment significantly improved the wakeup rate of patients in TBI when compared with routine treatment alone (relative risk = 1.36, 95% confidence interval: 1.16 to 1.59, I 2 = 4.78%, P = 0). Additionally, we found that acupuncture is significantly associated with reduced impaired consciousness after TBI when adjunct to medicine therapy. As a safe intervention, acupuncture can also improve the activities of daily living for people with TBI (mean difference = 15.71, 95% confidence interval: 9.19 to 22.22, I 2 = 0%, P = 0). Conclusion: Acupuncture can improve consciousness and braise wakeup of patients with TBI when adjunct to conventional treatment compared with routine treatment alone. Further high-quality studies are needed to confirm these findings and to determine the optimal acupuncture treatment parameter for TBI.","PeriodicalId":406495,"journal":{"name":"TMR Integrative Medicine","volume":"157 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135447035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shengmai Yin formula promotes ventricular remodeling in chronic heart failure rats by inhibiting excessive autophagy via activating AKT/mTOR pathway","authors":"Ye Li, Qiang Xu, Wei Zhou, Mei-Juan Lu, Jian-Zhong Pang, Juan Wang, Tian Li, Xiao-Yue Cai, Yan-Kun Liu","doi":"10.53388/tmrim202307029","DOIUrl":"https://doi.org/10.53388/tmrim202307029","url":null,"abstract":"Background: Shengmai Yin (SMY) formula, a traditional Chinese medicine, shows a definite therapeutic effect on chronic heart failure (CHF) in clinical practice, but the molecular mechanism remains largely unknown. The PI3K/Akt/mTOR pathway is a classic pathway of autophagy and plays a pivotal role in the occurrence and development of CHF. Here, we aimed to investigate whether SMY formula treat CHF rats by inhibiting excessive autophagy. Methods: Echocardiography was conducted to evaluate cardiac function. Transmission electron microscopy was used to observe the arrangement of myocardial cells. Enzyme linked immunosorbent assay analysis was performed to quantitative detecting the content of N-terminal pro-B-type natriuretic peptide, stromelysin-2, TNF-α in rat serum. Western blotting was used to detect the expression of AKT, p-AKT, mTOR, p-mTOR, light chain 3 (LC3), and p62. In vitro, myocardial cells were treated with hypoxia reoxygenation and then intervened with SMY. Cell counting kit-8 method was used to measure the cell viability. The immunofluorescence expression of LC3 protein were also examined. Results: In vivo, SMY intervention assisted in the ventricular remodeling, reduced the levels of N-terminal pro-B-type natriuretic peptide, stromelysin-2, TNF-α in serum, and recovered myocardial cell structure in CHF rats. Treatment with SMY significantly promoted the ratio of p-AKT/AKT, p-mTOR/mTOR, and down-regulated the expression level of p62 and the ratio of LC3-II/LC3-I. In vitro, when the concentration of SMY containing serum reached 40% in the medium, the activity of myocardial cells reached the highest at 135.14%. SMY inhibited the expression of LC3 in hypoxic-reoxygenation embryonic ventricular myocytes cells. When the hypoxic reoxygenation cells treated with p-mTOR inhibitor, rapamycin, or p-AKT inhibitor, API-1, SMY could also down-regulated the LC3 expression level. Conclusions: SMY formula functions in restoring cardiac function and promoting myocardial ultrastructural recovery by reducing autophagy activity through up-regulating the ratio of p-AKT/AKT, p-mTOR/ mTOR, and down-regulating the expression level of p62 and the ratio of LC3-II/LC3-I in CHF rats.","PeriodicalId":406495,"journal":{"name":"TMR Integrative Medicine","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136366580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the potential mechanisms of luteolin against ulcerative colitis and colorectal cancer via network pharmacology and molecular docking","authors":"Qiang Zhang, Shuang Liu, Zi-Ye Li, Yu-Jie Shang, Larwubah Kollie, Zong-Suo Liang","doi":"10.53388/tmrim202307026","DOIUrl":"https://doi.org/10.53388/tmrim202307026","url":null,"abstract":"Background : Patients diagnosed with ulcerative colitis (UC) are known to have an increased susceptibility to colorectal cancer (CRC). However, the shared underlying mechanisms between UC and CRC remain unclear. Given the therapeutic potential of luteolin in both UC and CRC, this study aims to elucidate the molecular targets and mechanisms through which luteolin exerts its effects against these diseases. Methods : The GeneCards database, DisGENet database, and Gene Expression Omnibus database were utilized to analyze the targets associated with UC and CRC. Subsequently, the Traditional Chinese Medicine Systems Pharmacology and SwissTargetPrediction databases were employed to identify luteolin-related targets. The identified luteolin-related targets were then mapped to official gene symbols using the UniProt database. The Cytoscape 3.9.0 software was utilized to construct a network of luteolin-associated targets. Venn diagram analysis was performed to identify common targets among UC, CRC, and luteolin. The common targets were further analyzed using the STRING database to construct a protein-protein interaction network. The “cytoHubba” plugin in Cytoscape 3.9.0 was employed to identify hub targets within the PPI network. Gene Ontology functional analysis and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis were conducted on the hub targets. Finally, molecular docking using AutoDock and PyMOL software was performed to assess the binding affinity between luteolin and the hub targets. Results : Luteolin was found to interact with a total of 149 pharmacological targets, while UC and CRC were associated with 1232 and 3278 targets, respectively. Forty-six common targets were identified among luteolin, UC, and CRC. Through the application of seven different algorithms, seven hub targets were identified, TP53, AKT1, TNF, SRC, EGFR, and MMP9. Bioinformatics enrichment analysis revealed 49 enriched pathways through Kyoto Encyclopedia of Genes and Genomes analysis, while Gene Ontology analysis yielded a total of 245 biological processes, 4 cellular components, and 7 molecular functions. Molecular docking simulations demonstrated a good binding affinity between luteolin and the hub targets. Conclusion : This study identified multiple potential pharmacological targets and elucidated various biological pathways through which luteolin may exert its therapeutic effects in the treatment of UC and CRC. These findings provide a solid theoretical foundation for further experimental investigations in the treatment of UC and CRC.","PeriodicalId":406495,"journal":{"name":"TMR Integrative Medicine","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135498122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pulmonary microecology is a key role of traditional Chinese medicine in improving pulmonary fibrosis","authors":"Ze-Hua Wang, Zhi-Feng Xue","doi":"10.53388/tmrim202307028","DOIUrl":"https://doi.org/10.53388/tmrim202307028","url":null,"abstract":"Idiopathic pulmonary fibrosis (IPF) is a type of interstitial lung disease, characterized by an unknown etiology, chronicity, and progressive respiratory impairment. Following IPF diagnosis, patients exhibit a median survival of only 2 to 3 years, with a staggering 70% to 80% mortality rate within 5 years [1]. However, the corresponding therapeutic options remain severely limited. Presently, the efficacious treatment drugs are Pirfenidone and Nintedanib. Regrettably, these two drugs fail to substantially reverse pulmonary fibrosis, offering only a partial slowing of its progression. IPF predominantly afflicts the elderly [1], and with the aging population in China constinuously increasing, there is a compelling need to explore novel and more effective treatment strategies. Interestingly, studies by David N. O’Dwyer and colleagues have demonstrated a significant correlation between pulmonary microbial load and the progression of lung fibrosis in IPF patients, underscoring the intimate connection between pulmonary microbiota and the advancement and prognosis of IPF [2]. In the realm of traditional Chinese medicine, IPF falls within the category of lung impediment and lung flaccidity, yet, a unified diagnostic","PeriodicalId":406495,"journal":{"name":"TMR Integrative Medicine","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136008758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Astragalus polysaccharide on immune function in B16 melanoma mice","authors":"FangHua Wu, Kui Chen, Dekun Zhang, Chao Gong, JiangYue Yu, ShenZhou Huang, ChenXin Huang, Liqun Wang","doi":"10.53388/tmrim202105012","DOIUrl":"https://doi.org/10.53388/tmrim202105012","url":null,"abstract":"","PeriodicalId":406495,"journal":{"name":"TMR Integrative Medicine","volume":"5 0","pages":"e21012-e21012"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147878135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}