Current Concepts in Zika Research最新文献

Neuromuscular Effects and Rehabilitation in Guillain-Barré Syndrome Associated with Zika Virus Infection 与寨卡病毒感染相关的格林-巴罗综合征的神经肌肉效应和康复

Current Concepts in Zika Research Pub Date : 2020-10-27 DOI: 10.5772/intechopen.93930

T. Harbo, H. Andersen

{"title":"Neuromuscular Effects and Rehabilitation in Guillain-Barré Syndrome Associated with Zika Virus Infection","authors":"T. Harbo, H. Andersen","doi":"10.5772/intechopen.93930","DOIUrl":"https://doi.org/10.5772/intechopen.93930","url":null,"abstract":"The 2015–2017 Zika Virus outbreak caused a high increase in patients with Guillain-Barré syndrome (GBS), a post infectious autoimmune disease of the peripheral nerves. The severity of GBS can range from mild impairment with fast recovery to complete paralysis including severe respiratory or autonomic failure. Recovery may take months and even years and may be incomplete despite disease modifying treatment with IVIG or plasma exchange. Therefore, optimal supportive care and effective rehabilitation remain crucial. Multidisciplinary rehabilitation is recommended but may be challenging in the acute phase because of limited patient participation due to profound muscle weakness and severe pain. Inactive denervated muscles will inevitably undergo rapid degeneration resulting in wasting, weakness, and contractures as major long-term complications in severely affected patients. In this chapter, the current evidence of rehabilitation on the short- and long-term motor function in GBS is reviewed, including newly obtained experiences with neuromuscular electrical stimulation (NMES). Rehabilitation remains an area lacking well designed and controlled clinical studies and thus a clear lack of evidence-based guidelines.","PeriodicalId":404523,"journal":{"name":"Current Concepts in Zika Research","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114271963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Guillain-Barre Syndrome and Miller Fisher Variant in Zika Virus Disease 寨卡病毒病的格林-巴利综合征和米勒-费舍尔变异体

Current Concepts in Zika Research Pub Date : 2020-07-14 DOI: 10.5772/intechopen.93128

R. H. Jadah

引用次数: 0

Risk Management of Zika in Context of Medical Provision and in Favor of Disaster Medicine: New Opportunities for Risk Reduction (The Conceptual Idea) 在医疗提供和灾难医学背景下的寨卡风险管理:降低风险的新机会(概念构想)

Current Concepts in Zika Research Pub Date : 2020-05-21 DOI: 10.5772/intechopen.92128

D. Dimitrova

{"title":"Risk Management of Zika in Context of Medical Provision and in Favor of Disaster Medicine: New Opportunities for Risk Reduction (The Conceptual Idea)","authors":"D. Dimitrova","doi":"10.5772/intechopen.92128","DOIUrl":"https://doi.org/10.5772/intechopen.92128","url":null,"abstract":"There is a need for timely medical care to the population for the risk management of Zika nowadays. Although scientists determine the widespread nature of the worldwide outbreak of Zika virus infection, it seems clear that there is a real need for outside help to deal with this disease. The Zika disease affects predominantly negatively the fetus in pregnant women, but cases of severe clinical manifestations are also reported among adults. Irrespective of age, it is known to affect the nervous system in humans. The vector causes epidemiological data to expand its area of expertise. In this light of expression, specialists define and attribute to this disease the type and significance of a worldwide disaster management. This requires an in-depth study and analysis of risk factors and their management as a fundamental approach for their prevention and for the benefit of disaster medicine. Reducing the risk with existing traditional tools and methods is not enough to meet the growing needs of people and territories at risk of Zika infection. New strategy approaches and technologies are being sought, and new risk reduction (RR) options are being interpreted. A framework for an innovative conceptual idea based on nano-biotechnology for risk reduction and prevention for Zika virus infection is presented.","PeriodicalId":404523,"journal":{"name":"Current Concepts in Zika Research","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130628410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Manifestations in Pregnant Women and Congenital Abnormalities in Fetus and Newborns during a Zika Transmission Period in South Mexico 南墨西哥寨卡病毒传播期孕妇临床表现及胎儿和新生儿先天性异常

Current Concepts in Zika Research Pub Date : 2020-03-10 DOI: 10.5772/intechopen.90616

N. Pavía-Ruz, S. Contreras-Capetillo, Yamila Romer, Nina Valadez Gonzalez, H. Gómez-Dantés, G. Vazquez-Prokopec, P. Manrique-Saide

引用次数: 0

Animal Models of Zika Virus Sexual Transmission 寨卡病毒性传播的动物模型

Current Concepts in Zika Research Pub Date : 2020-02-24 DOI: 10.5772/intechopen.91256

R. K. Campos, Erin M. Mcdonald, A. Brault, S. Rossi

{"title":"Animal Models of Zika Virus Sexual Transmission","authors":"R. K. Campos, Erin M. Mcdonald, A. Brault, S. Rossi","doi":"10.5772/intechopen.91256","DOIUrl":"https://doi.org/10.5772/intechopen.91256","url":null,"abstract":"ZIKV was first identified in the 1940s as a mosquito-borne virus; however, sexual transmission, which is uncommon for arboviruses, was demonstrated more than 60 years later. Tissue culture and animal models have allowed scientists to study how this transmission is possible. Immunocompromised mice infected with ZIKV had high viral loads in their testes, and infection of immunocompetent female mice was achieved following intravaginal inoculation or inoculation via mating with an infected male. These mouse studies lead researchers to investigate the individual components of the male reproductive system. In cell culture and mouse models, ZIKV can persist in Sertoli and germ cells of the testes and epithelial cells in the epididymis, which may lead to sexual transmission even after ZIKV has been cleared from other tissues. ZIKV has also been studied in nonhuman primates (NHPs), which appears to mimic the limited human epidemiological data, with low rates of symptomatic individuals and similar clinical signs. Although refinement is needed, these animal models have proven to be key in ZIKV research and continue to help uncovering the mechanisms of sexual transmission. This review will focus on the animal models used to elucidate the mechanisms of sexual transmission and persistence of flaviviruses.","PeriodicalId":404523,"journal":{"name":"Current Concepts in Zika Research","volume":"38 1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125375842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Eye and the Zika Virus 眼睛和寨卡病毒

Current Concepts in Zika Research Pub Date : 2019-10-29 DOI: 10.5772/intechopen.89847

Dayron F. Martínez-Pulgarín, C. M. Córdoba-Ortega, Fabio Daniel Padilla-Pantoja

{"title":"The Eye and the Zika Virus","authors":"Dayron F. Martínez-Pulgarín, C. M. Córdoba-Ortega, Fabio Daniel Padilla-Pantoja","doi":"10.5772/intechopen.89847","DOIUrl":"https://doi.org/10.5772/intechopen.89847","url":null,"abstract":"Ocular involvement in Zika virus (ZIKV) infection can be present both in adults and infants as acquired and congenital diseases respectively. Through experimental studies, there has been clarified important mechanisms of ocular pathogenesis that allow the establishment of potential objectives for antiviral drugs development. The spread of the virus at the ocular level could be hematogenous or axonal, however the hematogenous route through the choroid is suggested as the most important initial mechanism for infection. Ocular manifestations vary according to the age of presentation, being mild and self-limited in adults and potentially devastating in children, related to congenital Zika syndrome (CZS). Ocular diagnosis is made based in clinical features and contact/travel history to countries of epidemiological importance; fundoscopy, optical coherence tomography, fluoresceinic/green indocianine angiography, cultures, serological and molecular tests are useful diagnostic tools. Ocular management is focused according to the clinical context of each patient. Prevention is carried out in a comprehensive manner and further research is directed to vaccine development and specific antiviral treatment. Proper attention requires a multidisciplinary team in order to reach complete visual evaluation and early rehabilitation.","PeriodicalId":404523,"journal":{"name":"Current Concepts in Zika Research","volume":"65 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133972266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1