{"title":"Quality of Life in Neurogenic Bladder Patients and Improvement after Botulinum Toxin Injection","authors":"G. Palleschi, A. Cardi","doi":"10.5772/intechopen.102384","DOIUrl":"https://doi.org/10.5772/intechopen.102384","url":null,"abstract":"Various neurogenic conditions may determine an altered function of the bladder and urethral sphincters leading to urinary symptoms. Among these symptoms, loss of urine is considered the most bothersome, and recent literature has proposed that urinary incontinence and poor quality of life should be considered as associated conditions. Urinary incontinence is responsible for reducing the enjoyment of life, including loss of self-confidence and limitation of social activity; it is also associated with anxiety, depression, and deterioration in sexual life, and reduced physical activity. Conservative treatments represent a first-line therapeutic approach to neurogenic urinary disorders, followed by oral medications. However, these treatments often do not provide complete recovery from symptoms, especially from urinary incontinence. Onabotulimun toxin A has proven to be safe and effective for treating neurogenic urinary incontinence and its use is associated with a strong improvement of patients’ quality of life. Furthermore, this treatment lowers the risk of severe complications to the upper urinary tract, reducing the need for hospitalization. Quality of life improvement as well as clinical efficacy must be considered targets of the therapy, and the use of onabotulimun toxin A for treating neurogenic urinary incontinence reaches both these goals.","PeriodicalId":397025,"journal":{"name":"Botulinum Toxin - Recent Topics and Applications [Working Title]","volume":"143 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122917766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
I. Katbeh, Mohammad Osama Makkeiah, T. Kosyreva, L. Saneeva
{"title":"Gummy Smile and Treatment with Botulinum Toxin Type A (Botox)","authors":"I. Katbeh, Mohammad Osama Makkeiah, T. Kosyreva, L. Saneeva","doi":"10.5772/intechopen.102341","DOIUrl":"https://doi.org/10.5772/intechopen.102341","url":null,"abstract":"A smile plays an important role in determining a person’s initial impression, and its assessment has become integral to clinical evaluation. A smile with an esthetic appearance should be symmetrical and should reveal less than 2 mm of gums when smiling. A gingival smile, gummy smile, or high smile line, is defined as the number of excess gums on the upper jaw exposed. This may have some serious psychological repercussions on the patient, which may sometimes lead them to conceal their smile to avoid “embarrassment.” One of the most common methods of treating a gingival smile resulting from an overactive lip is lip reposition as a surgical procedure and the injection of type A (Botox) toxin as an injectable inhibitor of muscle action. However, many patients refrain from surgical treatment because of fear of complications and pain. In this case, injections of botulinum toxin group A are an excellent alternative to surgery. The injection of botulinum toxin takes less time and with the correct dosage and compliance with the protocol of its administration causes much fewer complications. The study presented here is devoted to the disclosure of the potential of this tool in esthetic dentistry.","PeriodicalId":397025,"journal":{"name":"Botulinum Toxin - Recent Topics and Applications [Working Title]","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130955468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Pharmacology of Botulinum Toxin Type A","authors":"Anna V. Reznik","doi":"10.5772/intechopen.101315","DOIUrl":"https://doi.org/10.5772/intechopen.101315","url":null,"abstract":"The aim of this chapter is to structure current information clarifying the most disputable issues of botulinum neurotoxin type A (BoNT/A) pharmacology after systemic (botulism) impact and local medical application. Botulinum neurotoxin (BoNT) pharmacological features evaluated open ways to study factors affecting its biological activity: to extend/shorten its effect duration, to increase/decrease BoNT sensitivity in specific patient populations. The chapter presents unique molecular mechanisms underlying BoNT/A pharmacokinetics and pharmacodynamics: entering the body, distribution, receptor binding, translocation, mediator release suppression, zinc metabolism as well as factors affecting body sensitivity to BoNT at each of those stages. The specific biological effects of BoNT/A, which may underlie its analgesic, anticancer and anti-inflammatory effects, are described. Botulinum neurotoxin pharmacokinetics and pharmacodynamics features discussed herein represent significant clinical relevance since they determine botulinum treatment safety and effectiveness. And also they open ways to develop both BoNT-based therapies and anti-botulinic agents.","PeriodicalId":397025,"journal":{"name":"Botulinum Toxin - Recent Topics and Applications [Working Title]","volume":"204 ","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114088773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}