Journal of Analytical, Bioanalytical and Separation Techniques最新文献

{"title":"Biofield Energy Treatment: Physicochemical and Thermal Characterization of L-Tryptophan","authors":"Dahryn Trivedi, M. Trivedi, A. Branton, G. Nayak, S. Jana","doi":"10.15436/2476-1869.19.2401","DOIUrl":"https://doi.org/10.15436/2476-1869.19.2401","url":null,"abstract":"L-tryptophan is an essential amino acid that needs to be supplemented through protein-rich diet and it helps in growth and nitrogen balance in the humans.The aim of this studyis to evaluate the effect of the Trivedi Effect®-Consciousness Energy Healing Treatment on the L-tryptophan in terms of its physicochemical and thermal properties by usingmodern analytical techniques. The method involved dividing the testsample into two parts and providing the Consciousness Energy Healing Treatmentto one part (named as Biofield Energy Treated sample), remotely by a renowned Biofield Energy Healer, Dahryn Trivedi; while the other part didn’t receive any treatment called a control sample. The particle size values of the treated sample was increased by 4.77% (d10), 6.37% (d50), 6.72% (d90), and 6.49% {D(4,3)}; thus, the specific surface area was increased by 4.35% comparedto the control sample. The PXRD peak intensitiesand crystallite sizes of the treated sample were significantly altered ranging from -82.69% to 30.54% and -17.15% to 179.73%, respectively, in comparison to the control sample. The total weight loss of the treated sample was significantly reduced by 11.60% during the heating process that resulted in a significant increase in the residual amount of the sample by 1093.33% as compared to the control sample. The melting temperature and the latent heat of fusion of the treated sample was significantly increased by 1.12% and 6.79%, respectively, compared to the untreated sample. Hence, the L-tryptophan might forma new polymorph after the Trivedi Effect®-Consciousness Energy Healing Treatment that may possess better solubility and bioavailability profile along with improved thermal stability compared with the untreated sample. Thus, the Trivedi Effect®-Consciousness Energy Healing Treatment could be considered as a novel approach for designing the formulations with improved drug profile and efficacy. The treated L-tryptophan would be more useful for the treatment of mental health disorders, premenstrual dysphoric disorder (PMDD), attention deficit-hyperactivity disorder (ADHD), obsessive-compulsive disorder, depression, and bipolar disorder, etc.","PeriodicalId":394819,"journal":{"name":"Journal of Analytical, Bioanalytical and Separation Techniques","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126312512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of the Physicochemical and Thermal Characterization of Biofield Energy Treated Polylactic-co-glycolic acid (PLGA)","authors":"S. Jana, A. Branton, M. Trivedi, Dahryn Trivedi, G. Nayak, Ommega Internationals","doi":"10.15436/2476-1869.19.2026","DOIUrl":"https://doi.org/10.15436/2476-1869.19.2026","url":null,"abstract":"Polylactic-co-glycolic acid (PLGA) is a biodegradable copolymer. It has many applications in the pharmaceuticals and biomedical industries, but its degradation and stability is a major concern. The objective of this study was to evaluate the influence of the Trivedi Effect® on the physicochemical and thermal properties of PLGA using modern analytical techniques. The PLGA sample was divided into control and Biofield Energy Treated parts. The control sample did not obtain the Biofield Energy Treatment, whereas the treated PLGA was received the Trivedi Effect®-Consciousness Energy Healing Treatment remotely by a renowned Biofield Energy Healer, Alice Branton. The particle size values of the treated PLGA were increased by 8.97%(d10), 8.79%(d50), 4.72%(d90), and 6.61%{D(4,3)}; thus, the surface area of treated PLGA was significantly decreased by 6.84% compared with the control sample. The latent heat of evaporation and fusion of the treated PLGA were significantly increased by 29.60% and 230.93%, respectively compared with the control sample. The residue amount was significantly increased by 21.99% in the treated PLGA compared to the control sample. The maximum thermal degradation temperature of the treated PLGA was increased by 2.30% compared with the control sample. It was concluded that the Trivedi Effect®-Consciousness Energy Healing Treatment might have generated a new form of PLGA which may show better powder flow ability, thermal stability, and minimize the hydrolysis of the ester linkages of PLGA. This improved quality of PLGA would be a better choice for the pharmaceutical formulations (i.e., the drug like simvastatin, amoxicillin, and minocycline loaded PLGA nanoparticles) and manufacturing of biomedical devices, i.e., grafts, sutures, implants, surgical sealant films, prosthetic devices, etc., in the industry using it as a raw material.","PeriodicalId":394819,"journal":{"name":"Journal of Analytical, Bioanalytical and Separation Techniques","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127631705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of an HPLC Method Devised for the Quantitative Determination of Ropivacaine in Drug-Delivery Systems","authors":"E. Paula, A. Vieira, M. Franz-Montan, L. F. Cabeça, Ommega Internationals","doi":"10.15436/2476-1869.18.1951","DOIUrl":"https://doi.org/10.15436/2476-1869.18.1951","url":null,"abstract":"Local anesthetics are used to alleviate or eliminate acute and chronic pain[1-3]. Ropivacaine (RVC) is a long acting local anesthetic with a chemical structure closely related to other amino-amides cyclic agents: mepivacaine and bupivacaine[3,4]. It is synthesized in the S enantiomeric form, which is less toxic to the Central Nervous and Cardiac systems[5]. Furthermore, studies in animals and humans suggest that RVC induces less motor block compared to bupivacaine, given the greater selectivity of the S isomer to sensory nerve fibers[6]. The use of drug-delivery systems (DDS) such as liposomal formulations and cyclodextrin-inclusion complexes, have been proposed to improve the solubility and bioavailability of poorly soluble local anesthetics[7,8]. Nowadays, several DDS based on these two carriers can be found among the commercially available local anesthetics products[9,10]. HPLC is the method-of-choice for quantification of drugs in different fluids due to its sensitivity, reproducibility and specificity. Reports on the literature describe precise methods for the quantification, using HPLC, of local anesthetics in serum[11-13],","PeriodicalId":394819,"journal":{"name":"Journal of Analytical, Bioanalytical and Separation Techniques","volume":"53 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123924683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of Multi-Residue Pesticides in Vegetable Samples Using Solid-Phase Micro-Extraction (SPME) Coupled to Gas Chromatography-Electron-Capture Detector (GC-ECD)","authors":"Rupender Kumari, P. Chaturvedi, R. R. Jha, D. Patel, Ommega Internationals","doi":"10.15436/2476-1869.18.1933","DOIUrl":"https://doi.org/10.15436/2476-1869.18.1933","url":null,"abstract":"A fast, simple, solvent less and inexpensive sample preparation method based on Head space solid-phase micro extraction (HS-SPME) coupled to gas chromatography-electron-capture detector (GC-ECD) is proposed for the determination of mix pesticide residues from vegetable samples. Polydimethylsiloxane (PDMS, 100 μm) fiber was used in this study. The mix pesticides (24 nos.) including organochlorines (15), organophosphates (06) and synthetic pyrethriods (03) were analysed in the vegetable samples (Cabbage, Tomato, Cauliflower, Chilli, Okra, Brinjal, Bottle gourd, Cucumber, Beetroot, Spinach, and Radish) collected from in and around of Lucknow city, India. Present study revealed the presence of HCH, DDT, methylparathion, malathion, chlorpyrifos, monocrotophos, endosulfan, cypermethrin, fenvalerate pesticides. Pesticides residue levels were compared with MRL fixed by Prevention of Food Adulteration Act (PFA), Govt. of India 1954. The method detection limits were in a linearity range of 0.003 - 0.024 mg/kg. A recovery percent varies from 86.1 to 96.4% with relative standard deviation (RSD) of 14%. The outcomes of the present study point towards the crucial need of implementing strict government’s rules related to food safety in order to put check on these kinds of health hazardous food contamination.","PeriodicalId":394819,"journal":{"name":"Journal of Analytical, Bioanalytical and Separation Techniques","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132218569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}