{"title":"基于分子模拟技术筛选南美白对虾胶原蛋白中的抗氧化肽","authors":"天畅 邹","doi":"10.52810/cjns.2024.004","DOIUrl":"https://doi.org/10.52810/cjns.2024.004","url":null,"abstract":"本研究以生物信息学技术为基础,利用计算机模拟酶解、相关活性预测与评价、药物代谢动力学及分子模拟技术对南美白对虾胶原蛋白抗氧化肽进行筛选。通过 BIOPEP-UWM 模拟酶解、Peptide Ranker 评分得到具有生物活性的小分子肽,同时采用 ToxinPred、Innovagen 及 Expasy 进一步分析肽段的理化性质,并通过药物代谢动力学 ADMET 分析对肽段进行筛选,得到 2 条无毒、无致敏性、无致突变性、无致癌性及水溶性良好的小分子肽,采用分子对接技术将 AWW、HL 两种抗氧化肽与超氧化物歧化酶 ( superoxide dismutase,SOD) 结合,对其最优复合物进行构象分析。结果显示,AWW、HL 抗氧化肽可在人体中较好地发挥抗氧化活性,本方法为天然食品源抗氧化肽的高效、快速、低成本筛选提供了新思路。","PeriodicalId":39467,"journal":{"name":"Journal of Quality","volume":"1 1","pages":"43-51"},"PeriodicalIF":0.0,"publicationDate":"2024-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.aspub.org/cjns/article/download/11/9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147916082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4