C95. WORLD TRADE CENTER 20TH ANNIVERSARY AND BEYOND最新文献

{"title":"Alveolar Macrophages and Epithelial Cells Express RAGE in a Murine Model of WTC-Particulate Matter Exposure","authors":"A. Veerappan, M. Sunseri, I. Young, A. Nolan","doi":"10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a4792","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a4792","url":null,"abstract":"","PeriodicalId":391666,"journal":{"name":"C95. WORLD TRADE CENTER 20TH ANNIVERSARY AND BEYOND","volume":"295 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121332111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"World Trade Center Particulate Matter-Induced Cardiorespiratory and Vascular Dysfunction (CaRVD) and Obstructive Airways Disease","authors":"S. Kwon, G. Crowley, Mengxing Liu, R. Zeig-Owens, A. Mueller, D. Prezant, A. Nolan","doi":"10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a4789","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a4789","url":null,"abstract":"","PeriodicalId":391666,"journal":{"name":"C95. WORLD TRADE CENTER 20TH ANNIVERSARY AND BEYOND","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127909091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"World Trade Center (WTC) Exposure Community Survivors with Uncontrolled Lower Respiratory Symptoms: Molecular Clustering Analysis","authors":"G. Grunig, N. Durmus, Y. Zhang, S. Pehlivan, Y. Wang, K. Doo, K. Berger, Mengxing Liu, Y. Shao, J. Reibman","doi":"10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a4790","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a4790","url":null,"abstract":"","PeriodicalId":391666,"journal":{"name":"C95. WORLD TRADE CENTER 20TH ANNIVERSARY AND BEYOND","volume":"75 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127371777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lung Cancer Characteristics in Women in the World Trade Center Environmental Health Center","authors":"N. Durmus, S. Pehlivan, Y. Zhang, Y. Shao, A. Arslan, E. Shum, J. Reibman","doi":"10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a4794","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a4794","url":null,"abstract":"","PeriodicalId":391666,"journal":{"name":"C95. WORLD TRADE CENTER 20TH ANNIVERSARY AND BEYOND","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115305615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Prospective Longitudinal Assessment of Nutrition in the FDNY World Trade Center-Exposed Cohort: An Update","authors":"R. Lam, S. Kwon, G. Crowley, R. Zeig-Owens, A. Mueller, D. Prezant, A. Nolan","doi":"10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a4796","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a4796","url":null,"abstract":"RATIONALE Metabolic syndrome phenotypic characteristics and nutritional intake are modifiable biomarkers of particulate matter (PM) associated aerodigestive and cardiovascular disease. Nutritional questionnaires, such as the Rapid Eating Assessment for Participants (REAP-S), can assess the dietary phenotype of our FDNY World Trade Center-Health Program (WTC-HP) cohort. METHODS Cardiovascular disease (CVD) included myocardial infarction, stroke, unstable angina, coronary artery surgery/angioplasty, or CVD related death. Gastroesophageal reflux disease (GERD) cases were WTC-certified cases. WTC-Lung Injury (WTC-LI) was defined as FEV1<LLN at any time point after 9/11. REAP-S was deployed in the WTC-HP annual monitoring assessment. Clinical and REAP-S data accrued from March, 2018 to October, 2021. Scores (ranging 15-39) were categorized into low-dietary [15-19], moderate-dietary [20-29], and high-dietary [30-39] quality. REAP-S questions were assessed as distinct food categories. Mean± standard deviation (SD) expressed as continuous variables. Student t-tests compared clinical data of those with and without disease. One-way ANOVA was used in a subgroup analysis. Arrival time data, used as a proxy for WTC-particulate matter (WTC-PM) exposure, was a dichotomous variable. RESULTS Subjects (N=3,508) completed REAP-S after the database lock date(July 17, 2019) for our prior publication. Mean REAP-S score for the overall cohort(N= 4,073) was 26.48±4.61. CVD patients, had a mean REAP-S score of 26.51±4.43, age (years) at 9/11 was 44.62±7.02, and BMI (kg/m2) was 30.25±4.41. GERD patients, had a mean REAP-S score of 26.50±4.61, age at 9/11 was 41.03±6.95, and BMI was 29.91±4.32. WTC-LI subjects had a mean REAP-S of 26.40±4.39, age of 40.52±7.13, and BMI was 30.31±4.92. When WTC-LI subjects were categorized into dietary quality groups, it was found that their BMI significantly differed from each other, p=0.034. Subjects that complete their questionnaire after July 17, 2019-prior data lock date, had significantly lower mean REAP-S when compared to those with pre-July 17, 2019 data;26.01±4.46 vs 29.43±4.39 respectively, p<0.001. When comparing those with or without CVD or GERD, there was no significance between their average REAP-S score. CONCLUSIONS The implementation of REAPS into the FDNY WTC-HP annual questionnaire remains successful. Continued accrual of data of these unique dietary phenotypes within our cohort will further enrich our longitudinal data set. While it is unclear why more recent REAP-S data is significantly different, possible contributors include societal and clinical stressors such as aging, COVID-19, and confounding comorbidities. Future studies could focus on further defining and intervening on these risk factors to more positively impact on WTC-aerodigestive and cardiovascular disease.","PeriodicalId":391666,"journal":{"name":"C95. WORLD TRADE CENTER 20TH ANNIVERSARY AND BEYOND","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121518152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of EEG Markers of Disturbed Sleep in World Trade Center (WTC) Rescue and Recovery Workers and Volunteers","authors":"A. Mullins, A. Parekh, B. Castillo, D.H. Kim, R. Schoenholz, K. Black, S.-E. Lu, D. Rapoport, R. E. de la Hoz, J. Sunderram, I. Ayappa","doi":"10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a4795","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a4795","url":null,"abstract":"","PeriodicalId":391666,"journal":{"name":"C95. WORLD TRADE CENTER 20TH ANNIVERSARY AND BEYOND","volume":"53 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127226597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utilization of Allergy and Immunology Services Among Rescue Workers Exposed to the World Trade Center Disaster","authors":"D. Caruana, G.T. Smith, P. H. Huang, A. Szema","doi":"10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a4791","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a4791","url":null,"abstract":"RATIONALE: Over 400,000 individuals are estimated to have been exposed to the fallout of the World Trade Center (WTC) disaster. The incidence of acquired allergy and lung injury among rescue and cleanup workers exposed to the WTC fallout has been established. Briefly, rescue and cleanup workers exposed to the WTC fallout had a high incidence of allergic hypersensitivity and permanent small airways dysfunction characterized by distal airways narrowing and airway hyperresponsiveness. The current study sought to quantify the utilization of allergy/immunology services among rescue and cleanup workers exposed to the WTC fallout. METHODS: Subjects (N=65) were referred from the WTC Health Program to a multispecialty allergy/immunology and pulmonology clinic for provision of allergy-immunology specialty services. Electronic health records of all subjects were retrospectively reviewed from the date of first referral to March 2020-when routine care was interrupted due to the coronavirus disease 2019 pandemic-to quantify utilization of allergy/immunology and pulmonology services;10 subjects were excluded from analysis due to incomplete health records. RESULTS: On average, time to referral for allergy-immunology services by the WTC Health Program was 15.2 years (SD=1.7). The majority of the subjects were male (89.1%), police officers (67.3%) who never smoked (65.5%) and had no history of allergic or respiratory disease prior to being exposed to the WTC fallout. Most were found to have environmental allergies (83.6%);the most common comorbidities were allergic rhinitis (89.1%), asthma (67.3%), and chronic sinusitis (63.6%). All subjects underwent environmental allergy testing. Most subjects-35 of 55 (63.6%)-were prescribed an epinephrine autoinjector for environmental allergies. Regarding allergic immunotherapy (IT), 33 of 55 (60.0%) received IT;additionally, 7 subjects (12.7%) were determined to be IT candidates but did not receive IT. The most common monoclonal antibody therapy used in this cohort was omalizumab (18.2%). Only 11 (20.0%) and 3 (5.5%) underwent serum IgE and IgG testing, respectively. CONCLUSION: Rescue and cleanup workers referred to a multispecialty allergy/immunology and pulmonology practice from the WTC Health Program not only had a high incidence of acquired allergies to environmental allergens, but the majority were prescribed and epinephrine autoinjector and either received or were candidates to receive allergy immunotherapy. Given that hundreds of thousands of individuals were exposed to the WTC fallout and exposure is an independent risk factor for developing allergic disease, this research may have identified ways we may be falling short in providing allergy/immunology services to exposed individuals.","PeriodicalId":391666,"journal":{"name":"C95. WORLD TRADE CENTER 20TH ANNIVERSARY AND BEYOND","volume":"73 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122678606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Microbiome of Inflammation and Nutrition: World Trade Center FIREHOUSE RCT","authors":"J. Kim, R. Lam, W. Phillips, S. Kwon, G. Crowley, D. Prezant, A. Nolan","doi":"10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a4793","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a4793","url":null,"abstract":"","PeriodicalId":391666,"journal":{"name":"C95. WORLD TRADE CENTER 20TH ANNIVERSARY AND BEYOND","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130852447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}