Scandinavian Journal of Materials Science最新文献

筛选

英文中文

Scandinavian Journal of Materials Science 斯堪的纳维亚材料科学杂志

Scandinavian Journal of Materials Science Pub Date : 2021-11-23 DOI: 10.2340/scandjms.v1.883

H. Engqvist, H. Haugen

引用次数: 0

Oral Administration of Zolpidem Tartrate in an Abuse-deterrent Formulation Versus an Immediate Release Formulation in Beagle Dogs 酒石酸唑吡坦在比格犬中的防滥用制剂与即刻释放制剂的口服应用

Scandinavian Journal of Materials Science Pub Date : 2021-10-19 DOI: 10.2340/scandjms.v1.41

Amina Vazda, W. Xia, H. Engqvist

{"title":"Oral Administration of Zolpidem Tartrate in an Abuse-deterrent Formulation Versus an Immediate Release Formulation in Beagle Dogs","authors":"Amina Vazda, W. Xia, H. Engqvist","doi":"10.2340/scandjms.v1.41","DOIUrl":"https://doi.org/10.2340/scandjms.v1.41","url":null,"abstract":"Objective: The continuing rise of prescription drug abuse has greatly necessitated the development of an abuse-deterrent formulation. Geopolymers are a promising base for drug design as they allow for tuneable drug release and possess superior physical and chemical properties compared with conventional pharmaceutical excipients.Methods: Geopolymer pellets containing zolpidem tartrate were administrated orally to beagle dogs as a controlled-release formulation with the commercial immediate-release product, Stilnoct® tablets, as the control.Results: The administration of zolpidem tartrate as immediate-release tablets demonstrated an elevated immediate release plasma profile and the zolpidem tartrate in the geopolymers demonstrated a controlled-release plasma profile. The pharmacokinetic analysis demonstrated that immediate-release tablet administration generated much higher plasma concentration when compared with geopolymer pellets administration for zolpidem tartrate. On the other hand, the geopolymer formulation prolonged the time of drug release.Conclusion: Oral administration of zolpidem tartrate in geopolymer pellets demonstrated a controlled-release plasma profile.","PeriodicalId":387023,"journal":{"name":"Scandinavian Journal of Materials Science","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130595812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1