Vaccines Research and Vaccination最新文献

{"title":"Recruitment and Retention of Participants from Fishing Communities of Lake Victoria in the First Phase I HIV Vaccine Trial in this Community: Experiences of the EV06 Study","authors":"A. Nanvubya","doi":"10.24966/vrv-0193/100008","DOIUrl":"https://doi.org/10.24966/vrv-0193/100008","url":null,"abstract":"Recruitment and Retention of Participants from Fishing Communities of Lake in the First Phase I HIV Vaccine Trial in this Community: Experi- ences of the EV06 Study. J Vaccines Res Vaccin 5: 008. , , Abstract Introduction Fishing communities are a new “Most at Risk Population for HIV in sub-Saharan Africa”. If they are to successfully participate in HIV prevention trials, researchers must demonstrate that they can recruit and retain them in these trials. We assessed the recruitment and retention rates of the first phase 1 HIV vaccine trial among fishing communities in Uganda. Methods Adult participants (18-45 years) identified through community ed - ucation seminars on the shores of Lake Victoria and surrounding villages were invited to two study clinics in Entebbe and Masaka, Uganda for screening and possible enrolment into a randomized control HIV Vaccine trail. Detailed study information was given and written informed consent obtained from each participant. Eligibility for enrolment was based on low HIV risk profile, helminthic sta - tus, demonstration of understanding of the study, availability for 9 months’ follow-up, contraceptive use and clinical and laboratory assessments. Proportions of volunteers screened, enrolled and followed up were measured. Proportions of reasons for screen failure were also measured. Recruitment took approximately 6 months between November 2014 and April 2015. A total of 338 participants (124, 37% females) were screened to enroll 72 (24, 33% females) giving a screening to enrolment ratio of 5:1. Screen failure reasons included; helminthic infection (153, 51%), high HIV risk behavior (37, 12%), unavailability for follow-up (26, 9%), hepatitis B or C infection (23, 8%), medical illness/abnormal history (21, 7%), HIV infection (7, 2%), abnormal laboratory results (6, 2%), pregnancy (4, 1%) and other reasons (8, 3%). A retention rate of 100% was achieved at the end of the 9 months’ follow-up. We conclude that despite a substantial proportion of screen fail- ures, it was possible to recruit and retain participants in the first ever HIV vaccine trial from a community that is quite mobile and at high risk of HIV-1 infection. It is important to engage fishing communities in HIV prevention research as this key population will help research- ers better understand the HIV/AIDS epidemic in Uganda.","PeriodicalId":382817,"journal":{"name":"Vaccines Research and Vaccination","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124143900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}