Trends in Vaccines and Immunology最新文献

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Conversion of IgM to IgG by Lysates of Burkitt’s Lymphoma Cells 伯基特淋巴瘤细胞裂解液中IgM转化为IgG的研究
Trends in Vaccines and Immunology Pub Date : 1900-01-01 DOI: 10.31038/tvi.2021111
R. Bases, R. Lekhraj, Seema Gollamudi, E. Nieves
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引用次数: 0
The Trojan Horse Strategies of Parasites 寄生虫的特洛伊木马策略
Trends in Vaccines and Immunology Pub Date : 1900-01-01 DOI: 10.31038/tvi.2021121
A. Scovino, A. Trigueiros, A. Morrot
{"title":"The Trojan Horse Strategies of Parasites","authors":"A. Scovino, A. Trigueiros, A. Morrot","doi":"10.31038/tvi.2021121","DOIUrl":"https://doi.org/10.31038/tvi.2021121","url":null,"abstract":"Trends in Vaccines and Immunology, Volume 1(2): 1–2, 2021 The Trojan Horse is a legendary figure of a wooden horse used by the Greeks during the Trojan War to invade and destroy the Trojan city. Inside this seemingly harmless horse, supposedly sent as a sign of truce, were Greek warriors who at dusk, when the Trojan defenses were unarmed, took advantage to attack the city. This legendary figure can be used as an excellent analogy for the mechanisms some pathogens have adopted to invade the host and evade detection by the immune system. The ‘Trojan Horse Theory’ in immunology describes the ability of some microorganisms, using cells of the immune system itself as vectors, to escape the immune response.","PeriodicalId":379971,"journal":{"name":"Trends in Vaccines and Immunology","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130705585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Do Pathogenic Chronic Infections Cause Host Senescence? 致病性慢性感染会导致宿主衰老吗?
Trends in Vaccines and Immunology Pub Date : 1900-01-01 DOI: 10.31038/tvi.2021122
A. Scovino, A. Trigueiros, A. Morrot
{"title":"Do Pathogenic Chronic Infections Cause Host Senescence?","authors":"A. Scovino, A. Trigueiros, A. Morrot","doi":"10.31038/tvi.2021122","DOIUrl":"https://doi.org/10.31038/tvi.2021122","url":null,"abstract":"hemoglobin molecules (hemichromes), are recognized as antigens by autologous IgG antibodies and complement system. With the deposition of a critical density of antibodies and complement molecules, senescent red blood cells are recognized and eliminated [5]. The senescent red blood cells expose phosphatidylserine on the outer portion of their plasma membrane, a sign that indicates that the cell should be phagocytosed. In healthy cells this phospholipid is actively maintained in the cytoplasmic portion of the plasma membrane. Concomitantly, there is down-regulation of the CD47 molecule, a transmembrane protein whose normal expression indicates a non-phagocytic signal. The exposure of phosphatidylserine coupled with the reduction of CD47 expression stimulates phagocytosis and the elimination of these red blood cells [6]. In 2001, Bratosin [7] and colleagues described a process similar to apoptosis occurring in red blood cells, later called erythrosis [8]. Eryptosis has several similarities to apoptosis, regardless of the trigger, induction of an eripotic state usually involves extracellular calcium entry into the cell, caspase and calpain activation, which causes changes in membrane asymmetry, phosphatidylserine exposure and cell shrinkage. and membrane.","PeriodicalId":379971,"journal":{"name":"Trends in Vaccines and Immunology","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130452247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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