{"title":"Cases of 193 Inpatients and Caregivers with COVID-19 Negative Conversion Positive— A Single-Center Analysis","authors":"Chuang Yang, Luobu Ouzhu, Caihong Hao, Enya Ning","doi":"10.53043/jvvd-3-001","DOIUrl":"https://doi.org/10.53043/jvvd-3-001","url":null,"abstract":"Background: A sudden outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in the Tibetan Autonomous Region in August 2022 disrupted the coronavirus disease 2019 (COVID-19)-free status of the Tibetan over the past 3 years and poses severe risks to public health. Methods: A total of 2966 patients and caregivers were admitted to our hospital from August 01, 2022 to October 10, 2022 and cases of negative-to-positive conversion were analyzed during hospitalization. Results: In total, 193 cases of negative-to-positive conversion were identified. The rates of hospitalization for adults (age, ≥15 years), children (age, 0–14 years), and caregivers were 4.04%, 3.07%, and 5.94%, respectively. For the majority of COVID-19 cases, negative-to-positive conversion occurred within 1–4 days. The rates of cases with mild, moderate, and severe symptoms were 41.45%, 46.63%, and 11.92%, respectively. The Tibetan population accounted for 86.01% of all positive cases. Conclusion: Mutant variants of SARS-CoV-2 can adapt to harsh conditions at high altitudes and spread among local populations, suggesting that infection prevention and control efforts should be continued in some regions to protect public health.","PeriodicalId":377820,"journal":{"name":"Journal of Virology and Vaccine Development","volume":"49 9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130635810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Fast Track Diagnostic Requisite for Sepsis and its Antimicrobial Resistance in Low Resource Settings: A Step Towards Antimicrobial Stewardship","authors":"D. Minal, Amrita A. Khaire","doi":"10.53043/jvvd-3-002","DOIUrl":"https://doi.org/10.53043/jvvd-3-002","url":null,"abstract":"Sepsis due to multidrug resistant bacteria (MDR) is a growing challenge. WHO developed the global action plan on antimicrobial resistance and adopted a resolution for improving the prevention, diagnosis and clinical management of the sepsis. At an early stage, sepsis frequently remains under-diagnosed when it is potentially reversible. Laboratories in low resource settings often face the issue of poor infrastructure, irregular supply of reagents, maintenance and new investment costs. Currently, molecular diagnostics have met the criteria of rapidity, ease of use, cost, automation and can be used for point-of-care (POC) testing. However, there scarcity of POC diagnostics in the resource limited settings. The present review describes real time polymerasebased tests and commercially available systems for their capability for bacterial and resistance profile detection. We highlight the need for innovative, small and cost-effective POC devices for clinical utility. It will help to plan more effective antibiotic treatments and quality of health care services in developing countries.","PeriodicalId":377820,"journal":{"name":"Journal of Virology and Vaccine Development","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121788835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}