Journal of Infectious Diseases & Preventive Medicine最新文献

{"title":"Tetanus in Women of Childbearing Age at Brazzaville University Hospital: Prevalence and Associated Factors","authors":"O. Br, Adoua Dt, M. Ekat, Ekouya Bg, Ellenga Mfb, M. Amona, Angonga Pe, Bitséné Mg, S Poutoukoue, C. Itoua","doi":"10.35248/2329-8731.19.7.189","DOIUrl":"https://doi.org/10.35248/2329-8731.19.7.189","url":null,"abstract":"Objective: To determine the prevalence of tetanus in women of childbearing age and to find out associated factors. Patients and Methods: Prospective study for descriptive and analytical purposes of tetanus cases in women of reproductive age registered in the Infectious Diseases Department at the Brazzaville University Hospital between January 1st, 2018 and July 31st, 2019. Results: Fifty-one cases of patients were collected (4.02% of admissions) with mean age 24.22 ± 10.38 (15-49 years), female students (n=31, 60.78%), single (n=43, 84.3%), low socio-economic status (n=33, 65.35%) and immunodepressed with HIV type 1 (n=10, 19.60%), (n=43, 84.31%). Patients lived in city (n=43, 84.31%). Immunization status was doubtful and absent respectively in 20 cases (39.21%). Patients had an average delay of 94.56 ± 45.38 hours (48-336) for trismus (n=41, 80.4%), other contractures (n=8, 15.7%), and paroxysms (2, 3.9%). Tetanus was generalized at admission (n=49, 96.1%), without complication (n=46, 90.2%). The entryway was integumentary (n=35, 68.6%), intramuscular (n=10, 19.6). The antitetanus serum was administered to all patients (100%) but suboccipital serum in only three patients (5.9%). In thirty patients (58.8%), the trimming of the entryway has not been realized. The Dakar score was ranked 3 in 25 patients (49.0%) and the mean duration of hospitalization was 10.55 ± 6.22 days (range 1-30). The evolution was favorable for thirty four patients (66.7%). The IM (p=0.000) and integumentary (p=0.003) and the Dakar 3 (p=0.000) gateways had a connection to the occurrence of death. Conclusion: The situation of tetanus in women of childbearing age is worrying at the University Hospital of Brazzaville with a high prevalence despite the existence of a vaccine. It is therefore important to prevent this disease by systematizing tetanus vaccination within this target population group.","PeriodicalId":377313,"journal":{"name":"Journal of Infectious Diseases & Preventive Medicine","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129176324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Towards an HIV Vaccine Based on Immune Network Theory II","authors":"G. Hoffmann, Teri Otto, M. Grant, S. Muller, H. Kohler","doi":"10.35248/2329-8731.19.7.190","DOIUrl":"https://doi.org/10.35248/2329-8731.19.7.190","url":null,"abstract":"We have designed immunization protocols based on the co-section model to induce a broadening antigen antibody response against HIV1. As antigen were various antigen-antibody complexes used, including the monoclonal antibody 1F7 that is expressed on anti-HIV1 antibodies with different antigen specificities. \u0000 \u0000Rabbits were used to test this concept using. Antibodies that neutralized HIV-1 of the same strain as that of the gp120 used were detected, but they did not include broadly neutralizing antibodies (BnAbs). Immunization with gp120 in adjuvant induced antibodies binding to gp120, gp41, Nef and p24, a finding predicted by the immune network theory. Furthermore a complex of 1F7 and B12 induced antibodies against gp120 and gp41, demonstrating an antigen broadening response towards achieving the goal of inducing BnAbs through immunization.","PeriodicalId":377313,"journal":{"name":"Journal of Infectious Diseases & Preventive Medicine","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133663776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowing the Profile of Clients from the Screening and Information Centre (CADI) for Better Planning and Case Management in Bobo-Dioulasso, Burkina Faso","authors":"A. Poda, I. Da, Z. Méda, S. Somda, I. Traoré, A. Héma, I. Sombié, M. Traoré, N. Meda","doi":"10.35248/2329-8731.19.7.188","DOIUrl":"https://doi.org/10.35248/2329-8731.19.7.188","url":null,"abstract":"Background: Counselling associated with screening is the entry point into the management for HIV-infected people. The purpose of the present study was to compare the profile of clients from the Screening and Information Centre (CADI) with those from the general population. \u0000 \u0000Methods: A cross-sectional study including all complete medical records of CADI clients from 1996 to 2006 was conducted. The following information were collected: age, sex, education level, marital status, reasons for screening, desire to share one’s HIV status. The data were analyzed using stata13 software. Pearson khi2 Test was used to compare qualitative variables while Student Test was used to compare averages. The 0.05 significance level was applied. \u0000 \u0000Results: A sample of 752 observations was analyzed. In 1996, the average age of CADI clients was (29.95 years [29.79 -31.26]) higher than the average age of the general population (21.7 years; p<0.0001). The proportion of women tested at CADI was similar to the proportion of the general population (p=0.980). The proportion of educated clients (73.03%) was higher than the general population (76.3%; p<0.0001), with the same applying for people living in couple (49.15%; p<0.0001) and workers (58.65%; p<0.0001). In 2006, the average age of people tested at CADI (30.62 years) was higher than the average age of the general population (21.7 years; p<0.0001). The proportion of women attending CADI (61.7%) was significantly higher than in the general population (51.7%; p<0.0001). The proportion of educated clients (75.56%) was also higher than the general population (26.1%; p<0.0001). The proportion of CADI clients living in couple was higher (58.93%) although it was low in the general population (0.6%; p<0.0001). \u0000 \u0000Conclusion: The profile of CADI clients is different from the profile of the general population. Further action must therefore be taken for greater awareness among the less adhering to HIV screening.","PeriodicalId":377313,"journal":{"name":"Journal of Infectious Diseases & Preventive Medicine","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129522052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}