Chemical Biology Letters最新文献

Global Cancer Etiology: Molecular Signatures, Therapeutic Disparities, and the role of Socio-economic Determinants. 全球癌症病因学：分子特征、治疗差异和社会经济决定因素的作用。

IF 5.6

Chemical Biology Letters Pub Date : 2026-04-16 Epub Date: 2026-05-07 DOI: 10.62110/sciencein.cbl.2026.v13.1764

Param Patel, Michael Oh, Keykavous Parang

{"title":"Global Cancer Etiology: Molecular Signatures, Therapeutic Disparities, and the role of Socio-economic Determinants.","authors":"Param Patel, Michael Oh, Keykavous Parang","doi":"10.62110/sciencein.cbl.2026.v13.1764","DOIUrl":"10.62110/sciencein.cbl.2026.v13.1764","url":null,"abstract":"The global burden of cancer is increasingly shaped by socio-economic determinants that extend beyond geographic incidence patterns. While historically considered a disease of affluence, cancer now reflects a divergence between high-income countries (HICs) and low- and middle-income countries (LMICs), driven by distinct environmental, occupational, and structural exposures. This narrative review examines how socio-economic conditions act as primary determinants of cancer etiology by linking epidemiological trends to molecular evidence. A comprehensive literature search was conducted (2006-2026), focusing on cancer etiology, environmental carcinogenesis, mutational signatures, and health disparities. Three domains of socio-economic influence emerged from search. First, harmful exposures, including asbestos, aflatoxin B1, arsenic, heavy metals, and air pollution, are disproportionately concentrated in under-regulated populations. Second, these exposures produce distinct mutational signatures; aflatoxin-related hepatocellular carcinoma is associated with TP53 R249S and COSMIC Signature 24, while cancers in HICs often involve PI3K/AKT/mTOR pathway alterations. Third, disparities in screening infrastructure create \"screening deserts,\" increasing mortality gaps. Socio-economic context fundamentally shapes cancer biology, incidence, and outcomes. Reducing disparities requires expanded genomic capacity in LMICs, targeted prevention strategies, and equitable access to precision oncology.","PeriodicalId":37411,"journal":{"name":"Chemical Biology Letters","volume":"13 2","pages":""},"PeriodicalIF":5.6,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13238271/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148200300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cyclic-Linear Hybrid Peptides as Molecular Transporters of Chemotherapeutic Agents. 循环-线性杂化肽作为化疗药物的分子转运体。

IF 5.6

Chemical Biology Letters Pub Date : 2026-02-02 Epub Date: 2026-02-09 DOI: 10.62110/sciencein.cbl.2026.v13.1753

Jonathan Moreno, Rakesh Kumar Tiwari, Keykavous Parang

{"title":"Cyclic-Linear Hybrid Peptides as Molecular Transporters of Chemotherapeutic Agents.","authors":"Jonathan Moreno, Rakesh Kumar Tiwari, Keykavous Parang","doi":"10.62110/sciencein.cbl.2026.v13.1753","DOIUrl":"10.62110/sciencein.cbl.2026.v13.1753","url":null,"abstract":"Arginine/tryptophan-rich peptides are amphipathic, enabling membrane interaction, cargo transport, and antimicrobial activity. To enhance these properties, we synthesized and evaluated hybrid peptide [RW]4K-AH135 (1), combining the antimicrobial α-helical peptide AH135 (AMP) with the cell-penetrating peptide (CPP) [RW]4K, and [R5W4]K-AH135 (2), combining AH135 with another AMP [R5W4]K. Peptides were synthesized by Fmoc solid-phase peptide synthesis and cyclization in solution phase, purified by HPLC, and characterized by MALDI-TOF. While AH135 and [R5W4] showed antimicrobial activity (MICs 3.1-6.2 μg/mL), both hybrids were inactive (MIC ≥ 50 μg/mL). In contrast, the hybrids functioned as molecular transporters in cancer cells. [R5W4]-AH135 enhanced the activity of multiple chemotherapeutics in MDA-MB-231 and SK-OV-3 cells, improving growth inhibition by approximately 15-47% at 72 h, and improved doxorubicin efficacy by approximately 37% in resistant MES-SA cells. Both hybrids promoted the intracellular delivery of green fluorescent protein (50 nM), as confirmed by flow cytometry and confocal microscopy (p < 0.001). [RW]4K-AH135 showed higher uptake in both lines in a dose- and time-dependent manner. [R5W4]K-AH135 acted as a chemotherapeutic agent sensitizer, whereas [RW]4K-AH135 was a superior carrier. Thus, these hybrids act as molecular transporters and represent promising platforms for drug conjugation and intracellular delivery.","PeriodicalId":37411,"journal":{"name":"Chemical Biology Letters","volume":"13 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13307771/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148346635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reversal of promoter hypermethylation of CADM1 and SOCS1 by leaf extract of Datura metel in cervical cancer cells 曼陀罗叶提取物逆转宫颈癌细胞中 CADM1 和 SOCS1 启动子的高甲基化

IF 2.3

Chemical Biology Letters Pub Date : 2024-01-03 DOI: 10.62110/sciencein.cbl.2024.v11.654

Mahek Sharan, Niraj Kumar Jha, Saurabh Kumar Jha, Abhimanyu Kumar Jha

引用次数: 0

Early manifestation of hyperuricemia and its pathophysiological interface with adiposopathy and metabolic syndrome among young adult: Cross-sectional study 高尿酸血症的早期表现及其与肥胖症和代谢综合征的病理生理学联系：横断面研究

IF 2.3

Chemical Biology Letters Pub Date : 2024-01-03 DOI: 10.62110/sciencein.cbl.2024.v11.653

Shipra Das, Anil Baran Chaudhury, Hemraj Dewangan, K. Bhattacharya, Swaraj Bandhu Kesh, S. Dutta, P. Sengupta

引用次数: 0

Synthesis of Indole-Oxadiazole coupled isoxazole hybrids as potent EGFR targeting anticancer agents 合成吲哚-恶二唑偶联异噁唑杂环作为有效的表皮生长因子受体靶向抗癌剂

IF 2.3

Chemical Biology Letters Pub Date : 2024-01-03 DOI: 10.62110/sciencein.cbl.2024.v11.651

Abhilasha Dubba, Shiva Kumar Koppula

引用次数: 0