发布求助
文献互助 智能选刊 最新文献

Pseudomonas aeruginosa - Biofilm Formation, Infections and Treatments最新文献

筛选
英文 中文
Introductory Chapter: Understanding Infections Caused by Opportunistic Bacterial Pathogens 介绍性章节：了解机会性细菌病原体引起的感染
Pseudomonas aeruginosa - Biofilm Formation, Infections and Treatments Pub Date : 2021-06-09 DOI: 10.5772/INTECHOPEN.97831
T. Das
{"title":"Introductory Chapter: Understanding Infections Caused by Opportunistic Bacterial Pathogens","authors":"T. Das","doi":"10.5772/INTECHOPEN.97831","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.97831","url":null,"abstract":"<jats:p />","PeriodicalId":373681,"journal":{"name":"Pseudomonas aeruginosa - Biofilm Formation, Infections and Treatments","volume":"99 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127665192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Pseudomonas aeruginosa Secreted Biomolecules and Their Diverse Functions in Biofilm Formation and Virulence 铜绿假单胞菌分泌的生物分子及其在生物膜形成和毒力中的多种功能
Pseudomonas aeruginosa - Biofilm Formation, Infections and Treatments Pub Date : 2021-03-22 DOI: 10.5772/INTECHOPEN.96866
T. Das
{"title":"Pseudomonas aeruginosa Secreted Biomolecules and Their Diverse Functions in Biofilm Formation and Virulence","authors":"T. Das","doi":"10.5772/INTECHOPEN.96866","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.96866","url":null,"abstract":"Pseudomonas aeruginosa is an opportunistic Gram-negative bacterium accountable for causing life-threatening infections in humans. According to the World Health Organization, P. aeruginosa classified as a critical pathogen. Specifically, P. aeruginosa in its colonized or biofilm state presents a major infection threat to immunocompromised (HIV) patients, Cystic fibrosis, burns, wounds and surgery associated infection. It is also a common pathogen responsible for causing hospital acquired/nosocomial infection and Urinary tract infections. P. aeruginosa biofilm is made up of bacterial self-synthesized biomolecules includes extracellular DNA, polysaccharides, proteins, RNA, siderophores and metabolites such as pyocyanin. This chapter will elaborate the manifold functions of P. aeruginosa secreted biomolecules in establishing and stabilizing biofilms, triggering virulence and pathogenicity in host, and resisting antibiotics and antibacterial agents.","PeriodicalId":373681,"journal":{"name":"Pseudomonas aeruginosa - Biofilm Formation, Infections and Treatments","volume":"393 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124077043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Pseudomonas aeruginosa Biofilm Lung Infection in Cystic Fibrosis: The Challenge of Persisters 囊性纤维化中铜绿假单胞菌生物膜肺部感染:顽固者的挑战
Pseudomonas aeruginosa - Biofilm Formation, Infections and Treatments Pub Date : 2021-01-29 DOI: 10.5772/INTECHOPEN.95590
G. Mangiaterra, M. Amiri, Nicholas Cedraro, F. Biavasco
{"title":"Pseudomonas aeruginosa Biofilm Lung Infection in Cystic Fibrosis: The Challenge of Persisters","authors":"G. Mangiaterra, M. Amiri, Nicholas Cedraro, F. Biavasco","doi":"10.5772/INTECHOPEN.95590","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.95590","url":null,"abstract":"Pseudomonas aeruginosa lung infection is difficult to eradicate due to the multiple (intrinsic and acquired) antibiotic resistance of bacteria and to their ability to produce a thick biofilm. Antibiotic treatment is hampered by poor antibiotic diffusion, efflux pump overexpression and the development of a persistent subpopulation with low metabolic activity. This is a cause for special concern in Cystic Fibrosis (CF) patients, where P. aeruginosa lung infection is the chief cause of morbidity and mortality. Combined tobramycin-ciprofloxacin treatment is routinely adopted due to the low frequency of resistant strains and its ostensible ability to control the infection. Nevertheless, symptoms usually recur, mainly due to the antibiotic persisters, which are difficult to detect in routine cultural microbiological assays. This chapter describes the issues involved in the microbiological diagnosis of P. aeruginosa lung infection in CF patients and the possible role of subinhibitory antibiotic concentrations in persister development and infection recurrence.","PeriodicalId":373681,"journal":{"name":"Pseudomonas aeruginosa - Biofilm Formation, Infections and Treatments","volume":"513 1-2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134131771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Pseudomonas aeruginosa: Diseases, Biofilm and Antibiotic Resistance 铜绿假单胞菌:疾病、生物膜和抗生素耐药性
Pseudomonas aeruginosa - Biofilm Formation, Infections and Treatments Pub Date : 2020-12-12 DOI: 10.5772/intechopen.95251
H. Al-Dahmoshi, Raad D. Al-Obaidi, N. S. Al-Khafaji
{"title":"Pseudomonas aeruginosa: Diseases, Biofilm and Antibiotic Resistance","authors":"H. Al-Dahmoshi, Raad D. Al-Obaidi, N. S. Al-Khafaji","doi":"10.5772/intechopen.95251","DOIUrl":"https://doi.org/10.5772/intechopen.95251","url":null,"abstract":"Pseudomonas aeruginosa is Gram negative bacteria that can adapt to extreme environmental conditions and withstand to different antibacterial agents. It si responsible for arrays of infections both community and hospital acquired especially ICU infections. Respiratory tract infection, blood stream infection, wound infection, burn infection, and urinary tract infections ware top five P. aeruginosa infections. Additionally as an opportunistic bacteria, it may be associated with healthcare infections in intensive care units (ICUs), ventilator-associated pneumonia (VAP), central line-associated blood stream infections, surgical site infections, otitis media, and keratitis. P. aeruginosa can form biofilms as self-produced extracellular matrix to protects the cells from antibiotics and the host immune response. Antibiotic resistance was an prominent feature of this pathogen and can donate it one of the three resistance patterns: Multidrug (MDR), extensive drug (XDR) and pan drug resistance. It exploit many resistance mechanisms ranged from overexpression of drug efflux systems protein, modifying enzyme production, reducing the permeability and using shelters like biofilms.","PeriodicalId":373681,"journal":{"name":"Pseudomonas aeruginosa - Biofilm Formation, Infections and Treatments","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133036953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：604180095
Book学术官方微信