Helicobacter pylori [Working Title]最新文献

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Helicobacter pylori Genes jhp0940, jhp0945, jhp0947 and jhp0949 are Associated with Gastroduodenal Disease 幽门螺杆菌基因jhp0940、jhp0945、jhp0947和jhp0949与胃十二指肠疾病相关

Helicobacter pylori [Working Title] Pub Date : 2018-11-22 DOI: 10.5772/INTECHOPEN.81290

Romo-González Carolina, Coria-Jiménez Rafael

{"title":"Helicobacter pylori Genes jhp0940, jhp0945, jhp0947 and jhp0949 are Associated with Gastroduodenal Disease","authors":"Romo-González Carolina, Coria-Jiménez Rafael","doi":"10.5772/INTECHOPEN.81290","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.81290","url":null,"abstract":"The plasticity zone (PZ) of Helicobacter pylori is a genomic region harbouring genes that can be exchanged between strains, contributing to the genetic diversity of this bacterium. The presence or absence of genes reflects the adaptation and coevolution of a pathogen within its host. Among the genes present in PZ, jhp0940 , jhp0945 , jhp0947 and jhp0949 have gained attention due to their association with gastroduodenal disease, and the prevalence of the latter three among H. pylori isolates from different geographical regions has allowed this association to be understood. With respect to jhp0940 , also known as ctkA (cellular translocation kinase A), various results have been obtained regarding its prevalence. However, the presence of jhp0940 in isolates from children seems to be higher than that in isolates from adults, and the product of this gene can induce TNF- α , IL-6 and IL-8 via translocation of NF-κ B into macrophages. While little is known about the functions of jhp0945 , jhp0947 and jhp0949 , their presence in H. pylori strains induces IL-8 and IL-12 expression at higher levels than that in strains lacking these genes. In this chapter, we aim to show a general overview of the prevalence, association with gastroduodenal disease, and currently known function of the H. pylori genes jhp0940 , jhp0945 , jhp0947 and jhp0949, which are located in PZ.","PeriodicalId":367380,"journal":{"name":"Helicobacter pylori [Working Title]","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123661782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nonantibiotic-Based Therapeutics Targeting Helicobacter pylori: From Nature to the Lab 针对幽门螺杆菌的非抗生素治疗:从自然到实验室

Helicobacter pylori [Working Title] Pub Date : 2018-11-05 DOI: 10.5772/INTECHOPEN.81248

P. Parreira, C. Seabra, Daniela Lopes-de-Campos, M. Martins

引用次数: 1

Clinical Manifestations of the Epsilonproteobacteria (Helicobacter pylori) 幽门螺杆菌的临床表现

Helicobacter pylori [Working Title] Pub Date : 2018-11-05 DOI: 10.5772/INTECHOPEN.80331

Rie Louise Møller Nordestgaard, M. R. Spiegelhauer, T. Frandsen, C. Gren, A. Stauning, L. Andersen

{"title":"Clinical Manifestations of the Epsilonproteobacteria (Helicobacter pylori)","authors":"Rie Louise Møller Nordestgaard, M. R. Spiegelhauer, T. Frandsen, C. Gren, A. Stauning, L. Andersen","doi":"10.5772/INTECHOPEN.80331","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.80331","url":null,"abstract":"Epsilonproteobacteria is a large group of Gram-negative curved or spiral microaero-philic rods, of which many are difficult to culture. Because this group of bacteria is not very well investigated, our knowledge about them is limited, and a great amount of research is still needed. At least two species are well-established human pathogens: Campylobacter jejuni/coli causing gastroenteritis and Helicobacter pylori causing gastric and extra-gastric manifestations. It is well accepted that H. pylori causes a chronic inflam mation in the stomach and thereby causes H. pylori- associated gastritis, which may or may not be symptomatic. The association between H. pylori and peptic ulcers, MALT lymphomas, gastric cancer, idiopathic thrombocytopenic purpura, and unexplained iron-deficiency anemia (IDA) is strongly evidence based. On the other hand, pernicious (vitamin B12 deficiency) anemia, neuromyelitis optica, asthma, and Graves’ disease are less evidence based. H. pylori may also be associated with cardiovascular disease, pan -creatitis, pancreatic cancer, obesity, diabetes mellitus type 2, Parkinson’s disease, liver diseases, and preeclampsia. H. pylori is thus involved in many gastric and extra-gastric manifestations either directly or indirectly by several proposed mechanisms including antigenic mimicry.","PeriodicalId":367380,"journal":{"name":"Helicobacter pylori [Working Title]","volume":"8 8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124403509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1