Preeclampsia [Working Title]最新文献

Cellular Functions of ER Chaperones in Regulating Protein Misfolding and Aggregation: An Emerging Therapeutic Approach for Preeclampsia 内质网伴侣在调节蛋白质错误折叠和聚集中的细胞功能:一种新兴的治疗子痫前期的方法

Preeclampsia [Working Title] Pub Date : 2021-12-26 DOI: 10.5772/intechopen.101271

Janaranjani Murugesan, Ajithkumar Balakrishnan, Premkumar Kumpati, Hemamalini Vedagiri

{"title":"Cellular Functions of ER Chaperones in Regulating Protein Misfolding and Aggregation: An Emerging Therapeutic Approach for Preeclampsia","authors":"Janaranjani Murugesan, Ajithkumar Balakrishnan, Premkumar Kumpati, Hemamalini Vedagiri","doi":"10.5772/intechopen.101271","DOIUrl":"https://doi.org/10.5772/intechopen.101271","url":null,"abstract":"Proteinuria is one of the hallmarks of preeclampsia (PE) that differentiates other hypertensive disorders of pregnancy. Protein misfolding and aggregation is an emerging pathological condition underlying many chronic metabolic diseases and neurodegenerative diseases. Recent studies indicate protein aggregation as an emerging biomarker of preeclampsia, wherein several proteins are aggregated and dysregulated in the body fluids of preeclamptic women, provoking the multi-systemic clinical manifestations of the disease. At the cellular level, these misfolded and aggregated proteins are potentially toxic interfering with the normal physiological process, eliciting the unfolded protein response (UPR) pathway activators in the endoplasmic reticulum (ER) that subsequently augments the ER quality control systems to remove these aberrant proteins. ER resident chaperones, folding enzymes and other proteins serve as part of the ER quality control machinery in restoring nascent protein folding. These ER chaperones are crucial for ER function aiding in native protein folding, maintaining calcium homeostasis, as sensors of ER stress and also as immune modulators. Consequently, ER chaperones seems to be involved in many cellular processes, yet the association is expanding to be explored. Understanding the role and mechanism of ER chaperones in regulating protein misfolding and aggregation would provide new avenues for therapeutic intervention as well as for the development of new diagnostic approaches.","PeriodicalId":362368,"journal":{"name":"Preeclampsia [Working Title]","volume":"61 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121554065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preeclampsia: From Etiopathology to Organ Dysfunction 子痫前期:从病因到器官功能障碍

Preeclampsia [Working Title] Pub Date : 2021-12-26 DOI: 10.5772/intechopen.101240

Nissar Shaikh, S. Nahid, Firdous Ummunnisa, Ifrah Fatima, Mohamad Hilani, Asma Gul, A. Al Basha, W. Yahia, F. Al Hail, H. Elfil, E. Abdalla, M. Nainthramveetil, M.A Imraan, M. Zubair, Sibghatullah M Khan, N. Korichi, S. AlKhawaga, H. Ismail, S. Yaqoob, Mashael Abdulrahman M. S. Al Khelaifi

引用次数: 1

Ophthalmic Disorders in Posterior Reversible Encephalopathy Syndrome Associated with Preeclampsia 后路可逆性脑病综合征与子痫前期相关的眼部疾病

Preeclampsia [Working Title] Pub Date : 2021-11-14 DOI: 10.5772/intechopen.101270

Katarina Cvitkovic, Anita Pusić Sesar, A. Sesar, I. Čavar

{"title":"Ophthalmic Disorders in Posterior Reversible Encephalopathy Syndrome Associated with Preeclampsia","authors":"Katarina Cvitkovic, Anita Pusić Sesar, A. Sesar, I. Čavar","doi":"10.5772/intechopen.101270","DOIUrl":"https://doi.org/10.5772/intechopen.101270","url":null,"abstract":"Posterior reversible encephalopathy syndrome (PRES) is a clinicoradiological entity presented with different symptoms such as visual disturbances, headaches, seizures, severe hypertension and altered mental status. It has been recognized in a different pathological conditions, although preeclampsia/eclampsia is the most common cause of PRES. The pathogenesis of PRES is still not fully understood, but it seems that failure of cerebrovascular autoregulation causing vasogenic edema, cerebral vasoconstriction, and disruption of the blood brain barrier plays an important role. Cortical blindness, hypertensive retinopathy, serous retinal detachment (SRD), central retinal artery and vein occlusions, retinal or vitreous hemorrhages, anterior ischemic optic neuropathy (AION) and Purtscher’s retinopathy are ophthalmic disorders that may occur in PRES associated with preeclampsia. Among these, cortical blindness is the best documented complication of preeclampsia. Magnet resonance imaging (MRI) is a gold standard to establish the diagnosis of PRES because clinical findings are not sufficiently specific. Typically, there are bilateral cortical occipital lesions with hyperdensity on T2-weighted MRI. Blindness due to occipital lesions is reversible and the vision loss is usually regained within 4 h to 8 days.","PeriodicalId":362368,"journal":{"name":"Preeclampsia [Working Title]","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129919387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of Spiral Steroids in Pregnancy and Pre-Eclampsia 螺旋类固醇在妊娠和先兆子痫中的作用

Preeclampsia [Working Title] Pub Date : 2021-10-13 DOI: 10.5772/intechopen.100337

Fred Chasalow

引用次数: 1

Role of Vitamin D in Preeclampsia 维生素D在子痫前期的作用

Preeclampsia [Working Title] Pub Date : 2021-10-03 DOI: 10.5772/intechopen.100139

S. Kharb

引用次数: 0