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Secretion and Signalling of extracellular vesicles最新文献

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EVs in the retina: Shining light on extracellular vesicles 视网膜中的EVs:照射在细胞外囊泡上
Secretion and Signalling of extracellular vesicles Pub Date : 2023-08-29 DOI: 10.47184/tev.2023.01.05
K. Wunderlich
{"title":"EVs in the retina: Shining light on extracellular vesicles","authors":"K. Wunderlich","doi":"10.47184/tev.2023.01.05","DOIUrl":"https://doi.org/10.47184/tev.2023.01.05","url":null,"abstract":"The present review presents the current knowledge on extracellular vesicle biology in the retina, a highly structured part of the central nervous system that is at the same time easily accessible. Numbers of publications in the field are rapidly rising, but most studies focus on extracellular vesicles as biomarkers for retinal diseases or as putative therapeutic targets. However, rather little has been done so far to elucidate the physiological functions of EVs in the retina. Even though it is clear that all the characteristic functions of EVs such as cell-cell communication, waste removal, extracellular matrix turnover, immune modulation etc. are of extreme importance in retinal tissue with its enormous metabolic turn-over and the need to orchestrate broad adaptation to different conditions such as light and dark with as little disturbance of the light path as possible.","PeriodicalId":362273,"journal":{"name":"Secretion and Signalling of extracellular vesicles","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122917284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Kinesin-mediated transport in the secretion of extracellular vesicles 胞外囊泡分泌中运动蛋白介导的运输
Secretion and Signalling of extracellular vesicles Pub Date : 2023-08-29 DOI: 10.47184/tev.2023.01.06
J. Gross, Henrike Tietz
{"title":"Kinesin-mediated transport in the secretion of extracellular vesicles","authors":"J. Gross, Henrike Tietz","doi":"10.47184/tev.2023.01.06","DOIUrl":"https://doi.org/10.47184/tev.2023.01.06","url":null,"abstract":"The secretion of small extracellular vesicles (EVs) plays a crucial role in intercellular communication and cellular homeostasis. However, there are still many unanswered questions regarding the transport processes within the endosomal system that lead to the generation and secretion of small EVs. This review will specifically address the transport of endocytic vesicles throughout the cell and the involvement of motor proteins, particularly kinesins, in the transport of endosomal compartments destined for the secretion of EVs.","PeriodicalId":362273,"journal":{"name":"Secretion and Signalling of extracellular vesicles","volume":"64 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129817612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
EVs from primary neurons: Characterization of extracellular vesicles derived from mouse primary neurons 来自原代神经元的ev:小鼠原代神经元细胞外囊泡的表征
Secretion and Signalling of extracellular vesicles Pub Date : 2023-08-29 DOI: 10.47184/tev.2023.01.03
Loic Auderset, A. Antoniou
{"title":"EVs from primary neurons: Characterization of extracellular vesicles derived from mouse primary neurons","authors":"Loic Auderset, A. Antoniou","doi":"10.47184/tev.2023.01.03","DOIUrl":"https://doi.org/10.47184/tev.2023.01.03","url":null,"abstract":"It is now clear that the specific composition of extracellular vesicles (EV) is largely determined by the type and developmental or biological state of their donor cells. Careful characterization of EV secretion is therefore important for understanding their functions in specific contexts. Here, we assess neuronal EV secretion, using mouse primary cortical and hippocampal neurons and at two developmental stages. Our proteomics data further shows the presence of widely reported EV proteins such as CD81, Alix and TSG101, and the absence of the commonly used EV marker CD63. Moreover, neuron-derived EVs were significantly enriched in neuronal-enriched proteins, including specific synaptic proteins. Overall, this data provides an initial framework for the isolation of EVs from primary neurons that could be beneficial for specific studies of neuron-derived EVs.","PeriodicalId":362273,"journal":{"name":"Secretion and Signalling of extracellular vesicles","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128888884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Extracellular vesicles and Wnt signaling: New implications for cancer research 细胞外囊泡和Wnt信号:癌症研究的新意义
Secretion and Signalling of extracellular vesicles Pub Date : 2023-08-29 DOI: 10.47184/tev.2023.01.04
Kerstin Menck, Allegra Angenendt, Katharina Maria Richter
{"title":"Extracellular vesicles and Wnt signaling: New implications for cancer research","authors":"Kerstin Menck, Allegra Angenendt, Katharina Maria Richter","doi":"10.47184/tev.2023.01.04","DOIUrl":"https://doi.org/10.47184/tev.2023.01.04","url":null,"abstract":"Extracellular vesicles (EVs) have emerged as important players in intercellular communication, capable of transferring signaling molecules between cells and altering their behavior and function. More and more studies reveal an association of factors of the Wnt pathway with EVs. A tight and coordinated regulation of Wnt signaling is essential for maintaining tissue homeostasis, and dysregulation has been associated with several diseases, including cancer. The influence of Wnt signaling on EV biogenesis has revealed a new mechanism by which Wnt proteins can regulate the creation of a favorable tumor microenvironment promoting the growth and survival of cancer cells. This review summarizes our current understanding of the connections between EVs and Wnt signaling and discusses their relevance in human cancer.","PeriodicalId":362273,"journal":{"name":"Secretion and Signalling of extracellular vesicles","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122744135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Results of the first GSEV survey in Germany 德国首次GSEV调查结果
Secretion and Signalling of extracellular vesicles Pub Date : 2023-08-29 DOI: 10.47184/tev.2023.01.01
Kerstin Menck
{"title":"Results of the first GSEV survey in Germany","authors":"Kerstin Menck","doi":"10.47184/tev.2023.01.01","DOIUrl":"https://doi.org/10.47184/tev.2023.01.01","url":null,"abstract":"Research on extracellular vesicles is on the rise, world-wide and also in Germany. This report summarizes the main findings of the first online survey that was conducted by the German Society for Extracellular Vesicles (GSEV). The eleven questions were aimed at identifying research topics of interest and ideas for future developments of GSEV.","PeriodicalId":362273,"journal":{"name":"Secretion and Signalling of extracellular vesicles","volume":"50 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132553693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New EV nucleus in northern Germany - The Hamburg EV community: A present reality with a promising future 德国北部的新电动汽车核心-汉堡电动汽车社区:一个有希望的未来的现实
Secretion and Signalling of extracellular vesicles Pub Date : 2023-08-29 DOI: 10.47184/tev.2023.01.02
Andreu Matamoros-Angles, Santra Brenna, Karen Lahme, F. Braun, M. Dandri, B. Puig
{"title":"New EV nucleus in northern Germany - The Hamburg EV community: A present reality with a promising future","authors":"Andreu Matamoros-Angles, Santra Brenna, Karen Lahme, F. Braun, M. Dandri, B. Puig","doi":"10.47184/tev.2023.01.02","DOIUrl":"https://doi.org/10.47184/tev.2023.01.02","url":null,"abstract":"On April 13-14th, 2023, more than 50 researchers located in Hamburg, mainly working at the University Medical Center Hamburg-Eppendorf (UKE), met to present research projects focusing on extracellular vesicles (EVs). The meeting was supported by State Research Funding (LFF-FV74: Mechanisms of cell communication in Infection; Speaker Maura Dandri, UKE), which aims to develop existing and promising research areas further. This meeting certainly surpassed all expectations: what was first organized as a tentative get-together between a dozen EV scientists, soon revealed the existence of a much broader and strong EV community with more than 50 basic researchers and clinicians currently active in Hamburg. This first UKE-EV meeting created a platform to share experiences, projects, and protocols and mainly discuss future requirements to create a consolidated structure and network in Hamburg, enabling state-of-the-art EV research.","PeriodicalId":362273,"journal":{"name":"Secretion and Signalling of extracellular vesicles","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126420647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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