SOJ Neurology and Neuroscience最新文献

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Neuroscience 神经科学
SOJ Neurology and Neuroscience Pub Date : 1900-01-01 DOI: 10.53902/sojnn.2022.02.000508
Gilson de Abreu Viza Junior
{"title":"Neuroscience","authors":"Gilson de Abreu Viza Junior","doi":"10.53902/sojnn.2022.02.000508","DOIUrl":"https://doi.org/10.53902/sojnn.2022.02.000508","url":null,"abstract":"Infectious diseases take time to show clinical signs. The most common is to present a dysfunction of the target organ, that is, if the infection is in the neural system the most common sign is headache, if the infection is pulmonary the most common symptom is cough, if the infection is in gastrointestinal tract, diarrhea. However, there are more general signs such as fever, in appetence and dynamic, which are generalized manifestations that reflect that the organ system is experiencing an infection. There are complementary tests that help in the correct diagnosis of these infections.","PeriodicalId":350784,"journal":{"name":"SOJ Neurology and Neuroscience","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122534375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Covid-19, Carnosine and Cognition Covid-19、肌肽与认知
SOJ Neurology and Neuroscience Pub Date : 1900-01-01 DOI: 10.53902/sojnn.2021.01.000506
A. Hipkiss
{"title":"Covid-19, Carnosine and Cognition","authors":"A. Hipkiss","doi":"10.53902/sojnn.2021.01.000506","DOIUrl":"https://doi.org/10.53902/sojnn.2021.01.000506","url":null,"abstract":"The possible ameliorative roles of the dipeptide carnosine with respect to Covid-19 viral infection and associated pathologies are discussed. In particular carnosine’s ability to suppress age-related changes in carbohydrate metabolism which normally exacerbate Covid-19-induced dysfunction as well as the dipeptide’s anti-inflammatory activity is considered. As carnosine is normally present in the olfactory lobe and that anosmia (loss of sense of smell) is a common feature of Covid-19’s effect on humans, the possibility that nasal administration of carnosine could be therapeutic is considered as a means of raising levels of the dipeptide in the olfactory lobe and thereby alleviates virus-mediated neuropathology.","PeriodicalId":350784,"journal":{"name":"SOJ Neurology and Neuroscience","volume":"82 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114503584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Role of Mutations on Genes KRT3 & KRT12 in Meesmann Corneal Dystrophy Syndrome KRT3和KRT12基因突变在Meesmann角膜营养不良综合征中的作用
SOJ Neurology and Neuroscience Pub Date : 1900-01-01 DOI: 10.53902/sojnn.2022.02.000509
S. Asadi
{"title":"The Role of Mutations on Genes KRT3 & KRT12 in Meesmann Corneal Dystrophy Syndrome","authors":"S. Asadi","doi":"10.53902/sojnn.2022.02.000509","DOIUrl":"https://doi.org/10.53902/sojnn.2022.02.000509","url":null,"abstract":"Meesmann corneal dystrophy syndrome is a genetic disorder of the eye that affects the cornea. This condition is characterized by the formation of small round cysts in all parts of the corneal layer, called the corneal epithelium. Meesmann corneal dystrophy syndrome is caused by a mutation in the KRT12 gene, which is located in the long arm of chromosome 17 as 17q21.2, or the KRT3 gene, which is located in the long arm of chromosome 12, as 12q13.13.","PeriodicalId":350784,"journal":{"name":"SOJ Neurology and Neuroscience","volume":"35 16","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114028321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dementia in Parkinson’s Disease: it’s Therapeutics 帕金森病中的痴呆:治疗学
SOJ Neurology and Neuroscience Pub Date : 1900-01-01 DOI: 10.53902/sojnn.2021.01.000501
A. Chakraborty
{"title":"Dementia in Parkinson’s Disease: it’s Therapeutics","authors":"A. Chakraborty","doi":"10.53902/sojnn.2021.01.000501","DOIUrl":"https://doi.org/10.53902/sojnn.2021.01.000501","url":null,"abstract":"Background: Dementia is a cognitive degenerative disease generally associated with Alzheimer disease, but victims with Parkinson’s disease also develops dementia at the latter stage. Dementia associates with irreversible loss of memory, and no medicinal cure is yet available. We here put some light on possible cell therapy for dementia. Aim: Neural stem cells are multipotent cells which are capable of self-replication and differentiation into neurons, astrocytes or oligodendrocytes in the central nervous system. They produce Dopamine, neural factors, and therefore, one can expect that NSC transplantation can ultimately provide a better therapeutic approach in the treatment of dementia as well as Parkinson’s disease (PD). Methods: We discussed the merits and demerits of using hNSCs cells over other possible candidate cells. Results: As we found that hNSCs can secrete Dopamine as well as some neurotropic factors, like Brain-Derived Neurotropic Factor (BDNF) and Glial cell-Derived Neurotropic Factors (GDNF) which can support the proliferation of hNSCS and its Dopamine production ability, hNSCs can supply dopamine and also can stop α-synuclein aggregation. Conclusion: hNSCs, therefore, could be a better cell regiment for cell transplantation therapy for dementia as well as PD.","PeriodicalId":350784,"journal":{"name":"SOJ Neurology and Neuroscience","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132831265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Simplified Overview of the Current Non-Surgical Treatment of Brain Tumor Patients with Special Emphasis on Its Complications. A Much Needed Contemporary Review Especially for Neurosurgeons 目前脑肿瘤非手术治疗的简单概述,特别强调其并发症。一个非常需要的当代评论,特别是对神经外科医生
SOJ Neurology and Neuroscience Pub Date : 1900-01-01 DOI: 10.53902/sojnn.2021.01.000507
A. Chaturbedi
{"title":"A Simplified Overview of the Current Non-Surgical Treatment of Brain Tumor Patients with Special Emphasis on Its Complications. A Much Needed Contemporary Review Especially for Neurosurgeons","authors":"A. Chaturbedi","doi":"10.53902/sojnn.2021.01.000507","DOIUrl":"https://doi.org/10.53902/sojnn.2021.01.000507","url":null,"abstract":"Brain tumors are complex entities with facts as numerous as stars in our sky, uncountable. They exist and thus every treating physician and surgeon happens to come across it. We try to put major contemporary practices and facts in a single bucket from learned skills of neurology and oncology tradition and things we received as feedback from our patients in clinical settings. Purpose of this work is to refresh your knowledge and preparedness for seeing patients with brain cancer. Brain tumors are molecularly heterogeneous and their features depend upon size, site, and genetic make-up of tumor, aggressive growth, and adjacent structures. Complications and their management are very challenging. This article will comfortably sail you through various aspects of management of brain cancers.","PeriodicalId":350784,"journal":{"name":"SOJ Neurology and Neuroscience","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133498979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Significance of Cortical Micro-Infarcts in the Human Brain 人脑皮层微梗死的意义
SOJ Neurology and Neuroscience Pub Date : 1900-01-01 DOI: 10.53902/sojnn.2021.01.000503
J. De Reuck
{"title":"Significance of Cortical Micro-Infarcts in the Human Brain","authors":"J. De Reuck","doi":"10.53902/sojnn.2021.01.000503","DOIUrl":"https://doi.org/10.53902/sojnn.2021.01.000503","url":null,"abstract":"Cortical micro-infarcts are due to cerebral small vessel disease. In contrast to the arteriosclerotic type of cerebral small vessel disease, cortical micro-infarcts are mainly related and due to cerebral amyloid angiopathy. Alzheimer’s disease is the most frequent neurodegenerative dementia disease associated to cerebral amyloid angiopathy and cortical micro-infarcts. Vascular dementia cannot only be due to lacunar infarcts and ischemic white matter changes, but can also be caused by cortical micro-infarcts. The latter are a frequent cause of vascular dementia and decrease globally the cerebral blood flow.","PeriodicalId":350784,"journal":{"name":"SOJ Neurology and Neuroscience","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127795553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of Patient Centred Care in a Dementia Ward in an Acute Hospital 以病人为中心的护理在急性痴呆病房的影响
SOJ Neurology and Neuroscience Pub Date : 1900-01-01 DOI: 10.53902/sojnn.2021.01.000502
L. Ching
{"title":"Impact of Patient Centred Care in a Dementia Ward in an Acute Hospital","authors":"L. Ching","doi":"10.53902/sojnn.2021.01.000502","DOIUrl":"https://doi.org/10.53902/sojnn.2021.01.000502","url":null,"abstract":"The older persons with dementia will occupy more hospital beds in the years to come. Caring for a patient living with dementia is challenging for the hospital staff, especially for those exhibiting neuropsychiatric symptoms. Providing person centred care has been recognised as the ideal model of care for the persons with dementia. However, this care model is time consuming and requires training and education. Provision of good care in the hospital for the older persons with dementia include avoidance of restraints, prescription of psychotropics, in-hospital fall reduction, minimising risk of cognitive and functional decline with discharge home to their families and loved ones.Person centred care is effective in the acute setting,with proper training, guidance and leadership.","PeriodicalId":350784,"journal":{"name":"SOJ Neurology and Neuroscience","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124776149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The 30 Top-Cited Articles on Os Odontoideum: A Bibliometric Study Odontoideum的30篇被引文章:文献计量学研究
SOJ Neurology and Neuroscience Pub Date : 1900-01-01 DOI: 10.53902/sojnn.2021.01.000504
Weixin Li
{"title":"The 30 Top-Cited Articles on Os Odontoideum: A Bibliometric Study","authors":"Weixin Li","doi":"10.53902/sojnn.2021.01.000504","DOIUrl":"https://doi.org/10.53902/sojnn.2021.01.000504","url":null,"abstract":"Objective: To evaluate the top 30 most-cited articles in the literature on os odontoideum. Methods: A search using the Web of Science database and the search phrase \"os odontoideum\" was conducted. The 30 most-cited articles on osodontoideum were analyzed. The study was performed in May 2020. We searched for articles published between 1920 and 2020. Articles were sorted and ranked according to the total number of citations. We evaluated the following information of each article, including first author, journal, title, number of citations, average citation per year, and author affiliation. Results: A total of 357 studies matched our search criteria, of which the top 30 most-cited ranged between 232 and 60 citations. The article by Dickman et al. published in Neurosurgery, was the most-cited article with a total citation of 232, followed by Dickman et al. with 221 and Smoker et al. with 179. Menezes was the most cited first authors, with 4 articles, followed by Dickman with 3 articles. Child's Nervous System, Journal of Neurosurgery, and Spine were three most frequent destination journals. Most of the articles originated from the United States (n=24) and University of Iowa Hospitals and Clinics published 6 articles and was the highest in the number of most-cited articles. Most of the articles focused on the clinical management of osodontoideum (83.3%). Conclusion: The current study confers a better understanding of current treatment strategies and the advances in the management of osodontoideum. It helps guide the clinical management and academic achievements.","PeriodicalId":350784,"journal":{"name":"SOJ Neurology and Neuroscience","volume":"128 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128107474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Paranoid Hostility but Not Depressive Symptoms Associated with Cytokines During the Premenstrual Phase in Young Women 年轻女性经前期偏执敌意而非抑郁症状与细胞因子相关
SOJ Neurology and Neuroscience Pub Date : 1900-01-01 DOI: 10.53902/sojnn.2021.01.000505
Syros Ioannis
{"title":"Paranoid Hostility but Not Depressive Symptoms Associated with Cytokines During the Premenstrual Phase in Young Women","authors":"Syros Ioannis","doi":"10.53902/sojnn.2021.01.000505","DOIUrl":"https://doi.org/10.53902/sojnn.2021.01.000505","url":null,"abstract":"It is well known that some women, during their premenstrual phase, express Hostility (Ho) and Depressive symptoms (De). Various studies indicate that Ho and De correlate with circulating concentrations of cytokines. These data support the hypothesis of an inflammation-sensitive mechanism linked to certain psychological states. The aim of this study was to correlate Ho and De with selective proinflammatory cytokines during the menstrual cycle in young women. Twenty-two physically healthy medical students, mean age 22.95+2.83(SD), were studied. All reported regular menses that ranged between 27-33 days. Blood was drawn three times across a single cycle: at follicular phase (FL), at mid luteal phase (ML) and at late luteal phase (LL) corresponding to the premenstrual phase. The following proinflammatory cytokines were determined at each sample: Interleukin 8 (IL-8), Interleukin 6 (IL-6), Interleukin 1α (IL-1α), and Tumor Necrosis Factor-α (TNF-α). Immediately before blood sampling the women completed the Zung self-rating depression scale and the hostility and direction of hostility questionnaire (HDHQ), which comprises five subscales: urge to act out hostility, criticism of others, paranoid hostility, self-criticism and delusional guilt. Spearman’s rank correlation was used to determine the relation between variables at the specific time points; ρ<0.05 was considered significant. Mean values of cytokines did not change significantly throughout the menstrual cycle. Paranoid hostility was positively correlated with IL-8 (Rs=0.476, p=0.046), IL-1α (Rs=0.458, p=0.048) and TNF-α (Rs=0.518, p=0.023) in LLphase. No other significant correlation was found. Cytokines correlate with paranoid hostility and this correlation is probably related with the premenstrual hormonal changes. It is difficult to evaluate the clinical significance of our findings, nevertheless, when exploring the above association, it is necessary to take into consideration the phase of the cycle as well as the special aspects of Ho we seek to study.","PeriodicalId":350784,"journal":{"name":"SOJ Neurology and Neuroscience","volume":"54 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126854258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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