Journal of Health Policy Outcomes Research最新文献

{"title":"Social/ economic burden and health-related quality of life in patients with Spinal Muscular Atrophy (SMA) in Greece","authors":"Vasileios Kontogiannis, Marios Athanasios Loupas, Mary Adamopoulou, Dimitris Athanasiou, Georgia Moraiti, Jan Traeger-Synodinos, Chrystallena Sofocleous, Kyriaki Kekou, Maria Kalogeropoulou","doi":"10.7365/jhpor.2023.2.6","DOIUrl":"https://doi.org/10.7365/jhpor.2023.2.6","url":null,"abstract":"Objective: The objective of this study was to determine the economic burden and health-related quality of life (HRQoL) of patients with SMA and their caregivers in Greece, which is still unknown, and explore the economic impact of the implementation of a reproductive carrier screening (RCS) program. Methods: A cross-sectional study was conducted in which an online questionnaire was completed by caregivers of SMA patients. A cost of illness (COI) model was developed in which costs per patient were calculated from a societal perspective and extrapolated to the Greek SMA population. Parents’/caregivers’ HRQoL was measured using the 36-item PedsQL™ Family Impact Module. Resources for the implementation of RCS program were estimated and its short-term impact was assessed. Results: The COI was estimated at €261,785 per patient in 2022. When extrapolating this across all affected persons, the average annual cost ranged from €49,739,395 to €91,036,017 depending on the prevalence considered. Out-of-pocket expenses accounted for 8% of the total. Results of the analysis on HRQoL indicated a high burden on parents/ caregivers with the majority of scores falling below 50 and a mean total score of 45. Depending on the scenario used, an RCS program could save the Greek healthcare system at least €167,181 or increase its costs by €564,804. Conclusions: SMA imposes a significant economic burden in affected patients, caregivers, and health care system. The cost-saving magnitude of a potential implementation of a CRS program is dependent on the parents' reproductive choices following a positive screening result.","PeriodicalId":34684,"journal":{"name":"Journal of Health Policy Outcomes Research","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135222496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How does the method of formulation a drug affect its efficacy and safety, based on the comparison of modified and conventional release amantadine in the treatment of levodopa induced dyskinesia in patients with Parkinson's disease?","authors":"Marzena Jaworska","doi":"10.7365/jhpor.2023.2.5","DOIUrl":"https://doi.org/10.7365/jhpor.2023.2.5","url":null,"abstract":"Background The choice of the appropriate method of drug production is determined mainly by the characteristics of the medicinal substances and excipients, the type of disease in which the drug is to be used and the expectations of patients. The appropriate method of drug production may be key importance for achieving clinically significant treatment effects. For this reason, an attempt has been made to evaluate modified and conventional release forms of amantadine for the treatment of levodopa-induced dyskinesias in patients with Parkinosn's disease. Methods The effect of two different forms of amantadine on the treatment of levodopa - induced dyskinesias in patients with Parkinson's disease was assessed through a systematic review of clinical trials following the PICOS regimen. The clinical efficacy of the treatment of levodopa-induced dyskinesias in patients with Parkinson's disease was assessed by a measure of the appropriate scale and the effect on the ON and OFF times. Results Although no studies were found directly comparing the use of amantadine ER with amantadine IR in this disease, in the studies of amantadine ER, the UDysRS score showed a significantly greater improvement in the treatment of dyskinesia in the study group compared to placebo. The amantadine IR studies did not show any significant effect on the treatment effects. Conclusions The choice of the method of producing a drug has a significant impact on the effects of treatment.","PeriodicalId":34684,"journal":{"name":"Journal of Health Policy Outcomes Research","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135197961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Barriers to Utilization of Postnatal Care Services within the First 48 Hours of Birth in North West Syria: A Barrier Analysis Study","authors":"Ismail Alkhatib, Nimetcan Mehmet","doi":"10.7365/jhpor.2023.2.4","DOIUrl":"https://doi.org/10.7365/jhpor.2023.2.4","url":null,"abstract":"Objectives: The objective of this study is to identify barriers to the utilization of postnatal care services among mothers and neonates in a conflict-affected area. Methods: This study involves a cross-sectional survey utilizing the Barrier Analysis (BA) approach, which is based on the Health Belief Model and the Theory of Reasoned Action. It explores up to 12 recognized determinants of behavior adoption. The survey was conducted in six communities located in Idlib and western rural Aleppo, representing both urban and rural areas for host and displaced populations in northwest Syria (Selwa, Abin Samaan, Sahara, Tal Elkaramej, Boz Ghaz, Koknaya). Data collection took place from 7th to 11th November 2021. Initially, screening questions were used to verify participants' eligibility for the survey. The interviewed mothers were then classified into two main groups: the first group consisted of mothers of newborns who attended postnatal care within the first 48 hours after birth (DOERS), while the second group comprised mothers of newborns who did not attend postnatal care within the first 48 hours after birth (NON-DOERS). From both groups, a random sample of 90 mothers of newborns aged 0-6 months was selected (45 DOERS and 45 NON-DOERS) out of a total of 418 respondents. Their answers were analyzed based on the 12 determinants included in the questionnaire. All collected data, including coded qualitative data and closed-ended questions, along with their frequencies, were entered into the Standard Barrier Analysis Tabulation Sheet Excel (SBATS). The odds ratio and P-value were calculated, considering results to be \"significant\" if the P-value was less than 0.05. Results: All demonstrated significant results are being compared between doers (mothers who attend postnatal care within the first 48 hours after birth) and non-doers (mothers who did not attend postnatal care within the first 48 hours after birth) according to the determinants and based on their recurrence, not their percentage. A total of 90 mothers with newborns aged 0-6 months (45 DOERS and 45 NON-DOERS) were interviewed, the findings revealed that 68% of the interviewed mothers had a normal delivery at health facilities, while 20% had a cesarean delivery, and 12% had a normal delivery at home. The barriers to PNC services included the long distance of the health facilities and the absence of transportation, social norms and traditions that prevent women from leaving home after childbirth, overcrowding at health facilities, fear of COVID-19 infection when visiting health facilities, absence of accompanying people, and the perception among mothers that they were unlikely to experience immediate post-birth problems. On the other hand, the enablers for accessing postnatal care services included community-based health support through community health workers, awareness of the available services, the mother's level of education, and a perceived understanding of the risks associated with medical","PeriodicalId":34684,"journal":{"name":"Journal of Health Policy Outcomes Research","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135878083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}