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Reproductive Hormones最新文献

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Androgens’ Effects across the Lifespan in Men and Animal Models 男性和动物模型中雄激素在整个生命周期中的作用
Reproductive Hormones Pub Date : 2021-04-14 DOI: 10.5772/INTECHOPEN.96707
C. Frye, Jennifer K. Torgersen, Vincent F. Lembo, K. Drew
{"title":"Androgens’ Effects across the Lifespan in Men and Animal Models","authors":"C. Frye, Jennifer K. Torgersen, Vincent F. Lembo, K. Drew","doi":"10.5772/INTECHOPEN.96707","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.96707","url":null,"abstract":"The clinical literature and recent studies in our laboratory using rodent models demonstrate that there are individual differences in androgens’ pleiotropic effects across the lifespan that need to be better understood. The question to address that challenges the field is that levels of androgens (current and/or prior) may not drive differing responses to androgens. The clinical example of Post-finasteride Syndrome, in which side-effects persist long after treatment is discontinued, supports investigations of this novel question relating to long-term effects of androgen manipulations, independent of existing levels of androgens.","PeriodicalId":344764,"journal":{"name":"Reproductive Hormones","volume":"52 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133505806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nociceptive TRP Channels and Sex Steroids 痛觉性TRP通道与性类固醇
Reproductive Hormones Pub Date : 2021-03-24 DOI: 10.5772/INTECHOPEN.95552
Óscar Enciso-Pablo, K. A. Méndez-Reséndiz, T. Rosenbaum, S. Morales-Lázaro
{"title":"Nociceptive TRP Channels and Sex Steroids","authors":"Óscar Enciso-Pablo, K. A. Méndez-Reséndiz, T. Rosenbaum, S. Morales-Lázaro","doi":"10.5772/INTECHOPEN.95552","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.95552","url":null,"abstract":"Proteins belonging to Transient Receptor Potential (TRP) family are nonselective cation channels that play an essential role in mammalian physiology, functioning as transducers of several environmental signals including those of chemical, thermal and mechanical natures. A subgroup of these receptors is expressed in sensory neurons where they are activated by noxious stimuli and are key players of pain responses in the organism. Some TRP channels are molecular targets for the classical and non-classical effects of sex steroids. This chapter will describe the close relationship between nociceptive TRP channels and sex steroids as well as their impact on nociception and pain-related responses.","PeriodicalId":344764,"journal":{"name":"Reproductive Hormones","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123668230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Kisspeptin: Role in Female Infertility Kisspeptin:在女性不育中的作用
Reproductive Hormones Pub Date : 2020-11-23 DOI: 10.5772/intechopen.94925
A. Kükürt, M. Kuru, Ömer Başer, M. Karapehlivan
{"title":"Kisspeptin: Role in Female Infertility","authors":"A. Kükürt, M. Kuru, Ömer Başer, M. Karapehlivan","doi":"10.5772/intechopen.94925","DOIUrl":"https://doi.org/10.5772/intechopen.94925","url":null,"abstract":"Kisspeptin is a neuropeptide encoded by the kisspeptin gene (Kiss1) and located in different brain regions, primarily in the hypothalamus. Kisspeptin and its receptor G-protein-coupled receptor-54 (GPR54), are also found in behavioural brain regions such as the hippocampus and cortex. Kisspeptin, a very powerful neuropeptide that stimulates the secretion of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary, does this by increasing gonadotropin-releasing hormone (GnRH) levels. In recent studies, it has been noted that kisspeptin is effective on reproductive functions. Globally 8 to 12% of couples have infertility problems, and the majority are residents of developing countries. Approximately 70% of infertility cases are caused by fertility problems in women. The frequency of infertility in women continues to increase every year and the underlying factors require further research. Bearing this problem in mind, this review examines the possible role of kisspeptin in female infertility. In doing so, it aims to find out how future application of kisspeptin may potentially unravel the neural reproductive disorder.","PeriodicalId":344764,"journal":{"name":"Reproductive Hormones","volume":"8 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132501884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
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