Gastroesophageal Reflux Disease - Theory and Research最新文献

Clinical Picture of Gastroesophageal Reflux Disease in Children 儿童胃食管反流病的临床表现

Gastroesophageal Reflux Disease - Theory and Research Pub Date : 2019-04-03 DOI: 10.5772/INTECHOPEN.82453

P. Quitadamo, A. Staiano

{"title":"Clinical Picture of Gastroesophageal Reflux Disease in Children","authors":"P. Quitadamo, A. Staiano","doi":"10.5772/INTECHOPEN.82453","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.82453","url":null,"abstract":"Gastroesophageal reflux (GER), defined as the passage of gastric contents into the esophagus, is a normal physiologic process occurring several times per day in healthy infants, children, and adults. The majority of GER episodes occur in the postprandial period, last in <3 min, and cause few or no symptoms. Conversely, when the reflux of gastric contents into the esophagus causes troublesome symptoms and/or complications, we talk about “gastroesophageal reflux disease (GERD).” Distinguishing physiologic GER from GERD may often be tricky for clinicians, especially in infants. The typical presentation of GERD includes the following symptoms: recurrent regurgitation, vomiting, weight loss or poor weight gain, excessive crying and irritability in infants, heartburn or chest pain, ruminative behavior, hematemesis, and dysphagia. Besides these esophageal symptoms, there is a set of extra-esophageal symptoms, mainly respiratory, which may occur along with typical symptoms or may represent the only clinical picture of GERD: odynophagia, wheezing, stridor, cough, hoarse-ness, dental erosions, and apnea/apparent life-threatening events (ALTEs). While infantile GER tends to resolve spontaneously and does not deserve pharmacological treatment, GERD management includes lifestyle changes, pharmacologic therapy, and surgery. Therefore, a proper diagnosis of these two conditions, besides other possible conditions mimicking reflux, is crucial in order to target the treatment, avoiding the overuse of antacid drugs that currently represents a major source of concern.","PeriodicalId":344241,"journal":{"name":"Gastroesophageal Reflux Disease - Theory and Research","volume":"95 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114503509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Introductory Chapter: Gastroesophageal Reflux Disease 导论:胃食管反流病

Gastroesophageal Reflux Disease - Theory and Research Pub Date : 2019-04-03 DOI: 10.5772/INTECHOPEN.84879

A. Yahya

引用次数: 0

The Role of Increased Gastric Acid Secretion and Reactive Oxygen Species in the Pathophysiology of Reflux Esophagitis 胃酸分泌增加和活性氧在反流性食管炎病理生理中的作用

Gastroesophageal Reflux Disease - Theory and Research Pub Date : 2019-04-03 DOI: 10.5772/INTECHOPEN.81021

Mohamed-Amine Jabri, H. Sebai

引用次数: 0

Refractory Gastroesophageal Reflux Disease (GERD) Symptoms 难治性胃食管反流病(GERD)症状

Gastroesophageal Reflux Disease - Theory and Research Pub Date : 2018-12-19 DOI: 10.5772/INTECHOPEN.80792

Xia Chen, Fei Wang

{"title":"Refractory Gastroesophageal Reflux Disease (GERD) Symptoms","authors":"Xia Chen, Fei Wang","doi":"10.5772/INTECHOPEN.80792","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.80792","url":null,"abstract":"Gastroesophageal reflux disease (GERD) is a chronic condition in which patients suffer troublesome symptoms and/or complications as the reflux of stomach contents occurs. GERD is a common disease worldwide with the range of estimated prevalence 18.1–27.8% in North America, 8.8–25.9% in Europe, 2.5–7.8% in East Asia, 8.7–33.1% in the Middle East, 11.6% in Australia and 23.0% in South America. It causes significant morbidity, considerable decrease of quality of life and high costs of exams and treatment derived from repeated visit doctor. The patients with GERD suffer from typical symptoms such as heartburn and regurgitation, as well as other atypical symptoms including chest pain, cough, asthma, and hoarseness. With the usage of pump inhibitors (PPIs) in clinic, a dramatic improvement in symptom resolution and life quality, as well as in mucosal healing is expected. However, the treatment of GERD fails in a proportion of patients despite the high efficacy of PPIs. This situation is getting more and more common in clinical practices. In this chapter, we will discuss about this difficult situation, emphasizing diagnosis and treatment, combined with suggested management of these patients.","PeriodicalId":344241,"journal":{"name":"Gastroesophageal Reflux Disease - Theory and Research","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134231028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Challenges to Unravel Mechanisms of GERD 揭示GERD机制的挑战

Gastroesophageal Reflux Disease - Theory and Research Pub Date : 2018-11-05 DOI: 10.5772/INTECHOPEN.80793

S. Shimoyama

引用次数: 0