发布求助
文献互助 智能选刊 最新文献

Zhurnal organichnoyi ta farmatsevtichnoyi khimiyi最新文献

筛选
英文 中文
Development and validation of the HPLC-procedure for the quantitative determination of isosorbide dinitrate in matrix granules 高效液相色谱法测定基质颗粒中硝酸异山梨酯含量的建立与验证
Zhurnal organichnoyi ta farmatsevtichnoyi khimiyi Pub Date : 2019-09-03 DOI: 10.24959/ophcj.19.174771
D. Oleynikov, A. Kaplaushenko
{"title":"Development and validation of the HPLC-procedure for the quantitative determination of isosorbide dinitrate in matrix granules","authors":"D. Oleynikov, A. Kaplaushenko","doi":"10.24959/ophcj.19.174771","DOIUrl":"https://doi.org/10.24959/ophcj.19.174771","url":null,"abstract":"Isosorbide dinitrate is a universally recognized drug for the relief of angina attacks. Today, prolonged forms of isosorbide dinitrate are of great interest due to their high antianginal efficacy and lower frequency of side effects that are characteristic for drugs with immediate release. Aim. To develop the procedure for the quantitative determination of isosorbide dinitrate in matrix granules using high performance liquid chromatography and validate it. Results. To determine isosorbide dinitrate by the method of high performance liquid chromatography with UV-detection the optimal chromatographic conditions were selected taking into account the effect of excipients in the composition of the medicine. To prove the possibility of applying the procedure proposed in the further analysis of matrix granules of isosorbide dinitrate its validation was carried out. Such validation parameters as specificity, linearity, repeatability, accuracy, intermediate precision, limit of detection and limit of quantification, robustness were assessed using model solutions. Experimental part. The chromatographic researches were performed using liquid chromatograph Shimadzu LC-20AD XR with diode-array detector under the following conditions: chromatographic column – Supelco Discovery C18 (150 × 4.6 мм, 5 мкм); mobile phase – water R – buffer solution with (pH 4.7) – methanol R2 (35:10:55); elution mode – isocratic; flow rate of the mobile phase – 1.0 mL/min.; detection wavelength –220 nm; software – LCsolution, 1.24.SP.1 version. Conclusions. A new procedure for the quantitative determination of isosorbide dinitrate in matrix granules has been developed using high performance liquid chromatography. Its validation has been carried out, and its acceptability has been proven.","PeriodicalId":34252,"journal":{"name":"Zhurnal organichnoyi ta farmatsevtichnoyi khimiyi","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69135330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Development and validation of the enzymatic kinetic photometric procedure for determination of residual quantities of dequalinium chloride on the surface of the pharmaceutical equipment 开发和验证用于测定制药设备表面氯去qualinium残留量的酶动力学光度法程序
Zhurnal organichnoyi ta farmatsevtichnoyi khimiyi Pub Date : 2019-08-28 DOI: 10.24959/ophcj.19.175500
M. Blazheyevskiy, O. Koval’ska, Ye. O. Tsapko, D. Shapovalenko
{"title":"Development and validation of the enzymatic kinetic photometric procedure for determination of residual quantities of dequalinium chloride on the surface of the pharmaceutical equipment","authors":"M. Blazheyevskiy, O. Koval’ska, Ye. O. Tsapko, D. Shapovalenko","doi":"10.24959/ophcj.19.175500","DOIUrl":"https://doi.org/10.24959/ophcj.19.175500","url":null,"abstract":"","PeriodicalId":34252,"journal":{"name":"Zhurnal organichnoyi ta farmatsevtichnoyi khimiyi","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48414964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The search for potential inhibitors of protein kinase Pim-1 among new amides of 1,2,4-triazolo[4,3-a]pyridine-3-metanamin with the 1,2,4-oxadiazol cycle in position 7 and 8 在1,2,4-恶二唑环位于7和8位的1,2,4-三唑并[4,3-a]吡啶-3-甲酰胺中寻找潜在的蛋白激酶Pim-1抑制剂
Zhurnal organichnoyi ta farmatsevtichnoyi khimiyi Pub Date : 2019-08-28 DOI: 10.24959/ophcj.19.174807
V. R. Karpina, S. Kovalenko, O. Zaremba, O. V. Silin, V. Ivanov, S. S. Kovalenko, T. Langer
{"title":"The search for potential inhibitors of protein kinase Pim-1 among new amides of 1,2,4-triazolo[4,3-a]pyridine-3-metanamin with the 1,2,4-oxadiazol cycle in position 7 and 8","authors":"V. R. Karpina, S. Kovalenko, O. Zaremba, O. V. Silin, V. Ivanov, S. S. Kovalenko, T. Langer","doi":"10.24959/ophcj.19.174807","DOIUrl":"https://doi.org/10.24959/ophcj.19.174807","url":null,"abstract":"","PeriodicalId":34252,"journal":{"name":"Zhurnal organichnoyi ta farmatsevtichnoyi khimiyi","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69134934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The comparative quantum chemical study of the epoxidation reaction mechanism of eugenol and isoeugenol with peracetic and perbenzoic acids 丁香酚和异丁香酚与过乙酸和过苯甲酸环氧化反应机理的比较量子化学研究
Zhurnal organichnoyi ta farmatsevtichnoyi khimiyi Pub Date : 2019-08-28 DOI: 10.24959/ophcj.19.169808
O. Agafonov, S. Okovytyy, M. Blazheyevskiy
{"title":"The comparative quantum chemical study of the epoxidation reaction mechanism of eugenol and isoeugenol with peracetic and perbenzoic acids","authors":"O. Agafonov, S. Okovytyy, M. Blazheyevskiy","doi":"10.24959/ophcj.19.169808","DOIUrl":"https://doi.org/10.24959/ophcj.19.169808","url":null,"abstract":"","PeriodicalId":34252,"journal":{"name":"Zhurnal organichnoyi ta farmatsevtichnoyi khimiyi","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69135304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis and the biological activity of bis-mefenamidocalixarene 双甲氧基氨基杯芳烃的合成及其生物活性
Zhurnal organichnoyi ta farmatsevtichnoyi khimiyi Pub Date : 2019-08-20 DOI: 10.24959/175951
N. Chalenko, R. Rodik, G. Syrova
{"title":"Synthesis and the biological activity of bis-mefenamidocalixarene","authors":"N. Chalenko, R. Rodik, G. Syrova","doi":"10.24959/175951","DOIUrl":"https://doi.org/10.24959/175951","url":null,"abstract":"","PeriodicalId":34252,"journal":{"name":"Zhurnal organichnoyi ta farmatsevtichnoyi khimiyi","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49148533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The study of the antimicrobial activity of the derivatives of 6-(1,2,4-oxadizol-3-yl)- and 6-(2-aminothiazol-4-yl)thieno[2,3-d]pyrimidin-4-ones by the double dilution method 双稀释法研究6-（1,2,4-恶二唑-3-基）-和6-（2-氨基噻唑-4-基）噻吩并[2,3-d]嘧啶-4-酮衍生物的抗菌活性
Zhurnal organichnoyi ta farmatsevtichnoyi khimiyi Pub Date : 2019-08-20 DOI: 10.24959/ophcj.19.174072
S. Vlasov, S. Kovalenko, T. Osolodchenko, V. Vlasov
{"title":"The study of the antimicrobial activity of the derivatives of 6-(1,2,4-oxadizol-3-yl)- and 6-(2-aminothiazol-4-yl)thieno[2,3-d]pyrimidin-4-ones by the double dilution method","authors":"S. Vlasov, S. Kovalenko, T. Osolodchenko, V. Vlasov","doi":"10.24959/ophcj.19.174072","DOIUrl":"https://doi.org/10.24959/ophcj.19.174072","url":null,"abstract":"","PeriodicalId":34252,"journal":{"name":"Zhurnal organichnoyi ta farmatsevtichnoyi khimiyi","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48456960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
The acid-base properties of 2-(benzoylamino)(1-R-2-oxoindolin-3-ylidene)acetic acids 2-（苯甲酰氨基）（1-R-2-氧代吲哚-3-亚基）乙酸的酸碱性质
Zhurnal organichnoyi ta farmatsevtichnoyi khimiyi Pub Date : 2019-08-20 DOI: 10.24959/ophcj.19.174801
S. Kolisnyk, O. M. Svechnikova, O. Altukhov, O. Kolisnyk, O. Vynnyk
{"title":"The acid-base properties of 2-(benzoylamino)(1-R-2-oxoindolin-3-ylidene)acetic acids","authors":"S. Kolisnyk, O. M. Svechnikova, O. Altukhov, O. Kolisnyk, O. Vynnyk","doi":"10.24959/ophcj.19.174801","DOIUrl":"https://doi.org/10.24959/ophcj.19.174801","url":null,"abstract":"","PeriodicalId":34252,"journal":{"name":"Zhurnal organichnoyi ta farmatsevtichnoyi khimiyi","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69134880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis and antioxidant properties of novel thiazolo[4,5-b]pyridine-2-ones 新型噻唑[4,5-b]吡啶-2-酮的合成及抗氧化性能
Zhurnal organichnoyi ta farmatsevtichnoyi khimiyi Pub Date : 2019-08-14 DOI: 10.24959/ophcj.19.174239
T. Chaban, Yu. E. Matiychuk, V. Ogurtsov, I. Chaban, V. Matiychuk
{"title":"Synthesis and antioxidant properties of novel thiazolo[4,5-b]pyridine-2-ones","authors":"T. Chaban, Yu. E. Matiychuk, V. Ogurtsov, I. Chaban, V. Matiychuk","doi":"10.24959/ophcj.19.174239","DOIUrl":"https://doi.org/10.24959/ophcj.19.174239","url":null,"abstract":"","PeriodicalId":34252,"journal":{"name":"Zhurnal organichnoyi ta farmatsevtichnoyi khimiyi","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69135315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信