Archives of Organ Transplantation最新文献

{"title":"Acute post-transplant oxalate nephropathy: A case report and review of the literature","authors":"Fantus Daniel, Gougeon Francois, Barama Azemi","doi":"10.17352/2640-7973.000022","DOIUrl":"https://doi.org/10.17352/2640-7973.000022","url":null,"abstract":"Calcium oxalate deposition in the kidney allograft remains an underappreciated cause of acute graft dysfunction. Diagnoses such as acute rejection, infection, hydronephrosis, and fluid collections are more immediately considered in the early post-transplant period. Risk factors include hyperoxaluria due to chronic fat malabsorption (post gastric bypass, inflammatory bowel disease), a diet rich in salt or animal protein, vitamin C ingestion, volume depletion, diabetes, and delayed graft function. We present the case of a patient who developed acute kidney injury secondary to oxalate nephropathy at 3 months post-transplant. Renal function improved with medical management, including volume repletion, calcium carbonate, and potassium citrate, without the need for hemodialysis. As more dialysis patients with morbid obesity requiring bariatric surgery, diabetes, and metabolic syndrome are being considered for renal transplantation, this entity merits more careful attention both prior to and after transplantation.","PeriodicalId":341678,"journal":{"name":"Archives of Organ Transplantation","volume":"22 S3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141384885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The efficacy of SARS-CoV-2 antibody response after two dose mRNA vaccination in kidney and heart transplant recipients using a multiplex bead-based assay: Evaluating the factors affecting vaccine response","authors":"Forte Steven J, Toepp Angela J, Bray Robert A, Baran David A, Gilgannon Lauren T, William J. Troy, Chen Shirui, Sadr Hooman, Gebel Howard M, Herre John M, McCune Thomas R","doi":"10.17352/2640-7973.000019","DOIUrl":"https://doi.org/10.17352/2640-7973.000019","url":null,"abstract":"Background: The extent that which immunosuppressive factors contribute to the antibody response to SARS-Cov-2 vaccination in solid organ transplant patients is being better understood. This study examined antibody formation against the spike SARS-CoV-2 protein (SA) when full vaccinations were up to 2 doses and boosters were not recommended. Immunosuppressive factors that affected the vaccine responsiveness in a cohort of 100 kidney and 50 heart transplant patients were evaluated. This study utilized a novel assay to detect antibodies against 4 different domains of the spike protein and the nucleocapsid protein (NC) of the SARS-CoV-2 virus on a multiplex, bead-based platform. Positive SARS-COV-2 antibodies (SA) response required identification of the receptor-binding domain and one of the three other spike protein domains. Prior SARS-CoV-2 infection could be determined by the presence of positive NC. Results: 150 patients were enrolled in the study (100 kidneys; 50 heart recipients). This study was performed when the Center for Disease Control and Prevention (CDC) recommended only two doses of Pfizer/BioNTech [BNT162b2] and Moderna [mRNA-1273 SARS-CoV-2] vaccine or 1 dose of Johnson & Johnson/Janssen [Ad26.COV2.S] vaccines for full SARS-CoV-2 vaccination in transplant recipients. Patients that reported a positive COVID-19 swab or had positive NC were excluded from the review because the prior infection may impact vaccine response (n = 134). Conclusions: SA were identified in 48/134 patients (36%); 25/46 heart (54%) and 23/88 kidney transplant patients (26%) (P = 0.0012). For the patients on prednisone therapy 25/93 responded with SA (27%) while for patients not on prednisone therapy, 23/41 responded with SA (56%) (P = 0.0012). The dose of steroids (5mg a day or greater) at the time of vaccination did not adversely affect vaccine efficacy (p = 0.054). Of the patients using antimetabolite therapy, 36/113 responded with SA (32%) while 12/21 patients not on antimetabolites responded with SA (57%) (P = .027). Time since transplant was not found to affect the rate of SA production when populations were separated by type of organ transplanted. T-cell depletion induction method, calcineurin inhibitor use, and type of SARS-CoV-2 vaccine were not found to be statistically significant.","PeriodicalId":341678,"journal":{"name":"Archives of Organ Transplantation","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128399212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of early relaparotomy in recipients of adult living donor liver transplantation","authors":"Ertugrul Gokhan, Tekin Atıf, Zenciroglu Mahmut","doi":"10.17352/2640-7973.000018","DOIUrl":"https://doi.org/10.17352/2640-7973.000018","url":null,"abstract":"","PeriodicalId":341678,"journal":{"name":"Archives of Organ Transplantation","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128122241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"BK virus in kidney transplantation: A single center experiences","authors":"G. Ertuğrul","doi":"10.17352/2640-7973.000013","DOIUrl":"https://doi.org/10.17352/2640-7973.000013","url":null,"abstract":"Background: BK virus is the most common infectious causes of nephropathy and graft loss after \u0000kidney transplantation. In our study, we investigated the factors that may affect positive BK virus in the \u0000blood in patients with kidney transplantation.","PeriodicalId":341678,"journal":{"name":"Archives of Organ Transplantation","volume":"118 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128119797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"To boldly go where no one has gone before in organ transplantation: Changes in mating behaviour and buffalo burger eating preferences of giant forest ants after successful brain transplant from American cockroaches","authors":"P. Griffin, C. Menor‐Salván, D. SamuelJackson, J. Chan, Jackson Sl","doi":"10.17352/2640-7973.000012","DOIUrl":"https://doi.org/10.17352/2640-7973.000012","url":null,"abstract":"The implications of ambimorphic archetypes in organ transplantation have been far-reaching and pervasive. After years of natural research into consistent hashing, we argue the simulation of public-private key pairs, which embodies the confi rmed principles of theory. Such a hypothesis might seem perverse but is derived from known results. Our focus in this paper is not on whether the well-known knowledge-based fact that humans breathe through their mouth or nose and the brain controls that critical function, so breathing would stop. The hardy vermin breathe through spiracles, or little holes in each body segment. Plus, the roach brain does not control this breathing and blood does not carry oxygen throughout the body. Overall, a new approach in succesful brain transplant have been developed.","PeriodicalId":341678,"journal":{"name":"Archives of Organ Transplantation","volume":"64 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123337102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Purpose of the measurement of intraoperative hepatic hemodynamics in liver transplant surgery","authors":"P. Lozano, Lorena Martín, M. Orue-Echebarria, J. M. Asencio, H. Sharma, J. A. Baena","doi":"10.17352/2640-7973.000011","DOIUrl":"https://doi.org/10.17352/2640-7973.000011","url":null,"abstract":"Liver graft function depends on different biological factors that are related to the donor, the recipient and the potential damage arising from the organ preservation technique. However, adequate hepatic artery flow and portal vein flow rates ensure a sufficient flow of oxygen and nutrients in order to ensure a suitable cellular graft function after the extreme metabolic decrease condition induced by hypothermia and the preservation solution. Liver inflow is a highly complex system due to its double irrigation system. These two systems are connected by the well-known “hepatic arterial buffer response” concept. This mechanism explains changes in hepatic arterial flow (HAF) as a compensation for changes in the portal vein flow (PVF), so that the hepatic artery adjusts total flow in relation to alterations in the portal blood flow. At the moment, the minimum HAF and PVF required for an adequate regeneration and functional recovery of the liver graft have not been yet established.","PeriodicalId":341678,"journal":{"name":"Archives of Organ Transplantation","volume":"53 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115653128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of high drain output after renal transplantation: Review of current evidence","authors":"Sajid Mohmad, Ajay K. Sharma, A. Halawa","doi":"10.17352/2640-7973.000010","DOIUrl":"https://doi.org/10.17352/2640-7973.000010","url":null,"abstract":"Surgical complications are not uncommon after renal transplantation. They should always be in the differential diagnosis of renal graft dysfunction. While ruling out or confirming a surgical cause of graft dysfunction, a sequential approach should be undertaken starting from clinical examination and moving on to more invasive investigations as the clinical picture becomes clearer. Biochemical assay of drain fluid is important. Causes of a collection around/near the graft include abscess, hematoma, urinoma and lymphocele. Treatment of each of them is different.","PeriodicalId":341678,"journal":{"name":"Archives of Organ Transplantation","volume":"102 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122618040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}