Recent Advances in Inflammation & Allergy Drug Discovery最新文献

{"title":"Unveiling Psoriasis: Delving into Pathogenesis, Treatment Breakthroughs,\u0000and Patent Trends","authors":"Azad Kumar Maurya, Dharmendra Jain","doi":"10.2174/0127722708307214240628042627","DOIUrl":"https://doi.org/10.2174/0127722708307214240628042627","url":null,"abstract":"\u0000\u0000Over the world, millions of individuals suffer from psoriasis, a chronic inflammatory\u0000skin disease. It is caused by a multifaceted mixture of environmental, immunological, and genetic\u0000factors. This review explores the many aspects of psoriasis, where the introduction gives a context\u0000background, emphasizing the prevalence and difficulties that people encounter with this dermatological ailment. Further, the pathogenesis complex systems involving immunological dysregulation, genetic susceptibility, and triggers are clarified, providing insights into the disease's fundamental mechanisms. Examining drugs shows how, over time, therapy modalities have evolved,\u0000moving from traditional topical treatments to the introduction of biologics and small molecules.\u0000The continuous efforts to control symptoms, reduce inflammation, and improve patient outcomes\u0000are highlighted in this section. Furthermore, a thorough review of patents reveals the creative advancements made in the sector, highlighting encouraging advancements in treatment modalities\u0000and potential paths forward. This manuscript is a review article and is based on various research\u0000and review articles. We have summarized the salient features and findings from different articles\u0000and prepared this manuscript.\u0000Over the world, millions of individuals suffer from psoriasis, a chronic inflammatory\u0000skin disease. It is caused by a multifaceted mixture of environmental, immunological, and genetic\u0000factors. This review explores the many aspects of psoriasis, where the introduction gives a context\u0000background, emphasizing the prevalence and difficulties that people encounter with this dermatological ailment. Further, the pathogenesis complex systems involving immunological dysregulation, genetic susceptibility, and triggers are clarified, providing insights into the disease's fundamental mechanisms. Examining drugs shows how, over time, therapy modalities have evolved,\u0000moving from traditional topical treatments to the introduction of biologics and small molecules.\u0000The continuous efforts to control symptoms, reduce inflammation, and improve patient outcomes\u0000are highlighted in this section. Furthermore, a thorough review of patents reveals the creative advancements made in the sector, highlighting encouraging advancements in treatment modalities\u0000and potential paths forward. This manuscript is a review article and is based on various research\u0000and review articles. We have summarized the salient features and findings from different articles\u0000and prepared this manuscript.\u0000","PeriodicalId":336476,"journal":{"name":"Recent Advances in Inflammation & Allergy Drug Discovery","volume":"19 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141661189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In silico Analysis of Berberine as a Potential Therapeutic Approach for\u0000Various Signalling Pathways Linked to Androgenetic Alopecia","authors":"Sagarika Majhi, Chaitanya Vinayak, Iti Chauhan, Madhu Verma, Sourabh Sharma","doi":"10.2174/0127722708307894240624105514","DOIUrl":"https://doi.org/10.2174/0127722708307894240624105514","url":null,"abstract":"\u0000\u0000Alopecia is defined by a loss of hair density and is often considered a\u0000symptom of multiple illnesses, such as infection and inflammation.\u0000\u0000\u0000\u0000The molecular mechanisms underlying the hair-promoting effects include inhibition of\u00005α-reductase activity, reducing the binding affinity of Dihydrotestosterone (DHT) to androgen receptors,\u0000and decreasing/down-regulating TGF-β2 activity, which have a suggestive role in androgenetic\u0000alopecia. Finasteride and minoxidil are the approved non-surgical treatment alternatives\u0000for hair loss, but they cause side effects in patients. Therefore, bioactive phytoconstituents with\u0000multiple targets can be used to find novel, secure, and efficacious hair-promoting medicinal products.\u0000\u0000\u0000\u0000This study has carried out the in silico evaluation of berberine using various software.\u0000To find possible interactions between the 5α-reductase enzyme and Transforming Growth Factor--\u0000beta 2 (TGF-β2), a critical protein involved in the human hair development cycle, computer-aided\u0000drug discovery was employed.\u0000\u0000\u0000\u0000According to in silico studies, berberine has been found to bind well to the 4K7a and\u00006M2N binding sites. The drug has been found to adhere to Lipinski's rule of five, and its pharmacokinetic\u0000characteristics were noteworthy. Drug-likeness and Absorption, Distribution,\u0000Metabolism, Excretion, and Toxicity (ADMET) properties showed appreciable results. Furthermore,\u0000berberine showed docking scores of -8.4 (5α-reductase) and -7.1 (TGF-β2), which were significantly\u0000better than minoxidil (-4.8, -3.2). In general, the drug exhibited improved binding interactions,\u0000and the possible toxicity investigations provided very little basis for risk prediction.\u0000\u0000\u0000\u0000The current protocol has offered experimental support for berberine's possible therapeutic\u0000use in reducing male pattern baldness. Therefore, it can be a possible target for the therapy\u0000of androgenetic alopecia through the regulation of TGF-β2 and 5α-reductase activity.\u0000","PeriodicalId":336476,"journal":{"name":"Recent Advances in Inflammation & Allergy Drug Discovery","volume":" 26","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141675077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Multi-trace Elements Supplementation on Biochemical Markers\u0000and Postoperative Outcome in Patients Undergoing Elective Cardiac Surgery","authors":"Mehran Amirizadeh, G. Eslami, Negar Shafaei-Bajestani, A. Soleimani, Solomon Habtemariam, Javad Hashemi, A. Sahebnasagh","doi":"10.2174/0127722708282330240522100230","DOIUrl":"https://doi.org/10.2174/0127722708282330240522100230","url":null,"abstract":"\u0000\u0000Coronary Artery Bypass Graft (CABG) surgery is employed to increase\u0000the lifespan of patients with Coronary Artery Disease (CAD). The low serum levels of essential elements\u0000have a negative effect on patients undergoing CABG.\u0000\u0000\u0000\u0000This clinical trial aimed to investigate the effect of trace elements supplements on postoperative\u0000outcomes after coronary artery bypass graft.\u0000\u0000\u0000\u0000Two hundred patients underwent on-pump CABG to randomly receive either\u0000Addamel©, which contains essential trace elements, or isotonic saline for 3 days. We measured\u0000postoperative plasma Zn, Se, Cu, Mn, Se, and Fe concentrations, and the levels of highly sensitive\u0000C-reactive Protein (hs-CRP) on days 0, 1, and 2. Duration of hospital and Intensive Care Unit\u0000(ICU) stay, 30-day mortality, and the incidence of Arterial Fibrillation (AF) have been evaluated\u0000as secondary outcomes.\u0000\u0000\u0000\u0000In the supplemented group, the plasma levels of Cu and Mn increased by day 3, and plasma\u0000hs-CRP increased by day 1 in both groups, but it decreased in patients who received trace elements\u0000supplementation on day 2. The Addamel group had a lower mortality rate, though the difference\u0000did not reach a significant level. There was a significant negative correlation observed between\u0000plasma Zn level and 30-day mortality, along with another significant negative link between\u0000plasma CRP level before operation and Sepsis-related Organ Failure Assessment (SOFA) score.\u0000Other measured parameters were similar between the intervention and placebo groups.\u0000\u0000\u0000\u0000The patients undergoing CABG appeared to benefit from trace element supplementation.\u0000A brief period of Addamel administration following CABG could prevent a decrease in the\u0000serum concentration of trace elements and reduce the circulating plasma CRP\u0000","PeriodicalId":336476,"journal":{"name":"Recent Advances in Inflammation & Allergy Drug Discovery","volume":"122 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141376695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}