International Journal of Molecular & Immuno Oncology最新文献

筛选

英文中文

Role of molecular diagnostics in determination of tissue of origin in Cancer of Unknown Primary (CUP) 分子诊断在未知原发癌(CUP)组织起源确定中的作用

International Journal of Molecular & Immuno Oncology Pub Date : 2019-05-20 DOI: 10.25259/ijmio-4-050

A. Verma, C. Goswami, V. Maniar

{"title":"Role of molecular diagnostics in determination of tissue of origin in Cancer of Unknown Primary (CUP)","authors":"A. Verma, C. Goswami, V. Maniar","doi":"10.25259/ijmio-4-050","DOIUrl":"https://doi.org/10.25259/ijmio-4-050","url":null,"abstract":"Cancer of unknown primary (CUP) is a condition seen in around 2–10% of patients with malignancy where the standard diagnostic workup fails to identify a specific tissue from which the tumor has arisen. As the survival of these patients is short, around 6–10 months, it becomes important to adopt newer technologies which aid in identifying the type of primary tumor so that the treatment can be guided based on the cancer type. Commonly used immunohistochemistry (IHC) panels may sometimes fail in providing a diagnosis as the CUP tissues contain usually either undifferentiated or dedifferentiate cells. Molecular cancer-classifier assay (MCCA) is an emerging diagnostic modality which is based on either gene expression profiling of the tumors or identification of epigenetic pattern of the tissues to make a probable diagnosis of the tissue from which the primary tumor may have arisen. Studies have shown that when tailored site-specific treatment was administered based on the outcomes of the MCCAs; an improvement in survival of the patients was seen. Recent NCCN guidelines suggest that the MCCAs should be used judiciously and on a case-to-case basis. The 2018 consensus statement from the Spanish Society of Pathology and the Spanish Society of Medical Oncology recognizes that the MCCAs are helpful when used to complement IHC, allowing for more accurate diagnosis of the primary site of tumor.","PeriodicalId":334889,"journal":{"name":"International Journal of Molecular & Immuno Oncology","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124008701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immunotherapy in esophageal cancer – An update 食管癌的免疫治疗-最新进展

International Journal of Molecular & Immuno Oncology Pub Date : 2019-05-20 DOI: 10.25259/ijmio-4-034

B. Parekh, N. Ghadlyalpatil, E. V. Chandarana, S. Hingmire, G. Sumant, V. Agarwala, A. Tiwari, G. Bhattacharyya, P. Parikh

引用次数: 0

4th molecular oncology conference (MOSCON): Untangling the genetic code 第四届分子肿瘤学会议:解开遗传密码

International Journal of Molecular & Immuno Oncology Pub Date : 2019-05-20 DOI: 10.25259/ijmio-4-031

O. Singha, Randeep K. Singh, P. Parikh

引用次数: 0

International Journal of Molecular &amp; Immuno Oncology最新文献

International Journal of Molecular & Immuno Oncology最新文献