Multidisciplinary Approach for Colorectal Cancer最新文献

Introductory Chapter: Multidisciplinary Colorectal Cancer - First Steps to Encompass Various Strategies for Preventing and Treating Colorectal Cancer 导论章:多学科结直肠癌-第一步包括预防和治疗结直肠癌的各种策略

Multidisciplinary Approach for Colorectal Cancer Pub Date : 2019-12-18 DOI: 10.5772/intechopen.89977

Keun-Yeong Jeong

{"title":"Introductory Chapter: Multidisciplinary Colorectal Cancer - First Steps to Encompass Various Strategies for Preventing and Treating Colorectal Cancer","authors":"Keun-Yeong Jeong","doi":"10.5772/intechopen.89977","DOIUrl":"https://doi.org/10.5772/intechopen.89977","url":null,"abstract":"Over the past decades, significant progress has been made in clinical and preclinical sciences. It has been lucky to see the integration of multiple discovery disciplines in science and medicine to push the limits of diagnosis and treatment of disorders that can affect many diseases. However, cancer is an exceptional disease that is relatively intractable and despite the multiple discovery disciplines scholarly. Colorectal cancer (CRC) is the third most common cause of cancer-associated mortality worldwide. According to the data from the National Center for Health Statistics, about 135,000 people are estimated to undergo chemotherapy with CRC in the USA each year, and approximately 50,000 people succumb to the disease annually [1]. Additionally, estimation of the Global Cancer Control project indicated that nearly 2 million people worldwide were diagnosed every year [2]. Wellknown option targeting CRC treatment is currently suggested surgical resection preferentially, and if the tumor progression is in an advanced stage, it does require combination with chemotherapy and/or radiation therapy. There is no doubt that surgery, chemotherapy, and radiation therapy are the best choices for treating CRC, even therapeutic efficiency is improving. However, it is still insufficient to reach a convincing level except for the case of early detection; therefore the craving for better potential therapies is still ongoing.","PeriodicalId":334373,"journal":{"name":"Multidisciplinary Approach for Colorectal Cancer","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130850335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effectivity and Modulating Pathways for the Prevention of Colorectal Cancer: Diet, Body Fatness, Physical Activity, and Supplementation 预防结直肠癌的有效性和调节途径:饮食、体脂、体力活动和补充

Multidisciplinary Approach for Colorectal Cancer Pub Date : 2019-12-11 DOI: 10.5772/intechopen.84764

S. Kassier

{"title":"Effectivity and Modulating Pathways for the Prevention of Colorectal Cancer: Diet, Body Fatness, Physical Activity, and Supplementation","authors":"S. Kassier","doi":"10.5772/intechopen.84764","DOIUrl":"https://doi.org/10.5772/intechopen.84764","url":null,"abstract":"The global prevalence of colorectal cancer (CRC) is currently the highest in high-income countries. However, a rapid increase in prevalence is starting to emerge in many low-income and middle-income countries. This phenomenon is thought to be related to the adoption of a Western lifestyle, characterized by a lack of physical activity, the consumption of refined cereals, as well as highly processed foods. Other characteristics include a reduction in fruit and vegetable intake with a concomitant increase in the consumption of foods that are energy dense, but lacking in micronutrients. Coupled to the above dietary and lifestyle changes is the advent of an increased prevalence of body fatness and central obesity, as well as a dietary intake that lends itself to increasing the risk of developing CRC. As there are observed inconsistencies when appraising the effectivity of dietary and lifestyle-cancer relationships, this chapter will provide an overview of the current body of evidence regarding the role of diet and proxies for lifestyle in terms of their preventative or causative roles in the development of CRC. In addition, the strength of scientific evidence will be alluded to, as well as the modulating pathways responsible for CRC causation or protection.","PeriodicalId":334373,"journal":{"name":"Multidisciplinary Approach for Colorectal Cancer","volume":"45 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115741633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immunoscore and Microbiome in Colorectal Cancer: What’s New? 结直肠癌的免疫评分和微生物组:有什么新发现?

Multidisciplinary Approach for Colorectal Cancer Pub Date : 2019-11-27 DOI: 10.5772/intechopen.86605

F. Macedo, N. Bonito, A. Longatto-Filho, Sandra F. Martins

{"title":"Immunoscore and Microbiome in Colorectal Cancer: What’s New?","authors":"F. Macedo, N. Bonito, A. Longatto-Filho, Sandra F. Martins","doi":"10.5772/intechopen.86605","DOIUrl":"https://doi.org/10.5772/intechopen.86605","url":null,"abstract":"Colorectal cancer (CRC) is the third most commonly diagnosed malignancy and the fourth leading cause of cancer death in the world, accounting for about 1.4 million new cases and almost 700,000 deaths in 2012. The clinical outcome and the tumor progression are now considered the result of a balance between the invasiveness of the tumor and the immune response of the patient against the tumor. The immune system has the ability to control and shape cancer through a mechanism called immunoediting, which include elimination, equilibrium, and escape. The consensus Immunoscore is a scoring system that outlines the density of CD3+ and CD8+ T-cell effectors existent in the tumor and its invasive margin. The pre-existing intra-tumoral immunity could be enhanced and activated by immunotherapy. Immunoscore could be a good prognostic marker, by identifying patients at high risk of tumor recurrence and stratifying patients who could benefit from adjuvant therapies. Human surfaces and cavities are populated by numerous microbial communities, and they play an indispensable role in human health, as they interact with the immune system. The authors made a literature revision concerning the role of Immunoscore and microbiome in colorectal cancer.","PeriodicalId":334373,"journal":{"name":"Multidisciplinary Approach for Colorectal Cancer","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132143133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Genetic Perspective on Colorectal Cancer Progression 结直肠癌进展的遗传学观点

Multidisciplinary Approach for Colorectal Cancer Pub Date : 2019-04-11 DOI: 10.5772/INTECHOPEN.85894

Lenuce Ribeiro Aziz Ydy, Willian Ricardo Camarço-Silva, Wilson Vilela Medeiros-Filho

引用次数: 1

Further Therapeutic Options in Heavily Pretreated Colorectal Cancer Patients 结直肠癌重度预处理患者的进一步治疗选择

Multidisciplinary Approach for Colorectal Cancer Pub Date : 2019-03-20 DOI: 10.5772/INTECHOPEN.85027

A. Zygulska

引用次数: 0