Dengue Fever - a Resilient Threat in the Face of Innovation最新文献

New Tools for Dengue Diagnostics 登革热诊断新工具

Dengue Fever - a Resilient Threat in the Face of Innovation Pub Date : 2019-01-30 DOI: 10.5772/INTECHOPEN.81059

O. Parkash, P. Kumari, Vasu Deva, S. Lal, Javed AhmedUjjan, Syed Mehmood Qadir, F. M. Soomro, RaniFaryal, N. A. Kanhar

引用次数: 2

Dengue Fever: A General Perspective 登革热:一般观点

Dengue Fever - a Resilient Threat in the Face of Innovation Pub Date : 2019-01-30 DOI: 10.5772/INTECHOPEN.81277

M. Zahoor, A. Rasul, M. Zahoor, Iqra Sarfraz, Muhammad Zulhussnain, Rizwan Rasool, Humara NazMajeed, F. Jabeen, Kanwal Ranian

{"title":"Dengue Fever: A General Perspective","authors":"M. Zahoor, A. Rasul, M. Zahoor, Iqra Sarfraz, Muhammad Zulhussnain, Rizwan Rasool, Humara NazMajeed, F. Jabeen, Kanwal Ranian","doi":"10.5772/INTECHOPEN.81277","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.81277","url":null,"abstract":"Dengue Fever or commonly known as Dengue, a mosquito-borne arboviral infection has emerged as havoc around the globe. Annually, about 50 million infections are reported, resulting in 22,000 deaths and almost 2.5 billion people are reported living at risk. Dengue infection is caused by Dengue Virus (DENV), which is a member of genus Flavivirus and comprised of ten proteins; three proteins, capsid (C), membrane (M), and envelope (E), play structural role and seven are identified as non-structural that direct DENV replication. Four distinct serotypes: DENV-1, DENV-2, DENV-3 and DENV-4 are transmitted via Aedes mosquitoes. Clinically, Dengue patients can be categorized into three groups according to WHO 2009 revised classification. Typical symptoms of dengue include: extreme fatigue; sudden fever (from 3-7 days), headache, joint, muscle, and back pain; vomiting and diarrhea, appetite loss; skin rash along minor bleeding. Aedes aegypti is geographically distributed in tropical areas and breeds in artificially filled water containers i.e. drums, tyres, flower vases plastic food containers, tin cans, etc. Due to four viral serotypes and non-availability of the model animal for dengue, producing vaccines is a challenging task. Thus, Dengue can be managed using various vector control strategies through physical, chemical and biological means.","PeriodicalId":330741,"journal":{"name":"Dengue Fever - a Resilient Threat in the Face of Innovation","volume":"213 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133103302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

The Burden of Dengue Illness and Its Economics Costs in the Americas: A Review on the Most Affected Countries 美洲登革热疾病负担及其经济成本:对受影响最严重国家的回顾

Dengue Fever - a Resilient Threat in the Face of Innovation Pub Date : 2018-12-05 DOI: 10.5772/INTECHOPEN.79887

R. Rodríguez, Jorge A. Rueda-Gallardo, ManuelFelipe Avella-Niño

{"title":"The Burden of Dengue Illness and Its Economics Costs in the Americas: A Review on the Most Affected Countries","authors":"R. Rodríguez, Jorge A. Rueda-Gallardo, ManuelFelipe Avella-Niño","doi":"10.5772/INTECHOPEN.79887","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.79887","url":null,"abstract":"According to the Pan American Health Organization (PAHO) reports, the annual average number of dengue cases in the Americas has been 1,579,658 in the last 8 years (2010 – 2017), affecting the population ’ s welfare. The high level in dengue cases does not only have an impact from an epidemiological perspective but also from an economical perspective as the treatment cost that must be borne. The aim of this chapter is to review the situation as reported in the American countries with the highest number of cases, focusing on the burden of the disease (measured in DALYs and number of cases) and its total treatment cost, which includes direct (medical and non-medical) costs and indirect costs. We calcu- late the total treatment cost per DALY for the epidemic year (2015). The results show that Mexico has the highest cost per DALY (US$ 17,703) followed by Brazil (US$ 11,218), Colombia (US$ 4,540), and the Dominican Republic (US$ 1,157). Additionally, after adjusting for total health expenditure, we found all the countries exhibit a similar share of total treatment cost over health expenditure (0.16% in average).","PeriodicalId":330741,"journal":{"name":"Dengue Fever - a Resilient Threat in the Face of Innovation","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129744765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Laboratory Tests Used in the Diagnostic and Research of Dengue Virus: Present and Future 用于登革热病毒诊断和研究的实验室检测:现在和未来

Dengue Fever - a Resilient Threat in the Face of Innovation Pub Date : 2018-11-05 DOI: 10.5772/INTECHOPEN.80519

Juan Samuel Sulca Herencia

{"title":"Laboratory Tests Used in the Diagnostic and Research of Dengue Virus: Present and Future","authors":"Juan Samuel Sulca Herencia","doi":"10.5772/INTECHOPEN.80519","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.80519","url":null,"abstract":"Dengue is a significant public health problem. There are four dengue virus serotypes identified; however, its diagnosis is difficult due to the existence of many viruses, bac -teria, and parasites producing the same clinical presentation, being present in the same geographical area and even producing coinfections. Therefore, determining whether a person has, had, or is infected with dengue virus is of great importance. In order to do so, direct and indirect laboratory tests have been developed to identify the virus or part of its structure that generally detects the antibody response. These techniques are used for diagnosis, epidemiological studies, monitoring, assessment and production of vaccines and antivirals, etc. They range from the use of cell cultures, animal models, inoculation by insects, and serology tests to the use of detection molecular tests and quantification of genetic material that are described in this chapter herein, a brief explanation of this methodology, its strengths and weaknesses, and its application in the dengue research. molecular techniques, and others. tubes, 6–96 well culture plates, and oth ers are used in order to sustain the binding to cell cultures. A modified shell vial technique allows the recovery of a higher number of YFV, SLV, WNV, ILHV, GCV, OROV, MAYV and DENV isolations. This technique follows the same steps as a standard method, but after inoculating cells, the cultures are centrifuged to velocities between 1800 and 2200 rpm. This technique can also be used to isolate DENV coinfections. However, it seems not to have good results for VEE isolation [19–22].","PeriodicalId":330741,"journal":{"name":"Dengue Fever - a Resilient Threat in the Face of Innovation","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116041679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Challenges for the Introduction and Evaluation of the Impact of Innovative Aedes aegypti Control Strategies 创新埃及伊蚊控制策略引入及效果评价面临的挑战

Dengue Fever - a Resilient Threat in the Face of Innovation Pub Date : 2018-11-05 DOI: 10.5772/INTECHOPEN.79862

H. Gómez-Dantés, N. Pavía-Ruz, F. Correa-Morales, Abdiel Martín-Park, G. Vazquez-Prokopec, P. Manrique-Saide

引用次数: 0

Mathematical Model as a Tool for the Control of Vector-Borne Diseases: Wolbachia Example 作为媒介传播疾病控制工具的数学模型:沃尔巴克氏体例子

Dengue Fever - a Resilient Threat in the Face of Innovation Pub Date : 2018-11-05 DOI: 10.5772/INTECHOPEN.79754

M. Z. Ndii, E. D. Wiraningsih, N. Anggriani, Asep K. Supriatna

引用次数: 1

Urban Ecology and the Effectiveness of Aedes Control 城市生态与伊蚊控制效果

Dengue Fever - a Resilient Threat in the Face of Innovation Pub Date : 2018-11-05 DOI: 10.5772/INTECHOPEN.78688

Wladimir J Alonso, B. McCormick

{"title":"Urban Ecology and the Effectiveness of Aedes Control","authors":"Wladimir J Alonso, B. McCormick","doi":"10.5772/INTECHOPEN.78688","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.78688","url":null,"abstract":"Past initiatives to control Aedes mosquitoes were successful, in part because they implemented draconian top-down control programs. To achieve similar results now, explicit recognition of the complexity in urban ecologies in terms of land ownership, law enforcement and accessibility for control interventions are required. By combining these attributes, four classes of spaces, along with corresponding control strategies, are suggested to better target Aedes species population control efforts. On one end of the spectrum there are accessible and accountable spaces (e.g. backyards and closely managed public facilities), where interventions can rely predominantly on bottom-up strategies with the local population playing the principle role in the implementation of actions, but with government coordination. On the other end of the spectrum are inaccessible and unaccountable spaces, which require top-down and extensive approaches. By identifying these and the intermediate classes of space, government and private resources can be allocated in a more efficient customized manner. Based on this new framework, a set of actions is proposed that might be implemented in dengue and other Aedes -borne crises. The framework considers existing limitations and opportunities associated with modern societies – which are fundamentally different from those associated with the successful control of Aedes species in the past.","PeriodicalId":330741,"journal":{"name":"Dengue Fever - a Resilient Threat in the Face of Innovation","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123733026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Ecology of Aedes Mosquitoes, the Major Vectors of Arboviruses in Human Population 伊蚊是虫媒病毒在人群中的主要传播媒介

Dengue Fever - a Resilient Threat in the Face of Innovation Pub Date : 2018-11-05 DOI: 10.5772/INTECHOPEN.81439

E. Kweka, Vito Baraka, L. Mathias, B. Mwang’onde, Germana T. Baraka, Lucile J. Lyaruu, A. Mahande

{"title":"Ecology of Aedes Mosquitoes, the Major Vectors of Arboviruses in Human Population","authors":"E. Kweka, Vito Baraka, L. Mathias, B. Mwang’onde, Germana T. Baraka, Lucile J. Lyaruu, A. Mahande","doi":"10.5772/INTECHOPEN.81439","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.81439","url":null,"abstract":"Aedes aegypti (Stegomyia) has been human vectors for many human diseases globally. In recent years, dengue virus has been diagnosed in different regions such as Asia and Latin America vectored by Aedes spp. mosquitoes. Dengue cases have been reported again in the several parts of African and other continental hospital. The different types of breed - ing sites have been found to be abundant in both urban and rural areas. The abundance of adult Ae. aegypti and habitat productivity in different settings escalates the risk of dengue transmission if viruses are found in asymptomatic population. The insecticide resistance has been found to occur in the wild population of Aedes aegypti to insecticides commonly used for indoor residual spray and long-lasting insecticidal net treatments. The control of human vector population is still a challenge as the vector has a diurnal feeding and outdoor resting behavior. Environmental management is still the best practice to be adopted in many countries for Aedes aegypti control. The currently discovered dengue vaccine might be an immediate arsenal for the community immunization.","PeriodicalId":330741,"journal":{"name":"Dengue Fever - a Resilient Threat in the Face of Innovation","volume":"228 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132493681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 20

Current Status of Vaccines against Dengue Virus 登革热病毒疫苗的现状

Dengue Fever - a Resilient Threat in the Face of Innovation Pub Date : 2018-11-05 DOI: 10.5772/INTECHOPEN.80820

J. C. Castaño-Osorio, Alejandra María Giraldo-García, M. Giraldo

引用次数: 10