Anastasia Feliciana, Andre Stefanus, Felix Ev, P YosuaAnthony, I. Suryanti, A. Ghozali, S RitaCempaka, F. Indrawati
{"title":"Effect of Phyllanthus niruri Extract on Low Density Lipoprotein of Dyslipidemic White Rats (Rattus norvegicus)","authors":"Anastasia Feliciana, Andre Stefanus, Felix Ev, P YosuaAnthony, I. Suryanti, A. Ghozali, S RitaCempaka, F. Indrawati","doi":"10.36648/2472-0151.5.2.100044","DOIUrl":"https://doi.org/10.36648/2472-0151.5.2.100044","url":null,"abstract":"Background: Dyslipidemia is a lipid metabolism disorder characterized by elevated levels of total cholesterol, Low Density Lipoprotein (LDL) and triglycerides and a decrease in high-density lipoprotein (HDL). Meniran contains tannins, saponins, alkaloids, rutin and quercetin, which have hypolipidemia effect. \u0000Objective: This study aimed to observe the effect of meniran extract on the Low Density Lipoprotein (LDL) in Wistar rats, compared with simvastatin. \u0000Methods: Thirty-five Wistar rats (Rattus novergicus) were divided into five groups, then all were induced with American Diet 2 (AD2) high fat modification diet for 60 days, except the control group I. Then during the next 60 days, groups I and II were not given any treatment, group III was given simvastatin 0.8 mg/200 g body weight (BW)/ day, group IV was given meniran extract 50 mg/200 g BW/day and group V was given meniran extract 100 mg/200 g BW/day. \u0000Results: Meniran therapy 50 mg/200 g BW/day was better in lowering LDL level than meniran dose 100 mg/200 g BW/day. Meniran therapy, which was significantly (p<0.05) better than simvastatin, was meniran dose of 50 mg/200 g BW/day in lowering LDL. \u0000Conclusion: Meniran therapy 50 mg/200 g BW/day can lower LDL level significantly. In this dose meniran decreased LDL better than simvastatin.","PeriodicalId":327373,"journal":{"name":"Herbal Medicine: Open Access","volume":"48 11","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114060524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}